Article: Wnt11/Fgfr1b cross-talk modulates the fate of cells in palate development

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TitleWnt11/Fgfr1b cross-talk modulates the fate of cells in palate development
AuthorsLee, JM1
Kim, JY1 2
Cho, KW1
Lee, MJ1
Cho, SW1
Kwak, S1
Cai, J1
Jung, HS1
Issue Date2008
PublisherAcademic Press. The Journal's web site is located at http://www.elsevier.com/locate/ydbio
CitationDevelopmental Biology, 2008, v. 314 n. 2, p. 341-350 [How to Cite?]
DOI: http://dx.doi.org/10.1016/j.ydbio.2007.11.033
AbstractVarious cellular and molecular events underlie the elevation and fusion of the developing palate that occurs during embryonic development. This includes convergent extension, where the medial edge epithelium is intercalated into the midline epithelial seam. We examined the expression patterns of Wnt11 and Fgfr1b - which are believed to be key factors in convergent extension - in mouse palate development. Wnt-11 overexpression and beads soaked in SU5402 (an Fgfr1 inhibitor) were employed in in vitro organ cultures. The results suggested that interactions between Wnt11 and Fgfr1b are important in modulating cellular events such as cell proliferation for growth and apoptosis for fusion. Moreover, the Wnt11 siRNA results showed that Wnt11-induced apoptosis was necessary for palatal fusion. In summary, Fgfr1b induces cell proliferation in the developing palate mesenchyme so that the palate grows and contacts each palatal shelf, with negative feedback of Fgfs triggered by excessive cell proliferation then inhibiting the expression of Fgfr1b and activating the expression of Wnt11 to fuse each palate by activating apoptosis. © 2007 Elsevier Inc. All rights reserved.
ISSN0012-1606
2011 Impact Factor: 4.069
2011 SCImago Journal Rankings: 0.877
DOIhttp://dx.doi.org/10.1016/j.ydbio.2007.11.033
ReferencesReferences in Scopus
DC Field
Value
dc.contributor.authorLee, JM
dc.contributor.authorKim, JY
dc.contributor.authorCho, KW
dc.contributor.authorLee, MJ
dc.contributor.authorCho, SW
dc.contributor.authorKwak, S
dc.contributor.authorCai, J
dc.contributor.authorJung, HS
dc.date.accessioned2012-10-25T04:52:45Z
dc.date.available2012-10-25T04:52:45Z
dc.date.issued2008
dc.description.abstractVarious cellular and molecular events underlie the elevation and fusion of the developing palate that occurs during embryonic development. This includes convergent extension, where the medial edge epithelium is intercalated into the midline epithelial seam. We examined the expression patterns of Wnt11 and Fgfr1b - which are believed to be key factors in convergent extension - in mouse palate development. Wnt-11 overexpression and beads soaked in SU5402 (an Fgfr1 inhibitor) were employed in in vitro organ cultures. The results suggested that interactions between Wnt11 and Fgfr1b are important in modulating cellular events such as cell proliferation for growth and apoptosis for fusion. Moreover, the Wnt11 siRNA results showed that Wnt11-induced apoptosis was necessary for palatal fusion. In summary, Fgfr1b induces cell proliferation in the developing palate mesenchyme so that the palate grows and contacts each palatal shelf, with negative feedback of Fgfs triggered by excessive cell proliferation then inhibiting the expression of Fgfr1b and activating the expression of Wnt11 to fuse each palate by activating apoptosis. © 2007 Elsevier Inc. All rights reserved.
dc.description.natureLink_to_subscribed_fulltext
dc.identifier.citationDevelopmental Biology, 2008, v. 314 n. 2, p. 341-350 [How to Cite?]
DOI: http://dx.doi.org/10.1016/j.ydbio.2007.11.033
dc.identifier.citeulike5650786
dc.identifier.doihttp://dx.doi.org/10.1016/j.ydbio.2007.11.033
dc.identifier.epage350
dc.identifier.issn0012-1606
2011 Impact Factor: 4.069
2011 SCImago Journal Rankings: 0.877
dc.identifier.issue2
dc.identifier.pmid18191119
dc.identifier.scopuseid_2-s2.0-38849174513
dc.identifier.spage341
dc.identifier.urihttp://hdl.handle.net/10722/169546
dc.identifier.volume314
dc.languageeng
dc.publisherAcademic Press. The Journal's web site is located at http://www.elsevier.com/locate/ydbio
dc.publisher.placeUnited States
dc.relation.ispartofDevelopmental Biology
dc.relation.referencesReferences in Scopus
dc.subject.meshAging - Physiology
dc.subject.meshAnimals
dc.subject.meshElectroporation
dc.subject.meshImmunohistochemistry
dc.subject.meshIn Situ Hybridization
dc.subject.meshMaxilla - Cytology - Growth & Development
dc.subject.meshMice
dc.subject.meshMice, Inbred Icr
dc.subject.meshOrgan Culture Techniques
dc.subject.meshPalate - Cytology - Growth & Development
dc.subject.meshPolymerase Chain Reaction
dc.subject.meshRna, Small Interfering - Genetics
dc.subject.meshReceptor Cross-Talk - Physiology
dc.subject.meshReceptor, Fibroblast Growth Factor, Type 1 - Genetics - Physiology
dc.subject.meshWnt Proteins - Genetics - Physiology
dc.titleWnt11/Fgfr1b cross-talk modulates the fate of cells in palate development
dc.typeArticle
Author Affiliations
  1. Research Center for Orofacial Hard Tissue Regeneration
  2. Kyungpook National University