File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Human pluripotent stem cell-derived cardiovascular progenitors for heart regeneration

TitleHuman pluripotent stem cell-derived cardiovascular progenitors for heart regeneration
Authors
Issue Date2012
PublisherElsevier Ltd, Trends Journals. The Journal's web site is located at http://www.elsevier.com/locate/ddmod
Citation
Drug Discovery Today: Disease Models, 2012, v. 9 n. 4, p. e189-e197 How to Cite?
AbstractDuring normal development, cardiac progenitor cells (CPCs) in the pharyngeal mesoderm migrate and contribute to formation of the heart tube. Characterization of the signals that maintain, expand and regulate migration and differentiation of CPCs is essential for understanding the etiology of congenital heart diseases and the potential to differentiate pluripotent stem cells (PSCs) into CPCs for cardiac repair. Although the intricate mechanisms of cardiogenesis are being gradually unraveled, recent clinical and preclinical research studies underscore that full restoration of myocardial structure and function following pathological injuries or aging remains a daunting challenge. Here, we discuss the innate capacity for cardiac regeneration in zebrafish, the types of progenitors driving development in the mammalian heart and how to empower CPCs or myocytes derived from human PSCs to survive, engraft and improve function in the hostile microenvironment of the post-ischemic heart. © 2012 Elsevier Ltd. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/169249
ISSN
2015 SCImago Journal Rankings: 0.286

 

DC FieldValueLanguage
dc.contributor.authorLui, KOen_US
dc.contributor.authorStachel, MWen_US
dc.contributor.authorLi, RAen_US
dc.contributor.authorBu, L-
dc.date.accessioned2012-10-18T08:47:07Z-
dc.date.available2012-10-18T08:47:07Z-
dc.date.issued2012en_US
dc.identifier.citationDrug Discovery Today: Disease Models, 2012, v. 9 n. 4, p. e189-e197en_US
dc.identifier.issn1740-6757-
dc.identifier.urihttp://hdl.handle.net/10722/169249-
dc.description.abstractDuring normal development, cardiac progenitor cells (CPCs) in the pharyngeal mesoderm migrate and contribute to formation of the heart tube. Characterization of the signals that maintain, expand and regulate migration and differentiation of CPCs is essential for understanding the etiology of congenital heart diseases and the potential to differentiate pluripotent stem cells (PSCs) into CPCs for cardiac repair. Although the intricate mechanisms of cardiogenesis are being gradually unraveled, recent clinical and preclinical research studies underscore that full restoration of myocardial structure and function following pathological injuries or aging remains a daunting challenge. Here, we discuss the innate capacity for cardiac regeneration in zebrafish, the types of progenitors driving development in the mammalian heart and how to empower CPCs or myocytes derived from human PSCs to survive, engraft and improve function in the hostile microenvironment of the post-ischemic heart. © 2012 Elsevier Ltd. All rights reserved.-
dc.languageengen_US
dc.publisherElsevier Ltd, Trends Journals. The Journal's web site is located at http://www.elsevier.com/locate/ddmod-
dc.relation.ispartofDrug Discovery Today: Disease Modelsen_US
dc.titleHuman pluripotent stem cell-derived cardiovascular progenitors for heart regenerationen_US
dc.typeArticleen_US
dc.identifier.emailLui, KO: kolui@hku.hken_US
dc.identifier.emailLi, RA: ronaldli@hkucc.hku.hken_US
dc.identifier.emailBu, L: leibu@hku.hken_US
dc.identifier.authorityLi, RA=rp01352en_US
dc.identifier.authorityBu, L=rp01534en_US
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.ddmod.2012.08.003-
dc.identifier.scopuseid_2-s2.0-84876690410-
dc.identifier.hkuros212193en_US
dc.identifier.hkuros219952-
dc.publisher.placeUnited Kingdom-

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats