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Article: Self-organization of periodic patterns by dissociated feather mesenchymal cells and the regulation of size, number and spacing of primordia

TitleSelf-organization of periodic patterns by dissociated feather mesenchymal cells and the regulation of size, number and spacing of primordia
Authors
Issue Date1999
PublisherThe Company of Biologists Ltd. The Journal's web site is located at http://dev.biologists.org
Citation
Development, 1999, v. 126 n. 22, p. 4997-5009 How to Cite?
AbstractPeriodic patterning is a fundamental organizing process in biology. Using a feather reconstitution assay, we traced back to the initial stage of the patterning process. Cells started from an equivalent state and self-organized into a periodic pattern without previous cues or sequential propagation. When different numbers of dissociated mesenchymal cells were confronted with a piece of same-sized epithelium, the size of feather primordia remained constant, not the number or interbud spacing, suggesting size determination is intrinsic to dissociated cells. Increasing bone morphogenetic protein (BMP) receptor expression in mesenchymal cells decreased the size of primordia while antagonizing the BMP pathway with Noggin increased the size of primordia. A threshold number of mesenchymal cells with a basal level of adhesion molecules such as NCAM were sufficient to trigger the patterning process. The process is best visualized by the progressive restriction of β-catenin transcripts in the epidermis. Therefore, feather size, number and spacing are modulated through the available morphogen ligands and receptors in the system.
Persistent Identifierhttp://hdl.handle.net/10722/169533
ISSN
2015 Impact Factor: 6.059
2015 SCImago Journal Rankings: 5.239
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorJiang, TXen_US
dc.contributor.authorJung, HSen_US
dc.contributor.authorWidelitz, RBen_US
dc.contributor.authorChuong, CMen_US
dc.date.accessioned2012-10-25T04:52:36Z-
dc.date.available2012-10-25T04:52:36Z-
dc.date.issued1999en_US
dc.identifier.citationDevelopment, 1999, v. 126 n. 22, p. 4997-5009en_US
dc.identifier.issn0950-1991en_US
dc.identifier.urihttp://hdl.handle.net/10722/169533-
dc.description.abstractPeriodic patterning is a fundamental organizing process in biology. Using a feather reconstitution assay, we traced back to the initial stage of the patterning process. Cells started from an equivalent state and self-organized into a periodic pattern without previous cues or sequential propagation. When different numbers of dissociated mesenchymal cells were confronted with a piece of same-sized epithelium, the size of feather primordia remained constant, not the number or interbud spacing, suggesting size determination is intrinsic to dissociated cells. Increasing bone morphogenetic protein (BMP) receptor expression in mesenchymal cells decreased the size of primordia while antagonizing the BMP pathway with Noggin increased the size of primordia. A threshold number of mesenchymal cells with a basal level of adhesion molecules such as NCAM were sufficient to trigger the patterning process. The process is best visualized by the progressive restriction of β-catenin transcripts in the epidermis. Therefore, feather size, number and spacing are modulated through the available morphogen ligands and receptors in the system.en_US
dc.languageengen_US
dc.publisherThe Company of Biologists Ltd. The Journal's web site is located at http://dev.biologists.orgen_US
dc.relation.ispartofDevelopmenten_US
dc.subject.meshAnimalsen_US
dc.subject.meshBody Patterningen_US
dc.subject.meshBone Morphogenetic Protein Receptorsen_US
dc.subject.meshBone Morphogenetic Proteins - Metabolismen_US
dc.subject.meshCarrier Proteinsen_US
dc.subject.meshCell Counten_US
dc.subject.meshCell Differentiationen_US
dc.subject.meshCell Sizeen_US
dc.subject.meshChick Embryoen_US
dc.subject.meshCytoskeletal Proteins - Metabolismen_US
dc.subject.meshEpithelium - Metabolismen_US
dc.subject.meshFeathers - Embryologyen_US
dc.subject.meshMesoderm - Cytology - Metabolismen_US
dc.subject.meshModels, Biologicalen_US
dc.subject.meshNeural Cell Adhesion Molecules - Metabolismen_US
dc.subject.meshProteins - Metabolismen_US
dc.subject.meshReceptors, Cell Surface - Metabolismen_US
dc.subject.meshReceptors, Growth Factoren_US
dc.subject.meshTrans-Activatorsen_US
dc.subject.meshBeta Cateninen_US
dc.titleSelf-organization of periodic patterns by dissociated feather mesenchymal cells and the regulation of size, number and spacing of primordiaen_US
dc.typeArticleen_US
dc.identifier.emailJung, HS: hsjung@yuhs.acen_US
dc.identifier.authorityJung, HS=rp01683en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid10529418-
dc.identifier.scopuseid_2-s2.0-0033456175en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0033456175&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume126en_US
dc.identifier.issue22en_US
dc.identifier.spage4997en_US
dc.identifier.epage5009en_US
dc.identifier.isiWOS:000084171700008-
dc.publisher.placeUnited Kingdomen_US
dc.identifier.scopusauthoridJiang, TX=7402148591en_US
dc.identifier.scopusauthoridJung, HS=7403030195en_US
dc.identifier.scopusauthoridWidelitz, RB=6701556360en_US
dc.identifier.scopusauthoridChuong, CM=7103159962en_US

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