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- Publisher Website: 10.1111/j.1601-0825.2007.01435.x
- Scopus: eid_2-s2.0-53149145069
- PMID: 18331419
- WOS: WOS:000259684700008
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Article: Growth effects of botulinum toxin type A injected into masseter muscle on a developing rat mandible
Title | Growth effects of botulinum toxin type A injected into masseter muscle on a developing rat mandible |
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Authors | |
Keywords | Botulinum toxin type A Condylar cartilage Masseter muscle Rat mandible |
Issue Date | 2008 |
Publisher | Wiley-Blackwell Publishing, Inc.. The Journal's web site is located at http://www.wiley.com/bw/journal.asp?ref=1354-523X&site=1 |
Citation | Oral Diseases, 2008, v. 14 n. 7, p. 626-632 How to Cite? |
Abstract | Objectives: Botulinum toxin type A (BTX-A) reduces the muscular contractions by temporarily inhibiting the release of acetylcholine at the neuromuscular junction. The purpose of this study was to investigate the effects of the BTX-A injected into the masseter muscle of a developing rat mandible. Materials and methods: Four-week-old male (no. 80) Sprague-Dawley rats were divided into four groups: control group, saline group, BTX-A group and baseline control group. Rats of baseline group were sacrificed at 0 day to provide baseline values of the mandibular measurements. The masseter muscle of rats in the saline and the BTX-A group were administered with saline and BTX-A solutions respectively. Experimental animals were sacrificed after 4 weeks. Results: The BTX-A group demonstrated smaller mandibular dimension compared with the other groups (P < 0.05). Their condylar cartilages showed increased apoptosis at the proliferation stage of the reserve zone and masseter muscle fibers demonstrated atrophic changes. Conclusions: The result demonstrated BTX-A influence on inhibitory action of the developing mandible because of apoptosis at the proliferation stage of the reserve zone of the condylar cartilage in developing rat mandible. © 2008 The Authors. |
Persistent Identifier | http://hdl.handle.net/10722/169550 |
ISSN | 2023 Impact Factor: 2.9 2023 SCImago Journal Rankings: 0.895 |
ISI Accession Number ID | |
References |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, JY | en_US |
dc.contributor.author | Kim, ST | en_US |
dc.contributor.author | Cho, SW | en_US |
dc.contributor.author | Jung, HS | en_US |
dc.contributor.author | Park, KT | en_US |
dc.contributor.author | Son, HK | en_US |
dc.date.accessioned | 2012-10-25T04:52:47Z | - |
dc.date.available | 2012-10-25T04:52:47Z | - |
dc.date.issued | 2008 | en_US |
dc.identifier.citation | Oral Diseases, 2008, v. 14 n. 7, p. 626-632 | en_US |
dc.identifier.issn | 1354-523X | en_US |
dc.identifier.uri | http://hdl.handle.net/10722/169550 | - |
dc.description.abstract | Objectives: Botulinum toxin type A (BTX-A) reduces the muscular contractions by temporarily inhibiting the release of acetylcholine at the neuromuscular junction. The purpose of this study was to investigate the effects of the BTX-A injected into the masseter muscle of a developing rat mandible. Materials and methods: Four-week-old male (no. 80) Sprague-Dawley rats were divided into four groups: control group, saline group, BTX-A group and baseline control group. Rats of baseline group were sacrificed at 0 day to provide baseline values of the mandibular measurements. The masseter muscle of rats in the saline and the BTX-A group were administered with saline and BTX-A solutions respectively. Experimental animals were sacrificed after 4 weeks. Results: The BTX-A group demonstrated smaller mandibular dimension compared with the other groups (P < 0.05). Their condylar cartilages showed increased apoptosis at the proliferation stage of the reserve zone and masseter muscle fibers demonstrated atrophic changes. Conclusions: The result demonstrated BTX-A influence on inhibitory action of the developing mandible because of apoptosis at the proliferation stage of the reserve zone of the condylar cartilage in developing rat mandible. © 2008 The Authors. | en_US |
dc.language | eng | en_US |
dc.publisher | Wiley-Blackwell Publishing, Inc.. The Journal's web site is located at http://www.wiley.com/bw/journal.asp?ref=1354-523X&site=1 | en_US |
dc.relation.ispartof | Oral Diseases | en_US |
dc.subject | Botulinum toxin type A | - |
dc.subject | Condylar cartilage | - |
dc.subject | Masseter muscle | - |
dc.subject | Rat mandible | - |
dc.subject.mesh | Animals | en_US |
dc.subject.mesh | Apoptosis | en_US |
dc.subject.mesh | Botulinum Toxins, Type A - Administration & Dosage - Pharmacology | en_US |
dc.subject.mesh | Cartilage, Articular - Drug Effects | en_US |
dc.subject.mesh | Injections, Intramuscular | en_US |
dc.subject.mesh | Male | en_US |
dc.subject.mesh | Mandible - Drug Effects - Growth & Development | en_US |
dc.subject.mesh | Mandibular Condyle - Drug Effects | en_US |
dc.subject.mesh | Masseter Muscle - Drug Effects | en_US |
dc.subject.mesh | Maxillofacial Development - Drug Effects | en_US |
dc.subject.mesh | Rats | en_US |
dc.subject.mesh | Rats, Sprague-Dawley | en_US |
dc.title | Growth effects of botulinum toxin type A injected into masseter muscle on a developing rat mandible | en_US |
dc.type | Article | en_US |
dc.identifier.email | Jung, HS: hsjung@yuhs.ac | en_US |
dc.identifier.authority | Jung, HS=rp01683 | en_US |
dc.description.nature | link_to_subscribed_fulltext | en_US |
dc.identifier.doi | 10.1111/j.1601-0825.2007.01435.x | en_US |
dc.identifier.pmid | 18331419 | en_US |
dc.identifier.scopus | eid_2-s2.0-53149145069 | en_US |
dc.relation.references | http://www.scopus.com/mlt/select.url?eid=2-s2.0-53149145069&selection=ref&src=s&origin=recordpage | en_US |
dc.identifier.volume | 14 | en_US |
dc.identifier.issue | 7 | en_US |
dc.identifier.spage | 626 | en_US |
dc.identifier.epage | 632 | en_US |
dc.identifier.isi | WOS:000259684700008 | - |
dc.publisher.place | United States | en_US |
dc.identifier.scopusauthorid | Kim, JY=7601364064 | en_US |
dc.identifier.scopusauthorid | Kim, ST=18437214500 | en_US |
dc.identifier.scopusauthorid | Cho, SW=32967447200 | en_US |
dc.identifier.scopusauthorid | Jung, HS=7403030195 | en_US |
dc.identifier.scopusauthorid | Park, KT=7408066901 | en_US |
dc.identifier.scopusauthorid | Son, HK=12769270800 | en_US |
dc.identifier.citeulike | 3374120 | - |
dc.identifier.issnl | 1354-523X | - |