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Article: Growth effects of botulinum toxin type A injected into masseter muscle on a developing rat mandible

TitleGrowth effects of botulinum toxin type A injected into masseter muscle on a developing rat mandible
Authors
Issue Date2008
PublisherWiley-Blackwell Publishing, Inc.. The Journal's web site is located at http://www.wiley.com/bw/journal.asp?ref=1354-523X&site=1
Citation
Oral Diseases, 2008, v. 14 n. 7, p. 626-632 How to Cite?
Abstract
Objectives: Botulinum toxin type A (BTX-A) reduces the muscular contractions by temporarily inhibiting the release of acetylcholine at the neuromuscular junction. The purpose of this study was to investigate the effects of the BTX-A injected into the masseter muscle of a developing rat mandible. Materials and methods: Four-week-old male (no. 80) Sprague-Dawley rats were divided into four groups: control group, saline group, BTX-A group and baseline control group. Rats of baseline group were sacrificed at 0 day to provide baseline values of the mandibular measurements. The masseter muscle of rats in the saline and the BTX-A group were administered with saline and BTX-A solutions respectively. Experimental animals were sacrificed after 4 weeks. Results: The BTX-A group demonstrated smaller mandibular dimension compared with the other groups (P < 0.05). Their condylar cartilages showed increased apoptosis at the proliferation stage of the reserve zone and masseter muscle fibers demonstrated atrophic changes. Conclusions: The result demonstrated BTX-A influence on inhibitory action of the developing mandible because of apoptosis at the proliferation stage of the reserve zone of the condylar cartilage in developing rat mandible. © 2008 The Authors.
Persistent Identifierhttp://hdl.handle.net/10722/169550
ISSN
2013 Impact Factor: 2.404
ISI Accession Number ID
References

 

Author Affiliations
  1. SungKyunKwan University, School of Medicine
  2. Yonsei University
DC FieldValueLanguage
dc.contributor.authorKim, JYen_US
dc.contributor.authorKim, STen_US
dc.contributor.authorCho, SWen_US
dc.contributor.authorJung, HSen_US
dc.contributor.authorPark, KTen_US
dc.contributor.authorSon, HKen_US
dc.date.accessioned2012-10-25T04:52:47Z-
dc.date.available2012-10-25T04:52:47Z-
dc.date.issued2008en_US
dc.identifier.citationOral Diseases, 2008, v. 14 n. 7, p. 626-632en_US
dc.identifier.issn1354-523Xen_US
dc.identifier.urihttp://hdl.handle.net/10722/169550-
dc.description.abstractObjectives: Botulinum toxin type A (BTX-A) reduces the muscular contractions by temporarily inhibiting the release of acetylcholine at the neuromuscular junction. The purpose of this study was to investigate the effects of the BTX-A injected into the masseter muscle of a developing rat mandible. Materials and methods: Four-week-old male (no. 80) Sprague-Dawley rats were divided into four groups: control group, saline group, BTX-A group and baseline control group. Rats of baseline group were sacrificed at 0 day to provide baseline values of the mandibular measurements. The masseter muscle of rats in the saline and the BTX-A group were administered with saline and BTX-A solutions respectively. Experimental animals were sacrificed after 4 weeks. Results: The BTX-A group demonstrated smaller mandibular dimension compared with the other groups (P < 0.05). Their condylar cartilages showed increased apoptosis at the proliferation stage of the reserve zone and masseter muscle fibers demonstrated atrophic changes. Conclusions: The result demonstrated BTX-A influence on inhibitory action of the developing mandible because of apoptosis at the proliferation stage of the reserve zone of the condylar cartilage in developing rat mandible. © 2008 The Authors.en_US
dc.languageengen_US
dc.publisherWiley-Blackwell Publishing, Inc.. The Journal's web site is located at http://www.wiley.com/bw/journal.asp?ref=1354-523X&site=1en_US
dc.relation.ispartofOral Diseasesen_US
dc.subject.meshAnimalsen_US
dc.subject.meshApoptosisen_US
dc.subject.meshBotulinum Toxins, Type A - Administration & Dosage - Pharmacologyen_US
dc.subject.meshCartilage, Articular - Drug Effectsen_US
dc.subject.meshInjections, Intramuscularen_US
dc.subject.meshMaleen_US
dc.subject.meshMandible - Drug Effects - Growth & Developmenten_US
dc.subject.meshMandibular Condyle - Drug Effectsen_US
dc.subject.meshMasseter Muscle - Drug Effectsen_US
dc.subject.meshMaxillofacial Development - Drug Effectsen_US
dc.subject.meshRatsen_US
dc.subject.meshRats, Sprague-Dawleyen_US
dc.titleGrowth effects of botulinum toxin type A injected into masseter muscle on a developing rat mandibleen_US
dc.typeArticleen_US
dc.identifier.emailJung, HS: hsjung@yuhs.acen_US
dc.identifier.authorityJung, HS=rp01683en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1111/j.1601-0825.2007.01435.xen_US
dc.identifier.pmid18331419en_US
dc.identifier.scopuseid_2-s2.0-53149145069en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-53149145069&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume14en_US
dc.identifier.issue7en_US
dc.identifier.spage626en_US
dc.identifier.epage632en_US
dc.identifier.isiWOS:000259684700008-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridKim, JY=7601364064en_US
dc.identifier.scopusauthoridKim, ST=18437214500en_US
dc.identifier.scopusauthoridCho, SW=32967447200en_US
dc.identifier.scopusauthoridJung, HS=7403030195en_US
dc.identifier.scopusauthoridPark, KT=7408066901en_US
dc.identifier.scopusauthoridSon, HK=12769270800en_US
dc.identifier.citeulike3374120-

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