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Article: Postablation stimulated thyroglobulin level is an important predictor of biochemical complete remission after reoperative cervical neck dissection in persistent/recurrent papillary thyroid carcinoma

TitlePostablation stimulated thyroglobulin level is an important predictor of biochemical complete remission after reoperative cervical neck dissection in persistent/recurrent papillary thyroid carcinoma
Authors
Issue Date2013
PublisherSpringer New York LLC. The Journal's web site is located at http://www.annalssurgicaloncology.org
Citation
Annals of Surgical Oncology, 2013, v. 20 n. 2, p. 653-659 How to Cite?
AbstractBACKGROUND: The efficacy of reoperative cervical neck dissection (RND) in achieving biochemical complete remission (BCR) (or postreoperation stimulated thyroglobulin [sTg] of <0.5 ng/mL) remains unclear in persistent/recurrent papillary thyroid carcinoma (PTC). We hypothesized that lower postablation sTg levels would indicate a higher rate of BCR after RND. Our study examined the association between postablation sTg and BCR after one or more RNDs. METHODS: Of 199 patients who underwent RND, 81 patients were eligible. The postablation sTg levels (2 ng/mL) were correlated with the postreoperation sTg levels after RNDs. Patients' clinicopathological characteristics, operative findings, and subsequent RNDs were compared between those with BCR after RNDs and those without. RESULTS: Those with postablation sTg levels of 2 ng/mL. Overall BCR gradually decreased after each subsequent RND. Postablation sTg significantly correlated with postreoperation sTg (rho = 0.509, p < 0.001). After adjusting for the number of metastatic lymph nodes excised at first RND and presence of extranodal extension, postablation sTg of
Persistent Identifierhttp://hdl.handle.net/10722/169274
ISSN
2015 Impact Factor: 3.655
2015 SCImago Journal Rankings: 1.902
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorLang, BHHen_US
dc.contributor.authorWong, KPen_US
dc.contributor.authorWan, KYen_US
dc.date.accessioned2012-10-18T08:48:15Z-
dc.date.available2012-10-18T08:48:15Z-
dc.date.issued2013en_US
dc.identifier.citationAnnals of Surgical Oncology, 2013, v. 20 n. 2, p. 653-659en_US
dc.identifier.issn1068-9265-
dc.identifier.urihttp://hdl.handle.net/10722/169274-
dc.description.abstractBACKGROUND: The efficacy of reoperative cervical neck dissection (RND) in achieving biochemical complete remission (BCR) (or postreoperation stimulated thyroglobulin [sTg] of <0.5 ng/mL) remains unclear in persistent/recurrent papillary thyroid carcinoma (PTC). We hypothesized that lower postablation sTg levels would indicate a higher rate of BCR after RND. Our study examined the association between postablation sTg and BCR after one or more RNDs. METHODS: Of 199 patients who underwent RND, 81 patients were eligible. The postablation sTg levels (</=2 and >2 ng/mL) were correlated with the postreoperation sTg levels after RNDs. Patients' clinicopathological characteristics, operative findings, and subsequent RNDs were compared between those with BCR after RNDs and those without. RESULTS: Those with postablation sTg levels of </=2 ng/mL had significantly higher BCR rate after the first RND (77.8 vs. 5.6 %, p < 0.001), overall BCR after one or more RNDs (77.8 vs. 9.3 %, p < 0.001), and better 5-year recurrence-free survival after the first RND (80.0 vs. 60.1 %, p = 0.049) than those with postablation sTg levels of >2 ng/mL. Overall BCR gradually decreased after each subsequent RND. Postablation sTg significantly correlated with postreoperation sTg (rho = 0.509, p < 0.001). After adjusting for the number of metastatic lymph nodes excised at first RND and presence of extranodal extension, postablation sTg of </= 0.2 ng/mL was the only independent factor for BCR after one or more RNDs (odds ratio 37.0, 95 % confidence interval 5.68-250.0, p = 0.001). CONCLUSIONS: Only a third of patients who underwent one or more RNDs for persistent/recurrent PTC had BCR afterward. Postablation sTg level was an independent factor for BCR. Completeness of the initial operation is important for the subsequent success of RND.-
dc.languageengen_US
dc.publisherSpringer New York LLC. The Journal's web site is located at http://www.annalssurgicaloncology.org-
dc.relation.ispartofAnnals of Surgical Oncologyen_US
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.titlePostablation stimulated thyroglobulin level is an important predictor of biochemical complete remission after reoperative cervical neck dissection in persistent/recurrent papillary thyroid carcinomaen_US
dc.typeArticleen_US
dc.identifier.emailLang, BHH: blang@hkucc.hku.hken_US
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.1245/s10434-012-2624-8-
dc.identifier.pmid22956067-
dc.identifier.scopuseid_2-s2.0-84878825962-
dc.identifier.hkuros212061en_US
dc.identifier.isiWOS:000314291100042-
dc.publisher.placeUnited States-
dc.identifier.citeulike11229943-

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