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Article: Cancer stem cell as a potential therapeutic target in hepatocellular carcinoma

TitleCancer stem cell as a potential therapeutic target in hepatocellular carcinoma
Authors
KeywordsCancer stem cells
Hepatocellular carcinoma
Molecular signaling pathways
Targeted therapy
Multidrug resistance 1
Issue Date2012
PublisherBentham Science Publishers Ltd. The Journal's web site is located at http://www.bentham.org/ccdt/index.htm
Citation
Current Cancer Drug Targets, 2012, v. 12 n. 9, p. 1081-1094 How to Cite?
AbstractHepatocellular carcinoma (HCC) is one of the most common human cancers. HCC is a chemoresistant cancer and the current drug therapy has limited efficacy. As a result, the prognosis of HCC patients is generally poor. Recent studies have demonstrated that a subpopulation of cancer cells with stem cell properties, called cancer stem cells (CSCs), are responsible for growth and metastasis of cancer. CSCs characterized by several markers including CD133, CD44, CD90, OV6, Epithelial cell adhesion molecule (EpCAM) and CD13 have been isolated from different human HCC cell lines or specimens. CSCs share many of the signaling pathways found in normal stem cells, such as Wnt, Hedgehog, Notch and Transforming growth factor-beta (TGF-beta) pathways. These pathways are involved in self-renewal, differentiation and survival of CSCs. There is evidence of deregulation of these pathways in HCC CSCs. MicroRNAs also play an important role in regulating signaling pathways in HCC, and recent data suggested an important role of microRNA in CSCs of HCC. Therapeutic targeting of CSCs may provide a novel strategy that is more effective than the current drugs targeting the bulk mature cancer cells in treatment of HCC.
Persistent Identifierhttp://hdl.handle.net/10722/169269
ISSN
2015 Impact Factor: 3.707
2015 SCImago Journal Rankings: 1.537

 

DC FieldValueLanguage
dc.contributor.authorPang, RWCen_US
dc.contributor.authorPoon, RTPen_US
dc.date.accessioned2012-10-18T08:48:11Z-
dc.date.available2012-10-18T08:48:11Z-
dc.date.issued2012en_US
dc.identifier.citationCurrent Cancer Drug Targets, 2012, v. 12 n. 9, p. 1081-1094en_US
dc.identifier.issn1568-0096-
dc.identifier.urihttp://hdl.handle.net/10722/169269-
dc.description.abstractHepatocellular carcinoma (HCC) is one of the most common human cancers. HCC is a chemoresistant cancer and the current drug therapy has limited efficacy. As a result, the prognosis of HCC patients is generally poor. Recent studies have demonstrated that a subpopulation of cancer cells with stem cell properties, called cancer stem cells (CSCs), are responsible for growth and metastasis of cancer. CSCs characterized by several markers including CD133, CD44, CD90, OV6, Epithelial cell adhesion molecule (EpCAM) and CD13 have been isolated from different human HCC cell lines or specimens. CSCs share many of the signaling pathways found in normal stem cells, such as Wnt, Hedgehog, Notch and Transforming growth factor-beta (TGF-beta) pathways. These pathways are involved in self-renewal, differentiation and survival of CSCs. There is evidence of deregulation of these pathways in HCC CSCs. MicroRNAs also play an important role in regulating signaling pathways in HCC, and recent data suggested an important role of microRNA in CSCs of HCC. Therapeutic targeting of CSCs may provide a novel strategy that is more effective than the current drugs targeting the bulk mature cancer cells in treatment of HCC.-
dc.languageengen_US
dc.publisherBentham Science Publishers Ltd. The Journal's web site is located at http://www.bentham.org/ccdt/index.htm-
dc.relation.ispartofCurrent Cancer Drug Targetsen_US
dc.subjectCancer stem cells-
dc.subjectHepatocellular carcinoma-
dc.subjectMolecular signaling pathways-
dc.subjectTargeted therapy-
dc.subjectMultidrug resistance 1-
dc.titleCancer stem cell as a potential therapeutic target in hepatocellular carcinomaen_US
dc.typeArticleen_US
dc.identifier.emailPang, RWC: robertap@hku.hken_US
dc.identifier.emailPoon, RTP: poontp@hku.hken_US
dc.identifier.authorityPang, RWC=rp00274en_US
dc.identifier.authorityPoon, RTP=rp00446en_US
dc.identifier.doi10.2174/15680096112091081-
dc.identifier.pmid22873219-
dc.identifier.scopuseid_2-s2.0-84872572939-
dc.identifier.hkuros211511en_US
dc.identifier.volume12en_US
dc.identifier.issue9-
dc.identifier.spage1081-
dc.identifier.epage1094-
dc.publisher.placeNetherlands-

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