File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Induced pluripotent stem cells as a disease model for studying inherited arrhythmias: promises and hurdles

TitleInduced pluripotent stem cells as a disease model for studying inherited arrhythmias: promises and hurdles
Authors
Issue Date2012
PublisherElsevier Ltd, Trends Journals. The Journal's web site is located at http://www.elsevier.com/locate/ddmod
Citation
Drug Discovery Today: Disease Models, 2012, v. 9 n. 4, p. e199-e207 How to Cite?
AbstractCardiac ion channel mutations can lead to alterations of action potential and/or conduction properties, and consequently, arrhythmias. Although sudden cardiac death is a common manifestation of inherited arrhythmias, many aspects of the underlying mechanisms remain undefined. In addition to their potential for cell-based therapies, patient-specific induced pluripotent stem cells (iPSCs) also offer an expandable source of human cardiomyocytes for disease modeling, high-throughput drug screening and cardiotoxicity testing. Here, we review current efforts of using iPSC to model monogenetic arrhythmic diseases and discuss the associated challenges.
Persistent Identifierhttp://hdl.handle.net/10722/169250
ISSN
2015 SCImago Journal Rankings: 0.286

 

DC FieldValueLanguage
dc.contributor.authorLui, KOen_US
dc.contributor.authorStachel, MW-
dc.contributor.authorLieu, DK-
dc.contributor.authorLi, RA-
dc.contributor.authorBu, L-
dc.date.accessioned2012-10-18T08:47:07Z-
dc.date.available2012-10-18T08:47:07Z-
dc.date.issued2012en_US
dc.identifier.citationDrug Discovery Today: Disease Models, 2012, v. 9 n. 4, p. e199-e207en_US
dc.identifier.issn1740-6757-
dc.identifier.urihttp://hdl.handle.net/10722/169250-
dc.description.abstractCardiac ion channel mutations can lead to alterations of action potential and/or conduction properties, and consequently, arrhythmias. Although sudden cardiac death is a common manifestation of inherited arrhythmias, many aspects of the underlying mechanisms remain undefined. In addition to their potential for cell-based therapies, patient-specific induced pluripotent stem cells (iPSCs) also offer an expandable source of human cardiomyocytes for disease modeling, high-throughput drug screening and cardiotoxicity testing. Here, we review current efforts of using iPSC to model monogenetic arrhythmic diseases and discuss the associated challenges.-
dc.languageengen_US
dc.publisherElsevier Ltd, Trends Journals. The Journal's web site is located at http://www.elsevier.com/locate/ddmod-
dc.relation.ispartofDrug Discovery Today: Disease Modelsen_US
dc.titleInduced pluripotent stem cells as a disease model for studying inherited arrhythmias: promises and hurdlesen_US
dc.typeArticleen_US
dc.identifier.emailLi, RA: ronaldli@hkucc.hku.hken_US
dc.identifier.authorityLi, RA=rp01352en_US
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.ddmod.2012.09.001-
dc.identifier.scopuseid_2-s2.0-84876694169-
dc.identifier.hkuros212194en_US
dc.identifier.hkuros197127-
dc.identifier.hkuros219960-
dc.identifier.volume9-
dc.identifier.issue4-
dc.identifier.spagee199-
dc.identifier.epagee207-
dc.publisher.placeUnited Kingdom-

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats