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Article: Comparative analysis of ABCG2-expressing and label-retaining cells in mouse submandibular gland

TitleComparative analysis of ABCG2-expressing and label-retaining cells in mouse submandibular gland
Authors
Issue Date2008
PublisherSpringer Verlag. The Journal's web site is located at http://link.springer.de/link/service/journals/00441/index.htm
Citation
Cell And Tissue Research, 2008, v. 334 n. 1, p. 47-53 How to Cite?
AbstractThe submandibular gland (SMG) is a tissue that can be regenerated in a tissue injury model and that has adult stem cells capable of self-renewal and differentiation into functional cells. We have analyzed the localization of label-retaining cells (LRCs), which are putative progenitor cells, by using the BrdU-labeling method. 5-Bromo-2′-deoxyuridine (BrdU) injection followed by a long chasing period permitted the identification of LRCs based on the slow-cycling characteristic. In order to confirm the accurate localization of LRCs, BrdU and SMG-specific markers, including aquaporin5, cytokeratin, and smooth muscle actin, were examined by double-immunofluoresence staining. We found that LRCs were distributed in the acinus, duct, myoepithelium, and connective tissue. Moreover, ABCG2 (a known stem cell marker) was used for the characterization of LRCs and the localization of cells as putative stem/progenitor cells. ABCG2-expressing cells were distributed in various regions of the SMG but did not co-localize with LRCs. We suggest that putative progenitor cells exist in various regions of the SMG and have diverse capacities to differentiate into specific cells. © 2008 Springer-Verlag.
Persistent Identifierhttp://hdl.handle.net/10722/169549
ISSN
2015 Impact Factor: 2.948
2015 SCImago Journal Rankings: 1.539
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorKim, YJen_US
dc.contributor.authorKwon, HJen_US
dc.contributor.authorShinozaki, Nen_US
dc.contributor.authorHashimoto, Sen_US
dc.contributor.authorShimono, Men_US
dc.contributor.authorCho, SWen_US
dc.contributor.authorJung, HSen_US
dc.date.accessioned2012-10-25T04:52:46Z-
dc.date.available2012-10-25T04:52:46Z-
dc.date.issued2008en_US
dc.identifier.citationCell And Tissue Research, 2008, v. 334 n. 1, p. 47-53en_US
dc.identifier.issn0302-766Xen_US
dc.identifier.urihttp://hdl.handle.net/10722/169549-
dc.description.abstractThe submandibular gland (SMG) is a tissue that can be regenerated in a tissue injury model and that has adult stem cells capable of self-renewal and differentiation into functional cells. We have analyzed the localization of label-retaining cells (LRCs), which are putative progenitor cells, by using the BrdU-labeling method. 5-Bromo-2′-deoxyuridine (BrdU) injection followed by a long chasing period permitted the identification of LRCs based on the slow-cycling characteristic. In order to confirm the accurate localization of LRCs, BrdU and SMG-specific markers, including aquaporin5, cytokeratin, and smooth muscle actin, were examined by double-immunofluoresence staining. We found that LRCs were distributed in the acinus, duct, myoepithelium, and connective tissue. Moreover, ABCG2 (a known stem cell marker) was used for the characterization of LRCs and the localization of cells as putative stem/progenitor cells. ABCG2-expressing cells were distributed in various regions of the SMG but did not co-localize with LRCs. We suggest that putative progenitor cells exist in various regions of the SMG and have diverse capacities to differentiate into specific cells. © 2008 Springer-Verlag.en_US
dc.languageengen_US
dc.publisherSpringer Verlag. The Journal's web site is located at http://link.springer.de/link/service/journals/00441/index.htmen_US
dc.relation.ispartofCell and Tissue Researchen_US
dc.subject.meshAtp-Binding Cassette Transporters - Biosynthesisen_US
dc.subject.meshActins - Metabolismen_US
dc.subject.meshAnimalsen_US
dc.subject.meshAquaporin 5 - Metabolismen_US
dc.subject.meshBromodeoxyuridine - Chemistryen_US
dc.subject.meshKeratins - Metabolismen_US
dc.subject.meshMiceen_US
dc.subject.meshMice, Inbred Icren_US
dc.subject.meshStem Cells - Cytology - Metabolismen_US
dc.subject.meshSubmandibular Gland - Cytology - Metabolismen_US
dc.titleComparative analysis of ABCG2-expressing and label-retaining cells in mouse submandibular glanden_US
dc.typeArticleen_US
dc.identifier.emailJung, HS: hsjung@yuhs.acen_US
dc.identifier.authorityJung, HS=rp01683en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1007/s00441-008-0667-8en_US
dc.identifier.pmid18688650-
dc.identifier.scopuseid_2-s2.0-51749116278en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-51749116278&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume334en_US
dc.identifier.issue1en_US
dc.identifier.spage47en_US
dc.identifier.epage53en_US
dc.identifier.isiWOS:000259141500006-
dc.publisher.placeGermanyen_US
dc.identifier.scopusauthoridKim, YJ=16833275700en_US
dc.identifier.scopusauthoridKwon, HJ=18836582500en_US
dc.identifier.scopusauthoridShinozaki, N=7006255698en_US
dc.identifier.scopusauthoridHashimoto, S=35556628400en_US
dc.identifier.scopusauthoridShimono, M=7006406232en_US
dc.identifier.scopusauthoridCho, SW=32967447200en_US
dc.identifier.scopusauthoridJung, HS=7403030195en_US

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