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Article: Shh and ROCK1 modulate the dynamic epithelial morphogenesis in circumvallate papilla development
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TitleShh and ROCK1 modulate the dynamic epithelial morphogenesis in circumvallate papilla development
 
AuthorsKim, JY1
Lee, MJ2
Cho, KW2
Lee, JM2
Kim, YJ2
Kim, JY2
Jung, HI1
Cho, JY1
Cho, SW2
Jung, HS2
 
Issue Date2009
 
PublisherAcademic Press. The Journal's web site is located at http://www.elsevier.com/locate/ydbio
 
CitationDevelopmental Biology, 2009, v. 325 n. 1, p. 273-280 [How to Cite?]
DOI: http://dx.doi.org/10.1016/j.ydbio.2008.10.034
 
AbstractIn rodents, a circumvallate papilla (CVP) develops with dynamic changes in epithelial morphogenesis during early tongue development. Molecular and cellular studies of CVP development revealed that there would be two different mechanisms in the apex and the trench wall forming regions with specific expression patterns of Wnt11 and Shh. Molecular interactions were examined using in vitro organ culture with over-expression of Shh, important signalling molecules and various inhibitors revealed that there are two significant different mechanisms in CVP formation by Wnt11 and Shh expressions. Wnt, a well known key molecule to initiate taste papillae, would govern Rho activation and cytoskeleton formation in the apex epithelium of CVP. In contrast, Shh regulates the cell proliferation to differentiate taste buds and to invaginate the epithelium for development of von Ebner's gland (VEG). Based on these results, we suggest that these different molecular signalling cascades of Wnt11 and Shh would play crucial roles in specific morphogenesis and pattern formation of CVP during early mouse embryo development. © 2008 Elsevier Inc. All rights reserved.
 
ISSN0012-1606
2012 Impact Factor: 3.868
2012 SCImago Journal Rankings: 2.329
 
DOIhttp://dx.doi.org/10.1016/j.ydbio.2008.10.034
 
ReferencesReferences in Scopus
 
DC FieldValue
dc.contributor.authorKim, JY
 
dc.contributor.authorLee, MJ
 
dc.contributor.authorCho, KW
 
dc.contributor.authorLee, JM
 
dc.contributor.authorKim, YJ
 
dc.contributor.authorKim, JY
 
dc.contributor.authorJung, HI
 
dc.contributor.authorCho, JY
 
dc.contributor.authorCho, SW
 
dc.contributor.authorJung, HS
 
dc.date.accessioned2012-10-25T04:52:49Z
 
dc.date.available2012-10-25T04:52:49Z
 
dc.date.issued2009
 
dc.description.abstractIn rodents, a circumvallate papilla (CVP) develops with dynamic changes in epithelial morphogenesis during early tongue development. Molecular and cellular studies of CVP development revealed that there would be two different mechanisms in the apex and the trench wall forming regions with specific expression patterns of Wnt11 and Shh. Molecular interactions were examined using in vitro organ culture with over-expression of Shh, important signalling molecules and various inhibitors revealed that there are two significant different mechanisms in CVP formation by Wnt11 and Shh expressions. Wnt, a well known key molecule to initiate taste papillae, would govern Rho activation and cytoskeleton formation in the apex epithelium of CVP. In contrast, Shh regulates the cell proliferation to differentiate taste buds and to invaginate the epithelium for development of von Ebner's gland (VEG). Based on these results, we suggest that these different molecular signalling cascades of Wnt11 and Shh would play crucial roles in specific morphogenesis and pattern formation of CVP during early mouse embryo development. © 2008 Elsevier Inc. All rights reserved.
 
dc.description.natureLink_to_subscribed_fulltext
 
dc.identifier.citationDevelopmental Biology, 2009, v. 325 n. 1, p. 273-280 [How to Cite?]
DOI: http://dx.doi.org/10.1016/j.ydbio.2008.10.034
 
dc.identifier.doihttp://dx.doi.org/10.1016/j.ydbio.2008.10.034
 
dc.identifier.epage280
 
dc.identifier.issn0012-1606
2012 Impact Factor: 3.868
2012 SCImago Journal Rankings: 2.329
 
dc.identifier.issue1
 
dc.identifier.pmid19014928
 
dc.identifier.scopuseid_2-s2.0-58049196771
 
dc.identifier.spage273
 
dc.identifier.urihttp://hdl.handle.net/10722/169554
 
dc.identifier.volume325
 
dc.languageeng
 
dc.publisherAcademic Press. The Journal's web site is located at http://www.elsevier.com/locate/ydbio
 
dc.publisher.placeUnited States
 
dc.relation.ispartofDevelopmental Biology
 
dc.relation.referencesReferences in Scopus
 
dc.subject.meshAmides - Pharmacology
 
dc.subject.meshAnimals
 
dc.subject.meshCell Movement - Drug Effects
 
dc.subject.meshEpithelium - Drug Effects - Embryology - Enzymology - Metabolism
 
dc.subject.meshGene Expression Regulation, Developmental - Drug Effects
 
dc.subject.meshHedgehog Proteins - Metabolism
 
dc.subject.meshMice
 
dc.subject.meshMice, Inbred Icr
 
dc.subject.meshModels, Biological
 
dc.subject.meshMorphogenesis - Drug Effects
 
dc.subject.meshOrgan Culture Techniques
 
dc.subject.meshPyridines - Pharmacology
 
dc.subject.meshTongue - Cytology - Embryology - Enzymology
 
dc.subject.meshRho-Associated Kinases - Antagonists & Inhibitors - Metabolism
 
dc.titleShh and ROCK1 modulate the dynamic epithelial morphogenesis in circumvallate papilla development
 
dc.typeArticle
 
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Author Affiliations
  1. School of Medicine
  2. Research Center for Orofacial Hard Tissue Regeneration