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Article: Shh, Bmp-2, Bmp-4 and Fgf-8 are associated with initiation and patterning of mouse tongue papillae

TitleShh, Bmp-2, Bmp-4 and Fgf-8 are associated with initiation and patterning of mouse tongue papillae
Authors
Issue Date1999
PublisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/modo
Citation
Mechanisms Of Development, 1999, v. 81 n. 1-2, p. 179-182 How to Cite?
AbstractSpacing patterns are of fundamental importance in various repeated structures which develop at regular intervals such as feathers, teeth and insect ommatidia. The mouse tongue develops a regular papilla pattern and provides a good model to study pattern formation. We examined the expression patterns of the signalling molecules, sonic hedgehog (Shh), bone morphogenetic proteins -2 and -4 (Bmp-2 and Bmp-4), and fibroblast growth factor-8 (Fgf-8) in mouse embryos between E 10.5 and 15. We show that all four genes are expressed uniformly in the tongue epithelium between E 10.5 and 11. At E 13, before morphologically detectable gustatory papillae initiation, Shh, Bmp-2 and Bmp-4 expression segregates into discrete spots, whereas, Fgf-8 is downregulated. At E 14, small eminences in the anterior part of the tongue are the first morphological indications of fungiform papillae, and they express Shh and Bmp-2, whereas, Bmp-4 is almost absent in the tongue. We conclude that these conserved signalling molecules are associated with the initiation and early morphogenesis of the tongue papillae.
Persistent Identifierhttp://hdl.handle.net/10722/169532
ISSN
2015 Impact Factor: 2.041
2015 SCImago Journal Rankings: 1.368
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorJung, HSen_US
dc.contributor.authorOropeza, Ven_US
dc.contributor.authorThesleff, Ien_US
dc.date.accessioned2012-10-25T04:52:35Z-
dc.date.available2012-10-25T04:52:35Z-
dc.date.issued1999en_US
dc.identifier.citationMechanisms Of Development, 1999, v. 81 n. 1-2, p. 179-182en_US
dc.identifier.issn0925-4773en_US
dc.identifier.urihttp://hdl.handle.net/10722/169532-
dc.description.abstractSpacing patterns are of fundamental importance in various repeated structures which develop at regular intervals such as feathers, teeth and insect ommatidia. The mouse tongue develops a regular papilla pattern and provides a good model to study pattern formation. We examined the expression patterns of the signalling molecules, sonic hedgehog (Shh), bone morphogenetic proteins -2 and -4 (Bmp-2 and Bmp-4), and fibroblast growth factor-8 (Fgf-8) in mouse embryos between E 10.5 and 15. We show that all four genes are expressed uniformly in the tongue epithelium between E 10.5 and 11. At E 13, before morphologically detectable gustatory papillae initiation, Shh, Bmp-2 and Bmp-4 expression segregates into discrete spots, whereas, Fgf-8 is downregulated. At E 14, small eminences in the anterior part of the tongue are the first morphological indications of fungiform papillae, and they express Shh and Bmp-2, whereas, Bmp-4 is almost absent in the tongue. We conclude that these conserved signalling molecules are associated with the initiation and early morphogenesis of the tongue papillae.en_US
dc.languageengen_US
dc.publisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/modoen_US
dc.relation.ispartofMechanisms of Developmenten_US
dc.subject.meshAnimalsen_US
dc.subject.meshBone Morphogenetic Protein 2en_US
dc.subject.meshBone Morphogenetic Protein 4en_US
dc.subject.meshBone Morphogenetic Proteins - Analysis - Metabolismen_US
dc.subject.meshEosine Yellowish-(Ys) - Metabolismen_US
dc.subject.meshFibroblast Growth Factor 8en_US
dc.subject.meshFibroblast Growth Factors - Analysis - Metabolismen_US
dc.subject.meshGene Expression Regulation, Developmentalen_US
dc.subject.meshHedgehog Proteinsen_US
dc.subject.meshHematoxylin - Metabolismen_US
dc.subject.meshIn Situ Hybridizationen_US
dc.subject.meshMiceen_US
dc.subject.meshMice, Inbred Cbaen_US
dc.subject.meshMice, Inbred Strainsen_US
dc.subject.meshProteins - Analysis - Metabolismen_US
dc.subject.meshSignal Transductionen_US
dc.subject.meshTime Factorsen_US
dc.subject.meshTongue - Embryologyen_US
dc.subject.meshTrans-Activatorsen_US
dc.subject.meshTransforming Growth Factor Betaen_US
dc.titleShh, Bmp-2, Bmp-4 and Fgf-8 are associated with initiation and patterning of mouse tongue papillaeen_US
dc.typeArticleen_US
dc.identifier.emailJung, HS: hsjung@yuhs.acen_US
dc.identifier.authorityJung, HS=rp01683en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/S0925-4773(98)00234-2en_US
dc.identifier.pmid10330496-
dc.identifier.scopuseid_2-s2.0-0032962770en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0032962770&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume81en_US
dc.identifier.issue1-2en_US
dc.identifier.spage179en_US
dc.identifier.epage182en_US
dc.identifier.isiWOS:000079754600016-
dc.publisher.placeIrelanden_US
dc.identifier.scopusauthoridJung, HS=7403030195en_US
dc.identifier.scopusauthoridOropeza, V=8585569800en_US
dc.identifier.scopusauthoridThesleff, I=7005319521en_US

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