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Article: Unraveling the resistance of microbial biofilms: Has proteomics been helpful?

TitleUnraveling the resistance of microbial biofilms: Has proteomics been helpful?
Authors
KeywordsBiofilm
Microbiology
Resistance
Issue Date2012
PublisherWiley - V C H Verlag GmbH & Co KGaA. The Journal's web site is located at http://www.wiley-vch.de/home/proteomics
Citation
Proteomics, 2012, v. 12 n. 4-5, p. 651-665 How to Cite?
AbstractBiofilms are surface-attached, matrix-encased, structured microbial communities which display phenotypic features that are dramatically different from those of their free-floating, or planktonic, counterparts. Biofilms seem to be the preferred mode of growth of microorganisms in nature, and at least 65% of all human infections are associated with biofilms. The most notable and clinically relevant property of biofilms is their greater resistance to antimicrobials compared with their planktonic counterparts. Although both bacterial and fungal biofilms display this phenotypic feature, the exact mechanisms underlying their increased drug resistance are yet to be determined. Advances in proteomics techniques during the past decade have facilitated in-depth analysis of the possible mechanisms underpinning increased drug resistance in biofilms. These studies have demonstrated the ability of proteomics techniques to unravel new targets for combating microbial biofilms. In this review, we discuss the putative drug resistance mechanisms of microbial biofilms that have been uncovered by proteomics and critically evaluate the possible contribution of the new knowledge to future development in the field. We also summarize strategic uses of novel proteomics technologies in studies related to drug resistance mechanisms of microbial biofilms.
Persistent Identifierhttp://hdl.handle.net/10722/169163
ISSN
2015 Impact Factor: 4.079
2015 SCImago Journal Rankings: 1.476
ISI Accession Number ID
Funding AgencyGrant Number
HKU200907176121
20080717617
Funding Information:

The authors thank Dr. Trevor Lane for editorial assistance. Mixed species biofilm image was obtained by courtesy of Dr. C. H. Chu and Dr. M. Lei. This work was supported by HKU funding 200907176121 for C. J. S. and 20080717617 for L. P. S.

References

 

DC FieldValueLanguage
dc.contributor.authorSeneviratne, CJen_US
dc.contributor.authorWang, Yen_US
dc.contributor.authorJin, Len_US
dc.contributor.authorWong, SSWen_US
dc.contributor.authorHerath, MTDKHen_US
dc.contributor.authorSamaranayake, LPen_US
dc.date.accessioned2012-10-18T08:44:53Z-
dc.date.available2012-10-18T08:44:53Z-
dc.date.issued2012en_US
dc.identifier.citationProteomics, 2012, v. 12 n. 4-5, p. 651-665en_US
dc.identifier.issn1615-9853-
dc.identifier.urihttp://hdl.handle.net/10722/169163-
dc.description.abstractBiofilms are surface-attached, matrix-encased, structured microbial communities which display phenotypic features that are dramatically different from those of their free-floating, or planktonic, counterparts. Biofilms seem to be the preferred mode of growth of microorganisms in nature, and at least 65% of all human infections are associated with biofilms. The most notable and clinically relevant property of biofilms is their greater resistance to antimicrobials compared with their planktonic counterparts. Although both bacterial and fungal biofilms display this phenotypic feature, the exact mechanisms underlying their increased drug resistance are yet to be determined. Advances in proteomics techniques during the past decade have facilitated in-depth analysis of the possible mechanisms underpinning increased drug resistance in biofilms. These studies have demonstrated the ability of proteomics techniques to unravel new targets for combating microbial biofilms. In this review, we discuss the putative drug resistance mechanisms of microbial biofilms that have been uncovered by proteomics and critically evaluate the possible contribution of the new knowledge to future development in the field. We also summarize strategic uses of novel proteomics technologies in studies related to drug resistance mechanisms of microbial biofilms.-
dc.languageengen_US
dc.publisherWiley - V C H Verlag GmbH & Co KGaA. The Journal's web site is located at http://www.wiley-vch.de/home/proteomics-
dc.relation.ispartofProteomicsen_US
dc.rightsPreprint This is the pre-peer reviewed version of the following article: Proteomics, 2012, v. 12 n. 4-5, p. 651-665, which has been published in final form at http://dx.doi.org/10.1002/pmic.201100356-
dc.subjectBiofilm-
dc.subjectMicrobiology-
dc.subjectResistance-
dc.subject.meshBacteria - drug effects-
dc.subject.meshBiofilms - drug effects - growth and development-
dc.subject.meshDrug Resistance, Fungal-
dc.subject.meshDrug Resistance, Multiple, Bacterial-
dc.subject.meshFungi - drug effects - physiology-
dc.titleUnraveling the resistance of microbial biofilms: Has proteomics been helpful?en_US
dc.typeArticleen_US
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1615-9853&volume=12&issue=4-5&spage=651&epage=665&date=2012&atitle=Unraveling+the+resistance+of+microbial+biofilms:+Has+proteomics+been+helpful?-
dc.identifier.emailSeneviratne, CJ: jaya@hku.hken_US
dc.identifier.emailWang, Y: yuwanghk@hku.hken_US
dc.identifier.emailJin, L: ljjin@hkucc.hku.hken_US
dc.identifier.emailWong, SSW: h0616549@hku.hken_US
dc.identifier.emailSamaranayake, LP: lakshman@hku.hken_US
dc.identifier.authoritySeneviratne, CJ=rp01372en_US
dc.identifier.authorityWang, Y=rp00239en_US
dc.identifier.authorityJin, L=rp00028en_US
dc.identifier.authoritySamaranayake, LP=rp00023en_US
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1002/pmic.201100356-
dc.identifier.pmid22246638-
dc.identifier.scopuseid_2-s2.0-84859240206-
dc.identifier.hkuros211984en_US
dc.identifier.hkuros204602-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-84859240206&selection=ref&src=s&origin=recordpage-
dc.identifier.volume12en_US
dc.identifier.issue4-5-
dc.identifier.spage651en_US
dc.identifier.epage665en_US
dc.identifier.eissn1615-9861-
dc.identifier.isiWOS:000302151800013-
dc.identifier.scopusauthoridSeneviratne, CJ=55161876500-
dc.identifier.scopusauthoridWang, Y=55164276500-
dc.identifier.scopusauthoridJin, L=7403328850-
dc.identifier.scopusauthoridWong, SSW=55162862100-
dc.identifier.scopusauthoridHerath, TDK=40561255100-
dc.identifier.scopusauthoridSamaranayake, LP=55164536100-

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