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Article: Cusp patterning defect in Tabby mouse teeth and its partial rescue by FGF

TitleCusp patterning defect in Tabby mouse teeth and its partial rescue by FGF
Authors
Issue Date1999
PublisherAcademic Press. The Journal's web site is located at http://www.elsevier.com/locate/ydbio
Citation
Developmental Biology, 1999, v. 216 n. 2, p. 521-534 How to Cite?
AbstractTabby is a mouse mutant characterized by deficient development of the ectodermal organs: teeth, hair, and a subset of glands. Ectodysplasin, the protein encoded by the Tabby gene, was recently identified as a novel TNF- like transmembrane protein but little is known about its function. We have examined the Tabby tooth phenotype in detail by analysis of the adult and embryonic teeth. Tabby first molars had an obvious defect in cusp patterning as the number of cusps was reduced and the buccal and lingual cusps were joined. The disturbance in development was first visible morphologically in the bud stage molar. The primary enamel knot in a cap stage Tabby tooth expressed all enamel knot markers analyzed but was smaller than wild type and the first pair of developing secondary enamel knots was fused. We propose that the Tabby tooth phenotype is due to growth retardation during early stages of development which leads to reduced signaling from the primary enamel knot, followed by deficient growth of the dental epithelium and lack of formation of the last developing secondary enamel knots. The ectodysplasin transcripts were expressed in the outer enamel epithelium and dental lamina. When cultured in vitro Tabby bud/cap stage molars formed fewer cusps than wild-type controls. This phenotype was not rescued by exogenously added EGF despite the previously proposed link between Tabby and EGF. Instead FGF-10 partially restored morphogenesis and stimulated the development of additional tooth cusps in cultured Tabby molars.
Persistent Identifierhttp://hdl.handle.net/10722/169535
ISSN
2015 Impact Factor: 3.155
2015 SCImago Journal Rankings: 2.554
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorPispa, Jen_US
dc.contributor.authorJung, HSen_US
dc.contributor.authorJernvall, Jen_US
dc.contributor.authorKettunen, Pen_US
dc.contributor.authorMustonen, Ten_US
dc.contributor.authorTabata, MJen_US
dc.contributor.authorKere, Jen_US
dc.contributor.authorThesleff, Ien_US
dc.date.accessioned2012-10-25T04:52:37Z-
dc.date.available2012-10-25T04:52:37Z-
dc.date.issued1999en_US
dc.identifier.citationDevelopmental Biology, 1999, v. 216 n. 2, p. 521-534en_US
dc.identifier.issn0012-1606en_US
dc.identifier.urihttp://hdl.handle.net/10722/169535-
dc.description.abstractTabby is a mouse mutant characterized by deficient development of the ectodermal organs: teeth, hair, and a subset of glands. Ectodysplasin, the protein encoded by the Tabby gene, was recently identified as a novel TNF- like transmembrane protein but little is known about its function. We have examined the Tabby tooth phenotype in detail by analysis of the adult and embryonic teeth. Tabby first molars had an obvious defect in cusp patterning as the number of cusps was reduced and the buccal and lingual cusps were joined. The disturbance in development was first visible morphologically in the bud stage molar. The primary enamel knot in a cap stage Tabby tooth expressed all enamel knot markers analyzed but was smaller than wild type and the first pair of developing secondary enamel knots was fused. We propose that the Tabby tooth phenotype is due to growth retardation during early stages of development which leads to reduced signaling from the primary enamel knot, followed by deficient growth of the dental epithelium and lack of formation of the last developing secondary enamel knots. The ectodysplasin transcripts were expressed in the outer enamel epithelium and dental lamina. When cultured in vitro Tabby bud/cap stage molars formed fewer cusps than wild-type controls. This phenotype was not rescued by exogenously added EGF despite the previously proposed link between Tabby and EGF. Instead FGF-10 partially restored morphogenesis and stimulated the development of additional tooth cusps in cultured Tabby molars.en_US
dc.languageengen_US
dc.publisherAcademic Press. The Journal's web site is located at http://www.elsevier.com/locate/ydbioen_US
dc.relation.ispartofDevelopmental Biologyen_US
dc.subject.meshAnimalsen_US
dc.subject.meshBone Morphogenetic Proteins - Genetics - Metabolismen_US
dc.subject.meshDental Enamel - Pathologyen_US
dc.subject.meshEctoderm - Pathologyen_US
dc.subject.meshEctodysplasinsen_US
dc.subject.meshFibroblast Growth Factors - Pharmacologyen_US
dc.subject.meshGene Expression Regulation, Developmentalen_US
dc.subject.meshImmunohistochemistryen_US
dc.subject.meshIn Situ Hybridizationen_US
dc.subject.meshMembrane Proteins - Geneticsen_US
dc.subject.meshMiceen_US
dc.subject.meshMice, Inbred Strainsen_US
dc.subject.meshMorphogenesisen_US
dc.subject.meshMutationen_US
dc.subject.meshPhenotypeen_US
dc.subject.meshRna, Messenger - Metabolismen_US
dc.subject.meshSignal Transductionen_US
dc.subject.meshTooth - Embryology - Pathologyen_US
dc.titleCusp patterning defect in Tabby mouse teeth and its partial rescue by FGFen_US
dc.typeArticleen_US
dc.identifier.emailJung, HS: hsjung@yuhs.acen_US
dc.identifier.authorityJung, HS=rp01683en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1006/dbio.1999.9514en_US
dc.identifier.pmid10642790-
dc.identifier.scopuseid_2-s2.0-0033572260en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0033572260&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume216en_US
dc.identifier.issue2en_US
dc.identifier.spage521en_US
dc.identifier.epage534en_US
dc.identifier.isiWOS:000084591200008-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridPispa, J=24342045800en_US
dc.identifier.scopusauthoridJung, HS=7403030195en_US
dc.identifier.scopusauthoridJernvall, J=6603722003en_US
dc.identifier.scopusauthoridKettunen, P=35902540000en_US
dc.identifier.scopusauthoridMustonen, T=6603088419en_US
dc.identifier.scopusauthoridTabata, MJ=7201900504en_US
dc.identifier.scopusauthoridKere, J=7005922099en_US
dc.identifier.scopusauthoridThesleff, I=7005319521en_US

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