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Article: Wnt11/Fgfr1b cross-talk modulates the fate of cells in palate development

TitleWnt11/Fgfr1b cross-talk modulates the fate of cells in palate development
Authors
Issue Date2008
PublisherAcademic Press. The Journal's web site is located at http://www.elsevier.com/locate/ydbio
Citation
Developmental Biology, 2008, v. 314 n. 2, p. 341-350 How to Cite?
AbstractVarious cellular and molecular events underlie the elevation and fusion of the developing palate that occurs during embryonic development. This includes convergent extension, where the medial edge epithelium is intercalated into the midline epithelial seam. We examined the expression patterns of Wnt11 and Fgfr1b - which are believed to be key factors in convergent extension - in mouse palate development. Wnt-11 overexpression and beads soaked in SU5402 (an Fgfr1 inhibitor) were employed in in vitro organ cultures. The results suggested that interactions between Wnt11 and Fgfr1b are important in modulating cellular events such as cell proliferation for growth and apoptosis for fusion. Moreover, the Wnt11 siRNA results showed that Wnt11-induced apoptosis was necessary for palatal fusion. In summary, Fgfr1b induces cell proliferation in the developing palate mesenchyme so that the palate grows and contacts each palatal shelf, with negative feedback of Fgfs triggered by excessive cell proliferation then inhibiting the expression of Fgfr1b and activating the expression of Wnt11 to fuse each palate by activating apoptosis. © 2007 Elsevier Inc. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/169546
ISSN
2014 Impact Factor: 3.547
2014 SCImago Journal Rankings: 2.122
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorLee, JMen_US
dc.contributor.authorKim, JYen_US
dc.contributor.authorCho, KWen_US
dc.contributor.authorLee, MJen_US
dc.contributor.authorCho, SWen_US
dc.contributor.authorKwak, Sen_US
dc.contributor.authorCai, Jen_US
dc.contributor.authorJung, HSen_US
dc.date.accessioned2012-10-25T04:52:45Z-
dc.date.available2012-10-25T04:52:45Z-
dc.date.issued2008en_US
dc.identifier.citationDevelopmental Biology, 2008, v. 314 n. 2, p. 341-350en_US
dc.identifier.issn0012-1606en_US
dc.identifier.urihttp://hdl.handle.net/10722/169546-
dc.description.abstractVarious cellular and molecular events underlie the elevation and fusion of the developing palate that occurs during embryonic development. This includes convergent extension, where the medial edge epithelium is intercalated into the midline epithelial seam. We examined the expression patterns of Wnt11 and Fgfr1b - which are believed to be key factors in convergent extension - in mouse palate development. Wnt-11 overexpression and beads soaked in SU5402 (an Fgfr1 inhibitor) were employed in in vitro organ cultures. The results suggested that interactions between Wnt11 and Fgfr1b are important in modulating cellular events such as cell proliferation for growth and apoptosis for fusion. Moreover, the Wnt11 siRNA results showed that Wnt11-induced apoptosis was necessary for palatal fusion. In summary, Fgfr1b induces cell proliferation in the developing palate mesenchyme so that the palate grows and contacts each palatal shelf, with negative feedback of Fgfs triggered by excessive cell proliferation then inhibiting the expression of Fgfr1b and activating the expression of Wnt11 to fuse each palate by activating apoptosis. © 2007 Elsevier Inc. All rights reserved.en_US
dc.languageengen_US
dc.publisherAcademic Press. The Journal's web site is located at http://www.elsevier.com/locate/ydbioen_US
dc.relation.ispartofDevelopmental Biologyen_US
dc.subject.meshAging - Physiologyen_US
dc.subject.meshAnimalsen_US
dc.subject.meshElectroporationen_US
dc.subject.meshImmunohistochemistryen_US
dc.subject.meshIn Situ Hybridizationen_US
dc.subject.meshMaxilla - Cytology - Growth & Developmenten_US
dc.subject.meshMiceen_US
dc.subject.meshMice, Inbred Icren_US
dc.subject.meshOrgan Culture Techniquesen_US
dc.subject.meshPalate - Cytology - Growth & Developmenten_US
dc.subject.meshPolymerase Chain Reactionen_US
dc.subject.meshRna, Small Interfering - Geneticsen_US
dc.subject.meshReceptor Cross-Talk - Physiologyen_US
dc.subject.meshReceptor, Fibroblast Growth Factor, Type 1 - Genetics - Physiologyen_US
dc.subject.meshWnt Proteins - Genetics - Physiologyen_US
dc.titleWnt11/Fgfr1b cross-talk modulates the fate of cells in palate developmenten_US
dc.typeArticleen_US
dc.identifier.emailJung, HS: hsjung@yuhs.acen_US
dc.identifier.authorityJung, HS=rp01683en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/j.ydbio.2007.11.033en_US
dc.identifier.pmid18191119-
dc.identifier.scopuseid_2-s2.0-38849174513en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-38849174513&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume314en_US
dc.identifier.issue2en_US
dc.identifier.spage341en_US
dc.identifier.epage350en_US
dc.identifier.isiWOS:000253334000008-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridLee, JM=25622544900en_US
dc.identifier.scopusauthoridKim, JY=7601361822en_US
dc.identifier.scopusauthoridCho, KW=7403956665en_US
dc.identifier.scopusauthoridLee, MJ=35264472100en_US
dc.identifier.scopusauthoridCho, SW=32967447200en_US
dc.identifier.scopusauthoridKwak, S=7202607781en_US
dc.identifier.scopusauthoridCai, J=9246458800en_US
dc.identifier.scopusauthoridJung, HS=7403030195en_US
dc.identifier.citeulike5650786-

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