Article: Growth effects of botulinum toxin type A injected into masseter muscle on a developing rat mandible

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TitleGrowth effects of botulinum toxin type A injected into masseter muscle on a developing rat mandible
AuthorsKim, JY1
Kim, ST2
Cho, SW2
Jung, HS2
Park, KT1
Son, HK2
Issue Date2008
PublisherWiley-Blackwell Publishing, Inc.. The Journal's web site is located at http://www.wiley.com/bw/journal.asp?ref=1354-523X&site=1
CitationOral Diseases, 2008, v. 14 n. 7, p. 626-632 [How to Cite?]
DOI: http://dx.doi.org/10.1111/j.1601-0825.2007.01435.x
AbstractObjectives: Botulinum toxin type A (BTX-A) reduces the muscular contractions by temporarily inhibiting the release of acetylcholine at the neuromuscular junction. The purpose of this study was to investigate the effects of the BTX-A injected into the masseter muscle of a developing rat mandible. Materials and methods: Four-week-old male (no. 80) Sprague-Dawley rats were divided into four groups: control group, saline group, BTX-A group and baseline control group. Rats of baseline group were sacrificed at 0 day to provide baseline values of the mandibular measurements. The masseter muscle of rats in the saline and the BTX-A group were administered with saline and BTX-A solutions respectively. Experimental animals were sacrificed after 4 weeks. Results: The BTX-A group demonstrated smaller mandibular dimension compared with the other groups (P < 0.05). Their condylar cartilages showed increased apoptosis at the proliferation stage of the reserve zone and masseter muscle fibers demonstrated atrophic changes. Conclusions: The result demonstrated BTX-A influence on inhibitory action of the developing mandible because of apoptosis at the proliferation stage of the reserve zone of the condylar cartilage in developing rat mandible. © 2008 The Authors.
ISSN1354-523X
2011 Impact Factor: 2.495
2011 SCImago Journal Rankings: 0.168
DOIhttp://dx.doi.org/10.1111/j.1601-0825.2007.01435.x
ReferencesReferences in Scopus
DC Field
Value
dc.contributor.authorKim, JY
dc.contributor.authorKim, ST
dc.contributor.authorCho, SW
dc.contributor.authorJung, HS
dc.contributor.authorPark, KT
dc.contributor.authorSon, HK
dc.date.accessioned2012-10-25T04:52:47Z
dc.date.available2012-10-25T04:52:47Z
dc.date.issued2008
dc.description.abstractObjectives: Botulinum toxin type A (BTX-A) reduces the muscular contractions by temporarily inhibiting the release of acetylcholine at the neuromuscular junction. The purpose of this study was to investigate the effects of the BTX-A injected into the masseter muscle of a developing rat mandible. Materials and methods: Four-week-old male (no. 80) Sprague-Dawley rats were divided into four groups: control group, saline group, BTX-A group and baseline control group. Rats of baseline group were sacrificed at 0 day to provide baseline values of the mandibular measurements. The masseter muscle of rats in the saline and the BTX-A group were administered with saline and BTX-A solutions respectively. Experimental animals were sacrificed after 4 weeks. Results: The BTX-A group demonstrated smaller mandibular dimension compared with the other groups (P < 0.05). Their condylar cartilages showed increased apoptosis at the proliferation stage of the reserve zone and masseter muscle fibers demonstrated atrophic changes. Conclusions: The result demonstrated BTX-A influence on inhibitory action of the developing mandible because of apoptosis at the proliferation stage of the reserve zone of the condylar cartilage in developing rat mandible. © 2008 The Authors.
dc.description.natureLink_to_subscribed_fulltext
dc.identifier.citationOral Diseases, 2008, v. 14 n. 7, p. 626-632 [How to Cite?]
DOI: http://dx.doi.org/10.1111/j.1601-0825.2007.01435.x
dc.identifier.citeulike3374120
dc.identifier.doihttp://dx.doi.org/10.1111/j.1601-0825.2007.01435.x
dc.identifier.epage632
dc.identifier.issn1354-523X
2011 Impact Factor: 2.495
2011 SCImago Journal Rankings: 0.168
dc.identifier.issue7
dc.identifier.pmid18331419
dc.identifier.scopuseid_2-s2.0-53149145069
dc.identifier.spage626
dc.identifier.urihttp://hdl.handle.net/10722/169550
dc.identifier.volume14
dc.languageeng
dc.publisherWiley-Blackwell Publishing, Inc.. The Journal's web site is located at http://www.wiley.com/bw/journal.asp?ref=1354-523X&site=1
dc.publisher.placeUnited States
dc.relation.ispartofOral Diseases
dc.relation.referencesReferences in Scopus
dc.subject.meshAnimals
dc.subject.meshApoptosis
dc.subject.meshBotulinum Toxins, Type A - Administration & Dosage - Pharmacology
dc.subject.meshCartilage, Articular - Drug Effects
dc.subject.meshInjections, Intramuscular
dc.subject.meshMale
dc.subject.meshMandible - Drug Effects - Growth & Development
dc.subject.meshMandibular Condyle - Drug Effects
dc.subject.meshMasseter Muscle - Drug Effects
dc.subject.meshMaxillofacial Development - Drug Effects
dc.subject.meshRats
dc.subject.meshRats, Sprague-Dawley
dc.titleGrowth effects of botulinum toxin type A injected into masseter muscle on a developing rat mandible
dc.typeArticle
Author Affiliations
  1. SungKyunKwan University, School of Medicine
  2. Yonsei University