File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Lineage and pluripotentiality of epithelial precursor cells in developing chicken skin

TitleLineage and pluripotentiality of epithelial precursor cells in developing chicken skin
Authors
Issue Date1998
PublisherN R C Research Press. The Journal's web site is located at http://pubs.nrc-cnrc.gc.ca/cgi-bin/rp/rp2_desc_e?bcb
Citation
Biochemistry And Cell Biology, 1998, v. 76 n. 6, p. 1069-1077 How to Cite?
AbstractHow do epithelial cells in developing skin accommodate the constantly growing embryo? Where do cells in skin appendages come from? Are they derivatives of a single appendage stem cell, or are they polyclonal? Here we analyze these issues in developing chicken skin using a replication-defective virus carrying β-galactosidase and DiI microinjections. The results demonstrate that in early skin, epithelial cells labelled near the spine show a parallel linear stripe distribution pattern that is perpendicular to the midline of the trunk. This is similar to the human lines of Blaschko, a linear pattern on the skin, which many skin nevoid or acquired disorders follow. In later skin, feather buds form and contain a mixture of labeled and unlabeled cells, attesting to their polyclonal origin. When cells are traced for shorter time intervals, the labeled progeny appear to follow certain rules. The degree of cell dispersion and mixing increases with a longer incubation period between the time of labeling and detection. The spatial maturation sequence of skin appendages is not regulated by the order in which epithelial cells are generated. Epithelial cells at this developmental stage are pluripotent and competent to respond to new signals to assume appropriate fates according to their micro-environment. The results suggest that local interactions act upon the originally linearly deposited pluripotential epithelial cells to form skin appendages.
Persistent Identifierhttp://hdl.handle.net/10722/169529
ISSN
2015 Impact Factor: 1.527
2015 SCImago Journal Rankings: 0.859
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorChuong, CMen_US
dc.contributor.authorJung, HSen_US
dc.contributor.authorNoden, Den_US
dc.contributor.authorWidelitz, RBen_US
dc.date.accessioned2012-10-25T04:52:34Z-
dc.date.available2012-10-25T04:52:34Z-
dc.date.issued1998en_US
dc.identifier.citationBiochemistry And Cell Biology, 1998, v. 76 n. 6, p. 1069-1077en_US
dc.identifier.issn0829-8211en_US
dc.identifier.urihttp://hdl.handle.net/10722/169529-
dc.description.abstractHow do epithelial cells in developing skin accommodate the constantly growing embryo? Where do cells in skin appendages come from? Are they derivatives of a single appendage stem cell, or are they polyclonal? Here we analyze these issues in developing chicken skin using a replication-defective virus carrying β-galactosidase and DiI microinjections. The results demonstrate that in early skin, epithelial cells labelled near the spine show a parallel linear stripe distribution pattern that is perpendicular to the midline of the trunk. This is similar to the human lines of Blaschko, a linear pattern on the skin, which many skin nevoid or acquired disorders follow. In later skin, feather buds form and contain a mixture of labeled and unlabeled cells, attesting to their polyclonal origin. When cells are traced for shorter time intervals, the labeled progeny appear to follow certain rules. The degree of cell dispersion and mixing increases with a longer incubation period between the time of labeling and detection. The spatial maturation sequence of skin appendages is not regulated by the order in which epithelial cells are generated. Epithelial cells at this developmental stage are pluripotent and competent to respond to new signals to assume appropriate fates according to their micro-environment. The results suggest that local interactions act upon the originally linearly deposited pluripotential epithelial cells to form skin appendages.en_US
dc.languageengen_US
dc.publisherN R C Research Press. The Journal's web site is located at http://pubs.nrc-cnrc.gc.ca/cgi-bin/rp/rp2_desc_e?bcben_US
dc.relation.ispartofBiochemistry and Cell Biologyen_US
dc.subject.meshAnimalsen_US
dc.subject.meshCell Differentiationen_US
dc.subject.meshCell Lineageen_US
dc.subject.meshChick Embryoen_US
dc.subject.meshEpithelial Cellsen_US
dc.subject.meshFeathers - Embryology - Metabolismen_US
dc.subject.meshHair - Embryology - Metabolismen_US
dc.subject.meshIn Situ Hybridizationen_US
dc.subject.meshModels, Biologicalen_US
dc.subject.meshSkin - Embryologyen_US
dc.subject.meshStem Cells - Physiologyen_US
dc.subject.meshTime Factorsen_US
dc.subject.meshTissue Distributionen_US
dc.titleLineage and pluripotentiality of epithelial precursor cells in developing chicken skinen_US
dc.typeArticleen_US
dc.identifier.emailJung, HS: hsjung@yuhs.acen_US
dc.identifier.authorityJung, HS=rp01683en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1139/bcb-76-6-1069en_US
dc.identifier.pmid10392717-
dc.identifier.scopuseid_2-s2.0-0032322007en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0032322007&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume76en_US
dc.identifier.issue6en_US
dc.identifier.spage1069en_US
dc.identifier.epage1077en_US
dc.identifier.isiWOS:000080844900015-
dc.publisher.placeCanadaen_US
dc.identifier.scopusauthoridChuong, CM=7103159962en_US
dc.identifier.scopusauthoridJung, HS=7403030195en_US
dc.identifier.scopusauthoridNoden, D=7003465811en_US
dc.identifier.scopusauthoridWidelitz, RB=6701556360en_US

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats