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Article: Neural activities during affective processing in people with Alzheimer's disease

TitleNeural activities during affective processing in people with Alzheimer's disease
Authors
KeywordsAlzheimer's Disease
Dementia
Emotional Facial Expressions
Mirror Neuron System
Issue Date2013
PublisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/neuaging
Citation
Neurobiology Of Aging, 2013, v. 34 n. 3, p. 706-715 How to Cite?
AbstractThis study examined brain activities in people with Alzheimer's disease when viewing happy, sad, and fearful facial expressions of others. A functional magnetic resonance imaging and a voxel-based morphometry methodology together with a passive viewing of emotional faces paradigm were employed to compare the affective processing in 12 people with mild Alzheimer's disease and 12 matched controls. The main finding was that the clinical participants showed reduced activations in regions associated with the motor simulation system (the ventral premotor cortex) and in regions associated with emotional simulation-empathy (the anterior insula and adjacent frontal operculum). This regional decline in blood oxygen level-dependent signals appeared to be lateralized in the left hemisphere and was not related to any structural degeneration in the clinical participants. Furthermore, the regions that showed changes in neural activity differed for the 3 emotional facial expressions studied. Findings of our study indicate that neural changes in regions associated with the motor and emotional simulation systems might play an important role in the development of Alzheimer's disease. © 2012 Elsevier Inc. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/169109
ISSN
2015 Impact Factor: 5.153
2015 SCImago Journal Rankings: 2.613
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorLee, TMCen_US
dc.contributor.authorSun, Den_US
dc.contributor.authorLeung, MKen_US
dc.contributor.authorChu, LWen_US
dc.contributor.authorKeysers, Cen_US
dc.date.accessioned2012-10-08T03:41:54Z-
dc.date.available2012-10-08T03:41:54Z-
dc.date.issued2013en_US
dc.identifier.citationNeurobiology Of Aging, 2013, v. 34 n. 3, p. 706-715en_US
dc.identifier.issn0197-4580en_US
dc.identifier.urihttp://hdl.handle.net/10722/169109-
dc.description.abstractThis study examined brain activities in people with Alzheimer's disease when viewing happy, sad, and fearful facial expressions of others. A functional magnetic resonance imaging and a voxel-based morphometry methodology together with a passive viewing of emotional faces paradigm were employed to compare the affective processing in 12 people with mild Alzheimer's disease and 12 matched controls. The main finding was that the clinical participants showed reduced activations in regions associated with the motor simulation system (the ventral premotor cortex) and in regions associated with emotional simulation-empathy (the anterior insula and adjacent frontal operculum). This regional decline in blood oxygen level-dependent signals appeared to be lateralized in the left hemisphere and was not related to any structural degeneration in the clinical participants. Furthermore, the regions that showed changes in neural activity differed for the 3 emotional facial expressions studied. Findings of our study indicate that neural changes in regions associated with the motor and emotional simulation systems might play an important role in the development of Alzheimer's disease. © 2012 Elsevier Inc. All rights reserved.en_US
dc.languageengen_US
dc.publisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/neuagingen_US
dc.relation.ispartofNeurobiology of Agingen_US
dc.subjectAlzheimer's Diseaseen_US
dc.subjectDementiaen_US
dc.subjectEmotional Facial Expressionsen_US
dc.subjectMirror Neuron Systemen_US
dc.titleNeural activities during affective processing in people with Alzheimer's diseaseen_US
dc.typeArticleen_US
dc.identifier.emailLee, TMC:tmclee@hku.hken_US
dc.identifier.emailSun, D:sundelin@hku.hken_US
dc.identifier.authorityLee, TMC=rp00564en_US
dc.identifier.authoritySun, D=rp00873en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/j.neurobiolaging.2012.06.018en_US
dc.identifier.pmid22840336-
dc.identifier.scopuseid_2-s2.0-84870501609en_US
dc.identifier.hkuros201607-
dc.identifier.eissn1558-1497-
dc.identifier.isiWOS:000313117900006-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridLee, TMC=7501437381en_US
dc.identifier.scopusauthoridSun, D=25029722800en_US
dc.identifier.scopusauthoridLeung, MK=55318913500en_US
dc.identifier.scopusauthoridChu, LW=55314710100en_US
dc.identifier.scopusauthoridKeysers, C=6603551269en_US

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