File Download
 
Links for fulltext
(May Require Subscription)
 
Supplementary

Article: Wnt11/Fgfr1b cross-talk modulates the fate of cells in palate development
  • Basic View
  • Metadata View
  • XML View
TitleWnt11/Fgfr1b cross-talk modulates the fate of cells in palate development
 
AuthorsLee, JM1
Kim, JY1 2
Cho, KW1
Lee, MJ1
Cho, SW1
Kwak, S1
Cai, J1
Jung, HS1
 
Issue Date2008
 
PublisherAcademic Press. The Journal's web site is located at http://www.elsevier.com/locate/ydbio
 
CitationDevelopmental Biology, 2008, v. 314 n. 2, p. 341-350 [How to Cite?]
DOI: http://dx.doi.org/10.1016/j.ydbio.2007.11.033
 
AbstractVarious cellular and molecular events underlie the elevation and fusion of the developing palate that occurs during embryonic development. This includes convergent extension, where the medial edge epithelium is intercalated into the midline epithelial seam. We examined the expression patterns of Wnt11 and Fgfr1b - which are believed to be key factors in convergent extension - in mouse palate development. Wnt-11 overexpression and beads soaked in SU5402 (an Fgfr1 inhibitor) were employed in in vitro organ cultures. The results suggested that interactions between Wnt11 and Fgfr1b are important in modulating cellular events such as cell proliferation for growth and apoptosis for fusion. Moreover, the Wnt11 siRNA results showed that Wnt11-induced apoptosis was necessary for palatal fusion. In summary, Fgfr1b induces cell proliferation in the developing palate mesenchyme so that the palate grows and contacts each palatal shelf, with negative feedback of Fgfs triggered by excessive cell proliferation then inhibiting the expression of Fgfr1b and activating the expression of Wnt11 to fuse each palate by activating apoptosis. © 2007 Elsevier Inc. All rights reserved.
 
ISSN0012-1606
2013 Impact Factor: 3.637
 
DOIhttp://dx.doi.org/10.1016/j.ydbio.2007.11.033
 
ReferencesReferences in Scopus
 
DC FieldValue
dc.contributor.authorLee, JM
 
dc.contributor.authorKim, JY
 
dc.contributor.authorCho, KW
 
dc.contributor.authorLee, MJ
 
dc.contributor.authorCho, SW
 
dc.contributor.authorKwak, S
 
dc.contributor.authorCai, J
 
dc.contributor.authorJung, HS
 
dc.date.accessioned2012-10-25T04:52:45Z
 
dc.date.available2012-10-25T04:52:45Z
 
dc.date.issued2008
 
dc.description.abstractVarious cellular and molecular events underlie the elevation and fusion of the developing palate that occurs during embryonic development. This includes convergent extension, where the medial edge epithelium is intercalated into the midline epithelial seam. We examined the expression patterns of Wnt11 and Fgfr1b - which are believed to be key factors in convergent extension - in mouse palate development. Wnt-11 overexpression and beads soaked in SU5402 (an Fgfr1 inhibitor) were employed in in vitro organ cultures. The results suggested that interactions between Wnt11 and Fgfr1b are important in modulating cellular events such as cell proliferation for growth and apoptosis for fusion. Moreover, the Wnt11 siRNA results showed that Wnt11-induced apoptosis was necessary for palatal fusion. In summary, Fgfr1b induces cell proliferation in the developing palate mesenchyme so that the palate grows and contacts each palatal shelf, with negative feedback of Fgfs triggered by excessive cell proliferation then inhibiting the expression of Fgfr1b and activating the expression of Wnt11 to fuse each palate by activating apoptosis. © 2007 Elsevier Inc. All rights reserved.
 
dc.description.naturelink_to_subscribed_fulltext
 
dc.identifier.citationDevelopmental Biology, 2008, v. 314 n. 2, p. 341-350 [How to Cite?]
DOI: http://dx.doi.org/10.1016/j.ydbio.2007.11.033
 
dc.identifier.citeulike5650786
 
dc.identifier.doihttp://dx.doi.org/10.1016/j.ydbio.2007.11.033
 
dc.identifier.epage350
 
dc.identifier.issn0012-1606
2013 Impact Factor: 3.637
 
dc.identifier.issue2
 
dc.identifier.pmid18191119
 
dc.identifier.scopuseid_2-s2.0-38849174513
 
dc.identifier.spage341
 
dc.identifier.urihttp://hdl.handle.net/10722/169546
 
dc.identifier.volume314
 
dc.languageeng
 
dc.publisherAcademic Press. The Journal's web site is located at http://www.elsevier.com/locate/ydbio
 
dc.publisher.placeUnited States
 
dc.relation.ispartofDevelopmental Biology
 
dc.relation.referencesReferences in Scopus
 
dc.subject.meshAging - Physiology
 
dc.subject.meshAnimals
 
dc.subject.meshElectroporation
 
dc.subject.meshImmunohistochemistry
 
dc.subject.meshIn Situ Hybridization
 
dc.subject.meshMaxilla - Cytology - Growth & Development
 
dc.subject.meshMice
 
dc.subject.meshMice, Inbred Icr
 
dc.subject.meshOrgan Culture Techniques
 
dc.subject.meshPalate - Cytology - Growth & Development
 
dc.subject.meshPolymerase Chain Reaction
 
dc.subject.meshRna, Small Interfering - Genetics
 
dc.subject.meshReceptor Cross-Talk - Physiology
 
dc.subject.meshReceptor, Fibroblast Growth Factor, Type 1 - Genetics - Physiology
 
dc.subject.meshWnt Proteins - Genetics - Physiology
 
dc.titleWnt11/Fgfr1b cross-talk modulates the fate of cells in palate development
 
dc.typeArticle
 
<?xml encoding="utf-8" version="1.0"?>
<item><contributor.author>Lee, JM</contributor.author>
<contributor.author>Kim, JY</contributor.author>
<contributor.author>Cho, KW</contributor.author>
<contributor.author>Lee, MJ</contributor.author>
<contributor.author>Cho, SW</contributor.author>
<contributor.author>Kwak, S</contributor.author>
<contributor.author>Cai, J</contributor.author>
<contributor.author>Jung, HS</contributor.author>
<date.accessioned>2012-10-25T04:52:45Z</date.accessioned>
<date.available>2012-10-25T04:52:45Z</date.available>
<date.issued>2008</date.issued>
<identifier.citation>Developmental Biology, 2008, v. 314 n. 2, p. 341-350</identifier.citation>
<identifier.issn>0012-1606</identifier.issn>
<identifier.uri>http://hdl.handle.net/10722/169546</identifier.uri>
<description.abstract>Various cellular and molecular events underlie the elevation and fusion of the developing palate that occurs during embryonic development. This includes convergent extension, where the medial edge epithelium is intercalated into the midline epithelial seam. We examined the expression patterns of Wnt11 and Fgfr1b - which are believed to be key factors in convergent extension - in mouse palate development. Wnt-11 overexpression and beads soaked in SU5402 (an Fgfr1 inhibitor) were employed in in vitro organ cultures. The results suggested that interactions between Wnt11 and Fgfr1b are important in modulating cellular events such as cell proliferation for growth and apoptosis for fusion. Moreover, the Wnt11 siRNA results showed that Wnt11-induced apoptosis was necessary for palatal fusion. In summary, Fgfr1b induces cell proliferation in the developing palate mesenchyme so that the palate grows and contacts each palatal shelf, with negative feedback of Fgfs triggered by excessive cell proliferation then inhibiting the expression of Fgfr1b and activating the expression of Wnt11 to fuse each palate by activating apoptosis. &#169; 2007 Elsevier Inc. All rights reserved.</description.abstract>
<language>eng</language>
<publisher>Academic Press. The Journal&apos;s web site is located at http://www.elsevier.com/locate/ydbio</publisher>
<relation.ispartof>Developmental Biology</relation.ispartof>
<subject.mesh>Aging - Physiology</subject.mesh>
<subject.mesh>Animals</subject.mesh>
<subject.mesh>Electroporation</subject.mesh>
<subject.mesh>Immunohistochemistry</subject.mesh>
<subject.mesh>In Situ Hybridization</subject.mesh>
<subject.mesh>Maxilla - Cytology - Growth &amp; Development</subject.mesh>
<subject.mesh>Mice</subject.mesh>
<subject.mesh>Mice, Inbred Icr</subject.mesh>
<subject.mesh>Organ Culture Techniques</subject.mesh>
<subject.mesh>Palate - Cytology - Growth &amp; Development</subject.mesh>
<subject.mesh>Polymerase Chain Reaction</subject.mesh>
<subject.mesh>Rna, Small Interfering - Genetics</subject.mesh>
<subject.mesh>Receptor Cross-Talk - Physiology</subject.mesh>
<subject.mesh>Receptor, Fibroblast Growth Factor, Type 1 - Genetics - Physiology</subject.mesh>
<subject.mesh>Wnt Proteins - Genetics - Physiology</subject.mesh>
<title>Wnt11/Fgfr1b cross-talk modulates the fate of cells in palate development</title>
<type>Article</type>
<description.nature>link_to_subscribed_fulltext</description.nature>
<identifier.doi>10.1016/j.ydbio.2007.11.033</identifier.doi>
<identifier.pmid>18191119</identifier.pmid>
<identifier.scopus>eid_2-s2.0-38849174513</identifier.scopus>
<relation.references>http://www.scopus.com/mlt/select.url?eid=2-s2.0-38849174513&amp;selection=ref&amp;src=s&amp;origin=recordpage</relation.references>
<identifier.volume>314</identifier.volume>
<identifier.issue>2</identifier.issue>
<identifier.spage>341</identifier.spage>
<identifier.epage>350</identifier.epage>
<publisher.place>United States</publisher.place>
<identifier.citeulike>5650786</identifier.citeulike>
</item>
Author Affiliations
  1. Research Center for Orofacial Hard Tissue Regeneration
  2. Kyungpook National University