Article: Shh and ROCK1 modulate the dynamic epithelial morphogenesis in circumvallate papilla development

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TitleShh and ROCK1 modulate the dynamic epithelial morphogenesis in circumvallate papilla development
AuthorsKim, JY1
Lee, MJ2
Cho, KW2
Lee, JM2
Kim, YJ2
Kim, JY2
Jung, HI1
Cho, JY1
Cho, SW2
Jung, HS2
Issue Date2009
PublisherAcademic Press. The Journal's web site is located at http://www.elsevier.com/locate/ydbio
CitationDevelopmental Biology, 2009, v. 325 n. 1, p. 273-280 [How to Cite?]
DOI: http://dx.doi.org/10.1016/j.ydbio.2008.10.034
AbstractIn rodents, a circumvallate papilla (CVP) develops with dynamic changes in epithelial morphogenesis during early tongue development. Molecular and cellular studies of CVP development revealed that there would be two different mechanisms in the apex and the trench wall forming regions with specific expression patterns of Wnt11 and Shh. Molecular interactions were examined using in vitro organ culture with over-expression of Shh, important signalling molecules and various inhibitors revealed that there are two significant different mechanisms in CVP formation by Wnt11 and Shh expressions. Wnt, a well known key molecule to initiate taste papillae, would govern Rho activation and cytoskeleton formation in the apex epithelium of CVP. In contrast, Shh regulates the cell proliferation to differentiate taste buds and to invaginate the epithelium for development of von Ebner's gland (VEG). Based on these results, we suggest that these different molecular signalling cascades of Wnt11 and Shh would play crucial roles in specific morphogenesis and pattern formation of CVP during early mouse embryo development. © 2008 Elsevier Inc. All rights reserved.
ISSN0012-1606
2011 Impact Factor: 4.069
2011 SCImago Journal Rankings: 0.877
DOIhttp://dx.doi.org/10.1016/j.ydbio.2008.10.034
ReferencesReferences in Scopus
DC Field
Value
dc.contributor.authorKim, JY
dc.contributor.authorLee, MJ
dc.contributor.authorCho, KW
dc.contributor.authorLee, JM
dc.contributor.authorKim, YJ
dc.contributor.authorKim, JY
dc.contributor.authorJung, HI
dc.contributor.authorCho, JY
dc.contributor.authorCho, SW
dc.contributor.authorJung, HS
dc.date.accessioned2012-10-25T04:52:49Z
dc.date.available2012-10-25T04:52:49Z
dc.date.issued2009
dc.description.abstractIn rodents, a circumvallate papilla (CVP) develops with dynamic changes in epithelial morphogenesis during early tongue development. Molecular and cellular studies of CVP development revealed that there would be two different mechanisms in the apex and the trench wall forming regions with specific expression patterns of Wnt11 and Shh. Molecular interactions were examined using in vitro organ culture with over-expression of Shh, important signalling molecules and various inhibitors revealed that there are two significant different mechanisms in CVP formation by Wnt11 and Shh expressions. Wnt, a well known key molecule to initiate taste papillae, would govern Rho activation and cytoskeleton formation in the apex epithelium of CVP. In contrast, Shh regulates the cell proliferation to differentiate taste buds and to invaginate the epithelium for development of von Ebner's gland (VEG). Based on these results, we suggest that these different molecular signalling cascades of Wnt11 and Shh would play crucial roles in specific morphogenesis and pattern formation of CVP during early mouse embryo development. © 2008 Elsevier Inc. All rights reserved.
dc.description.natureLink_to_subscribed_fulltext
dc.identifier.citationDevelopmental Biology, 2009, v. 325 n. 1, p. 273-280 [How to Cite?]
DOI: http://dx.doi.org/10.1016/j.ydbio.2008.10.034
dc.identifier.doihttp://dx.doi.org/10.1016/j.ydbio.2008.10.034
dc.identifier.epage280
dc.identifier.issn0012-1606
2011 Impact Factor: 4.069
2011 SCImago Journal Rankings: 0.877
dc.identifier.issue1
dc.identifier.pmid19014928
dc.identifier.scopuseid_2-s2.0-58049196771
dc.identifier.spage273
dc.identifier.urihttp://hdl.handle.net/10722/169554
dc.identifier.volume325
dc.languageeng
dc.publisherAcademic Press. The Journal's web site is located at http://www.elsevier.com/locate/ydbio
dc.publisher.placeUnited States
dc.relation.ispartofDevelopmental Biology
dc.relation.referencesReferences in Scopus
dc.subject.meshAmides - Pharmacology
dc.subject.meshAnimals
dc.subject.meshCell Movement - Drug Effects
dc.subject.meshEpithelium - Drug Effects - Embryology - Enzymology - Metabolism
dc.subject.meshGene Expression Regulation, Developmental - Drug Effects
dc.subject.meshHedgehog Proteins - Metabolism
dc.subject.meshMice
dc.subject.meshMice, Inbred Icr
dc.subject.meshModels, Biological
dc.subject.meshMorphogenesis - Drug Effects
dc.subject.meshOrgan Culture Techniques
dc.subject.meshPyridines - Pharmacology
dc.subject.meshTongue - Cytology - Embryology - Enzymology
dc.subject.meshRho-Associated Kinases - Antagonists & Inhibitors - Metabolism
dc.titleShh and ROCK1 modulate the dynamic epithelial morphogenesis in circumvallate papilla development
dc.typeArticle
Author Affiliations
  1. School of Medicine
  2. Research Center for Orofacial Hard Tissue Regeneration