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Article: The formation of the feather pattern in chick skin after a proportion of cells have been killed by X-irradiation

TitleThe formation of the feather pattern in chick skin after a proportion of cells have been killed by X-irradiation
Authors
Issue Date1999
Citation
International Journal Of Developmental Biology, 1999, v. 43 n. 2, p. 117-123 How to Cite?
AbstractThe formation of periodic patterns is of fundamental importance in embryonic development. One of the simplest and most frequently observed patterns is the maintenance of a minimum distance between neighbouring elements, for example between teeth, hair, feathers, digits etc. Theoretical models describing these phenomena have been proposed for feather patterning. However, there has been no detailed quantitative analysis of the relationship between cell population density and feather spacing. To define the relation between these quantities and specifically to test the prediction of a mathematical model, we have examined the formation of the feather pattern after varying proportions of the dermal cells have been killed by X- irradiation. It is known that the development of a feather primordium is normally associated with an increase in cell population density in the dermis. Using X-ray irradiation of the skin in vivo and in vitro, we show that the relation between cell population density and spacing of feather primordia indicates the importance of a threshold number of cells for feather patterning. Moreover, there is a prima facie case for supposing that X-rays act on feather spacing system, reducing the ability of dermal cells to prevent spreading of the pattern. Thus, X-irradiation may have a secondary effect on the spacing of primordia rather than, or as well as, affecting the mechanisms that determine their primary positions.
Persistent Identifierhttp://hdl.handle.net/10722/169531
ISSN
2015 Impact Factor: 1.753
2015 SCImago Journal Rankings: 1.087
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorJung, HSen_US
dc.contributor.authorWolpert, Len_US
dc.contributor.authorDavidson, Den_US
dc.date.accessioned2012-10-25T04:52:35Z-
dc.date.available2012-10-25T04:52:35Z-
dc.date.issued1999en_US
dc.identifier.citationInternational Journal Of Developmental Biology, 1999, v. 43 n. 2, p. 117-123en_US
dc.identifier.issn0214-6282en_US
dc.identifier.urihttp://hdl.handle.net/10722/169531-
dc.description.abstractThe formation of periodic patterns is of fundamental importance in embryonic development. One of the simplest and most frequently observed patterns is the maintenance of a minimum distance between neighbouring elements, for example between teeth, hair, feathers, digits etc. Theoretical models describing these phenomena have been proposed for feather patterning. However, there has been no detailed quantitative analysis of the relationship between cell population density and feather spacing. To define the relation between these quantities and specifically to test the prediction of a mathematical model, we have examined the formation of the feather pattern after varying proportions of the dermal cells have been killed by X- irradiation. It is known that the development of a feather primordium is normally associated with an increase in cell population density in the dermis. Using X-ray irradiation of the skin in vivo and in vitro, we show that the relation between cell population density and spacing of feather primordia indicates the importance of a threshold number of cells for feather patterning. Moreover, there is a prima facie case for supposing that X-rays act on feather spacing system, reducing the ability of dermal cells to prevent spreading of the pattern. Thus, X-irradiation may have a secondary effect on the spacing of primordia rather than, or as well as, affecting the mechanisms that determine their primary positions.en_US
dc.languageengen_US
dc.relation.ispartofInternational Journal of Developmental Biologyen_US
dc.subject.meshAnimalsen_US
dc.subject.meshBody Patterningen_US
dc.subject.meshCell Deathen_US
dc.subject.meshCell Divisionen_US
dc.subject.meshCell Lineageen_US
dc.subject.meshChick Embryoen_US
dc.subject.meshDose-Response Relationship, Radiationen_US
dc.subject.meshEpidermis - Embryology - Radiation Effectsen_US
dc.subject.meshMathematicsen_US
dc.subject.meshModels, Biologicalen_US
dc.subject.meshOrgan Culture Techniquesen_US
dc.titleThe formation of the feather pattern in chick skin after a proportion of cells have been killed by X-irradiationen_US
dc.typeArticleen_US
dc.identifier.emailJung, HS: hsjung@yuhs.acen_US
dc.identifier.authorityJung, HS=rp01683en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid10235387-
dc.identifier.scopuseid_2-s2.0-0032960374en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0032960374&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume43en_US
dc.identifier.issue2en_US
dc.identifier.spage117en_US
dc.identifier.epage123en_US
dc.identifier.isiWOS:000079444200003-
dc.identifier.scopusauthoridJung, HS=7403030195en_US
dc.identifier.scopusauthoridWolpert, L=7005114065en_US
dc.identifier.scopusauthoridDavidson, D=7402300237en_US

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