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Article: Molecular histology in skin appendage morphogenesis

TitleMolecular histology in skin appendage morphogenesis
Authors
Issue Date1997
PublisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www.interscience.wiley.com/jpages/1059-910X/
Citation
Microscopy Research And Technique, 1997, v. 38 n. 4, p. 452-465 How to Cite?
AbstractClassical histological studies have demonstrated the cellular organization of skin appendages and helped us appreciate the intricate structures and function of skin appendages. At this juncture, questions can be directed to determine how these cellular organizations are achieved. How do cells rearrange themselves to form the complex cyto-architecture of skin appendages? What are the molecular bases of the morphogenesis and histogenesis of skin appendages? Recently, many new molecules expressed in a spatial and temporal specific manner during the formation of skin appendages were identified by molecular biological approaches. In this review, novel molecular techniques that are useful in skin appendage research are discussed. The distribution of exemplary molecules from different categories including growth factors, intracellular signaling molecules, homeobox genes, adhesion molecules, and extracellular matrix molecules are summarized in a diagram using feather and hair as models. We hope that these results will serve as the ground work for completing the molecular mapping of skin appendages which will refine and re-define our understanding of the developmental process beyond relying on morphological criteria. We also hope that the listed protocols will help those who are interested in this venture. This new molecular histology of skin appendages is the foundation for forming new hypotheses on how molecules are mechanistically involved in skin appendage development and for designing experiments to test them. This may also lead to the modulation of healing and regeneration processes in future treatment modalities.
Persistent Identifierhttp://hdl.handle.net/10722/169527
ISSN
2015 Impact Factor: 1.13
2015 SCImago Journal Rankings: 0.456
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorWidelitz, RBen_US
dc.contributor.authorJiang, TXen_US
dc.contributor.authorNoveen, Aen_US
dc.contributor.authorTingBerreth, SAen_US
dc.contributor.authorYin, Een_US
dc.contributor.authorJung, HSen_US
dc.contributor.authorChuong, CMen_US
dc.date.accessioned2012-10-25T04:52:33Z-
dc.date.available2012-10-25T04:52:33Z-
dc.date.issued1997en_US
dc.identifier.citationMicroscopy Research And Technique, 1997, v. 38 n. 4, p. 452-465en_US
dc.identifier.issn1059-910Xen_US
dc.identifier.urihttp://hdl.handle.net/10722/169527-
dc.description.abstractClassical histological studies have demonstrated the cellular organization of skin appendages and helped us appreciate the intricate structures and function of skin appendages. At this juncture, questions can be directed to determine how these cellular organizations are achieved. How do cells rearrange themselves to form the complex cyto-architecture of skin appendages? What are the molecular bases of the morphogenesis and histogenesis of skin appendages? Recently, many new molecules expressed in a spatial and temporal specific manner during the formation of skin appendages were identified by molecular biological approaches. In this review, novel molecular techniques that are useful in skin appendage research are discussed. The distribution of exemplary molecules from different categories including growth factors, intracellular signaling molecules, homeobox genes, adhesion molecules, and extracellular matrix molecules are summarized in a diagram using feather and hair as models. We hope that these results will serve as the ground work for completing the molecular mapping of skin appendages which will refine and re-define our understanding of the developmental process beyond relying on morphological criteria. We also hope that the listed protocols will help those who are interested in this venture. This new molecular histology of skin appendages is the foundation for forming new hypotheses on how molecules are mechanistically involved in skin appendage development and for designing experiments to test them. This may also lead to the modulation of healing and regeneration processes in future treatment modalities.en_US
dc.languageengen_US
dc.publisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www.interscience.wiley.com/jpages/1059-910X/en_US
dc.relation.ispartofMicroscopy Research and Techniqueen_US
dc.subject.meshAnimalsen_US
dc.subject.meshApoptosisen_US
dc.subject.meshChickensen_US
dc.subject.meshFeathers - Cytology - Growth & Development - Metabolismen_US
dc.subject.meshGene Expression Regulation, Developmentalen_US
dc.subject.meshGrowth Substances - Genetics - Metabolismen_US
dc.subject.meshHair - Cytology - Growth & Development - Metabolismen_US
dc.subject.meshMiceen_US
dc.subject.meshModels, Biologicalen_US
dc.subject.meshRna, Messenger - Metabolismen_US
dc.subject.meshSignal Transductionen_US
dc.subject.meshSkin - Cytology - Growth & Development - Metabolismen_US
dc.titleMolecular histology in skin appendage morphogenesisen_US
dc.typeArticleen_US
dc.identifier.emailJung, HS: hsjung@yuhs.acen_US
dc.identifier.authorityJung, HS=rp01683en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1002/(SICI)1097-0029(19970815)38:4<452::AID-JEMT13>3.0.CO;2-Ien_US
dc.identifier.pmid9297695-
dc.identifier.scopuseid_2-s2.0-0030862928en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0030862928&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume38en_US
dc.identifier.issue4en_US
dc.identifier.spage452en_US
dc.identifier.epage465en_US
dc.identifier.isiWOS:A1997XU93000013-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridWidelitz, RB=6701556360en_US
dc.identifier.scopusauthoridJiang, TX=7402148591en_US
dc.identifier.scopusauthoridNoveen, A=6602604754en_US
dc.identifier.scopusauthoridTingBerreth, SA=6506000954en_US
dc.identifier.scopusauthoridYin, E=7004049908en_US
dc.identifier.scopusauthoridJung, HS=7403030195en_US
dc.identifier.scopusauthoridChuong, CM=7103159962en_US

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