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Article: Shh and ROCK1 modulate the dynamic epithelial morphogenesis in circumvallate papilla development

TitleShh and ROCK1 modulate the dynamic epithelial morphogenesis in circumvallate papilla development
Authors
Issue Date2009
PublisherAcademic Press. The Journal's web site is located at http://www.elsevier.com/locate/ydbio
Citation
Developmental Biology, 2009, v. 325 n. 1, p. 273-280 How to Cite?
AbstractIn rodents, a circumvallate papilla (CVP) develops with dynamic changes in epithelial morphogenesis during early tongue development. Molecular and cellular studies of CVP development revealed that there would be two different mechanisms in the apex and the trench wall forming regions with specific expression patterns of Wnt11 and Shh. Molecular interactions were examined using in vitro organ culture with over-expression of Shh, important signalling molecules and various inhibitors revealed that there are two significant different mechanisms in CVP formation by Wnt11 and Shh expressions. Wnt, a well known key molecule to initiate taste papillae, would govern Rho activation and cytoskeleton formation in the apex epithelium of CVP. In contrast, Shh regulates the cell proliferation to differentiate taste buds and to invaginate the epithelium for development of von Ebner's gland (VEG). Based on these results, we suggest that these different molecular signalling cascades of Wnt11 and Shh would play crucial roles in specific morphogenesis and pattern formation of CVP during early mouse embryo development. © 2008 Elsevier Inc. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/169554
ISSN
2014 Impact Factor: 3.547
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorKim, JYen_US
dc.contributor.authorLee, MJen_US
dc.contributor.authorCho, KWen_US
dc.contributor.authorLee, JMen_US
dc.contributor.authorKim, YJen_US
dc.contributor.authorKim, JYen_US
dc.contributor.authorJung, HIen_US
dc.contributor.authorCho, JYen_US
dc.contributor.authorCho, SWen_US
dc.contributor.authorJung, HSen_US
dc.date.accessioned2012-10-25T04:52:49Z-
dc.date.available2012-10-25T04:52:49Z-
dc.date.issued2009en_US
dc.identifier.citationDevelopmental Biology, 2009, v. 325 n. 1, p. 273-280en_US
dc.identifier.issn0012-1606en_US
dc.identifier.urihttp://hdl.handle.net/10722/169554-
dc.description.abstractIn rodents, a circumvallate papilla (CVP) develops with dynamic changes in epithelial morphogenesis during early tongue development. Molecular and cellular studies of CVP development revealed that there would be two different mechanisms in the apex and the trench wall forming regions with specific expression patterns of Wnt11 and Shh. Molecular interactions were examined using in vitro organ culture with over-expression of Shh, important signalling molecules and various inhibitors revealed that there are two significant different mechanisms in CVP formation by Wnt11 and Shh expressions. Wnt, a well known key molecule to initiate taste papillae, would govern Rho activation and cytoskeleton formation in the apex epithelium of CVP. In contrast, Shh regulates the cell proliferation to differentiate taste buds and to invaginate the epithelium for development of von Ebner's gland (VEG). Based on these results, we suggest that these different molecular signalling cascades of Wnt11 and Shh would play crucial roles in specific morphogenesis and pattern formation of CVP during early mouse embryo development. © 2008 Elsevier Inc. All rights reserved.en_US
dc.languageengen_US
dc.publisherAcademic Press. The Journal's web site is located at http://www.elsevier.com/locate/ydbioen_US
dc.relation.ispartofDevelopmental Biologyen_US
dc.subject.meshAmides - Pharmacologyen_US
dc.subject.meshAnimalsen_US
dc.subject.meshCell Movement - Drug Effectsen_US
dc.subject.meshEpithelium - Drug Effects - Embryology - Enzymology - Metabolismen_US
dc.subject.meshGene Expression Regulation, Developmental - Drug Effectsen_US
dc.subject.meshHedgehog Proteins - Metabolismen_US
dc.subject.meshMiceen_US
dc.subject.meshMice, Inbred Icren_US
dc.subject.meshModels, Biologicalen_US
dc.subject.meshMorphogenesis - Drug Effectsen_US
dc.subject.meshOrgan Culture Techniquesen_US
dc.subject.meshPyridines - Pharmacologyen_US
dc.subject.meshTongue - Cytology - Embryology - Enzymologyen_US
dc.subject.meshRho-Associated Kinases - Antagonists & Inhibitors - Metabolismen_US
dc.titleShh and ROCK1 modulate the dynamic epithelial morphogenesis in circumvallate papilla developmenten_US
dc.typeArticleen_US
dc.identifier.emailJung, HS: hsjung@yuhs.acen_US
dc.identifier.authorityJung, HS=rp01683en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/j.ydbio.2008.10.034en_US
dc.identifier.pmid19014928en_US
dc.identifier.scopuseid_2-s2.0-58049196771en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-58049196771&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume325en_US
dc.identifier.issue1en_US
dc.identifier.spage273en_US
dc.identifier.epage280en_US
dc.identifier.isiWOS:000262459600026-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridKim, JY=7601361822en_US
dc.identifier.scopusauthoridLee, MJ=35264472100en_US
dc.identifier.scopusauthoridCho, KW=7403956665en_US
dc.identifier.scopusauthoridLee, JM=25622544900en_US
dc.identifier.scopusauthoridKim, YJ=16833275700en_US
dc.identifier.scopusauthoridKim, JY=7601381285en_US
dc.identifier.scopusauthoridJung, HI=25929998200en_US
dc.identifier.scopusauthoridCho, JY=7403534464en_US
dc.identifier.scopusauthoridCho, SW=32967447200en_US
dc.identifier.scopusauthoridJung, HS=7403030195en_US

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