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Article: Expression of phosphorylated forms of ERK, MEK, PTEN and PI3K in mouse oral development

TitleExpression of phosphorylated forms of ERK, MEK, PTEN and PI3K in mouse oral development
Authors
Issue Date2008
PublisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/modgep
Citation
Gene Expression Patterns, 2008, v. 8 n. 4, p. 284-290 How to Cite?
AbstractInvestigations into molecular mechanisms in vertebrates have examined which growth factors regulate many of the essential underlying cellular processes in development. Growth factors regulate cell proliferation and differentiation through diverse signaling pathways like the MEK (mitogen-activated protein kinase) and ERK (extracellular signal-regulated kinase) pathway. The MEK and ERK pathway can interact with the PI3K (phosphatidylinositol-3-kinase) and PTEN (phosphatase and tensin homologues deleted on chromosome 10) signaling pathway. Interactions between these pathways during development have been extensively studied in many organs; however, the importance of these pathways in oral development is not well known. In this study, we examined the expression of the phosphorylated forms of ERK (pERK), MEK (pMEK), PTEN (pPTEN) and PI3K during mouse development from E13.5 to E16.5. We found unique and overlapping expression of these factors in the craniofacial region, with pERK and pPTEN showing opposing activation patterns in both the tooth and the tongue. © 2008 Elsevier B.V. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/169547
ISSN
2015 Impact Factor: 1.485
2015 SCImago Journal Rankings: 0.985
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorCho, KWen_US
dc.contributor.authorCho, SWen_US
dc.contributor.authorLee, JMen_US
dc.contributor.authorLee, MJen_US
dc.contributor.authorGang, HSen_US
dc.contributor.authorJung, HSen_US
dc.date.accessioned2012-10-25T04:52:45Z-
dc.date.available2012-10-25T04:52:45Z-
dc.date.issued2008en_US
dc.identifier.citationGene Expression Patterns, 2008, v. 8 n. 4, p. 284-290en_US
dc.identifier.issn1567-133Xen_US
dc.identifier.urihttp://hdl.handle.net/10722/169547-
dc.description.abstractInvestigations into molecular mechanisms in vertebrates have examined which growth factors regulate many of the essential underlying cellular processes in development. Growth factors regulate cell proliferation and differentiation through diverse signaling pathways like the MEK (mitogen-activated protein kinase) and ERK (extracellular signal-regulated kinase) pathway. The MEK and ERK pathway can interact with the PI3K (phosphatidylinositol-3-kinase) and PTEN (phosphatase and tensin homologues deleted on chromosome 10) signaling pathway. Interactions between these pathways during development have been extensively studied in many organs; however, the importance of these pathways in oral development is not well known. In this study, we examined the expression of the phosphorylated forms of ERK (pERK), MEK (pMEK), PTEN (pPTEN) and PI3K during mouse development from E13.5 to E16.5. We found unique and overlapping expression of these factors in the craniofacial region, with pERK and pPTEN showing opposing activation patterns in both the tooth and the tongue. © 2008 Elsevier B.V. All rights reserved.en_US
dc.languageengen_US
dc.publisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/modgepen_US
dc.relation.ispartofGene Expression Patternsen_US
dc.subject.meshAnimalsen_US
dc.subject.meshExtracellular Signal-Regulated Map Kinases - Metabolismen_US
dc.subject.meshImmunohistochemistryen_US
dc.subject.meshMiceen_US
dc.subject.meshMitogen-Activated Protein Kinase Kinases - Metabolismen_US
dc.subject.meshMouth - Embryology - Enzymologyen_US
dc.subject.meshPten Phosphohydrolase - Metabolismen_US
dc.subject.meshPalate - Embryology - Enzymologyen_US
dc.subject.meshPhosphatidylinositol 3-Kinases - Metabolismen_US
dc.subject.meshPhosphorylationen_US
dc.subject.meshTongue - Embryology - Enzymologyen_US
dc.subject.meshTooth - Embryology - Enzymologyen_US
dc.titleExpression of phosphorylated forms of ERK, MEK, PTEN and PI3K in mouse oral developmenten_US
dc.typeArticleen_US
dc.identifier.emailJung, HS: hsjung@yuhs.acen_US
dc.identifier.authorityJung, HS=rp01683en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/j.gep.2007.12.001en_US
dc.identifier.pmid18203667-
dc.identifier.scopuseid_2-s2.0-39649123721en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-39649123721&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume8en_US
dc.identifier.issue4en_US
dc.identifier.spage284en_US
dc.identifier.epage290en_US
dc.identifier.isiWOS:000254697000009-
dc.publisher.placeNetherlandsen_US
dc.identifier.scopusauthoridCho, KW=7403956665en_US
dc.identifier.scopusauthoridCho, SW=32967447200en_US
dc.identifier.scopusauthoridLee, JM=25622544900en_US
dc.identifier.scopusauthoridLee, MJ=35264472100en_US
dc.identifier.scopusauthoridGang, HS=23570569000en_US
dc.identifier.scopusauthoridJung, HS=7403030195en_US

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