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Article: Activation of the hypothalamus characterizes the response to acupuncture stimulation in heroin addicts
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TitleActivation of the hypothalamus characterizes the response to acupuncture stimulation in heroin addicts
 
AuthorsLiu, S3
Zhou, W3
Ruan, X2
Li, R3
Lee, T4
Weng, X5
Hu, J1
Yang, G3
 
Issue Date2007
 
PublisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/neulet
 
CitationNeuroscience Letters, 2007, v. 421 n. 3, p. 203-208 [How to Cite?]
DOI: http://dx.doi.org/10.1016/j.neulet.2007.04.078
 
AbstractAcupuncture stimulation elicited a composite of sensations termed deqi that is related to clinical efficacy. Neurobiological studies have identified the hypothalamus as an important component in mediating the deqi. Functional changes in hypothalamus persist after abstinence in addicts. We investigated the activation in the hypothalamus associated with acupuncture stimulation in healthy volunteers and heroin addicts by fMRI. Cortisol level and psychophysical responses, including the deqi sensation (an acupuncture effect of needle-manipulation), anxiety, and sharp pain, were also assessed. The activation of the hypothalamus was more robust in the addicts than that in the healthy subjects during acupuncture stimulation. The deqi scores of the heroin addicts were significantly higher than those of the healthy subjects during acupuncture treatment. An acupuncture sensation scale predicted the activation of the hypothalamus associated with the deqi sensation. © 2007 Elsevier Ireland Ltd. All rights reserved.
 
ISSN0304-3940
2012 Impact Factor: 2.026
2012 SCImago Journal Rankings: 0.815
 
DOIhttp://dx.doi.org/10.1016/j.neulet.2007.04.078
 
ReferencesReferences in Scopus
 
DC FieldValue
dc.contributor.authorLiu, S
 
dc.contributor.authorZhou, W
 
dc.contributor.authorRuan, X
 
dc.contributor.authorLi, R
 
dc.contributor.authorLee, T
 
dc.contributor.authorWeng, X
 
dc.contributor.authorHu, J
 
dc.contributor.authorYang, G
 
dc.date.accessioned2012-10-08T03:40:53Z
 
dc.date.available2012-10-08T03:40:53Z
 
dc.date.issued2007
 
dc.description.abstractAcupuncture stimulation elicited a composite of sensations termed deqi that is related to clinical efficacy. Neurobiological studies have identified the hypothalamus as an important component in mediating the deqi. Functional changes in hypothalamus persist after abstinence in addicts. We investigated the activation in the hypothalamus associated with acupuncture stimulation in healthy volunteers and heroin addicts by fMRI. Cortisol level and psychophysical responses, including the deqi sensation (an acupuncture effect of needle-manipulation), anxiety, and sharp pain, were also assessed. The activation of the hypothalamus was more robust in the addicts than that in the healthy subjects during acupuncture stimulation. The deqi scores of the heroin addicts were significantly higher than those of the healthy subjects during acupuncture treatment. An acupuncture sensation scale predicted the activation of the hypothalamus associated with the deqi sensation. © 2007 Elsevier Ireland Ltd. All rights reserved.
 
dc.description.natureLink_to_subscribed_fulltext
 
dc.identifier.citationNeuroscience Letters, 2007, v. 421 n. 3, p. 203-208 [How to Cite?]
DOI: http://dx.doi.org/10.1016/j.neulet.2007.04.078
 
dc.identifier.doihttp://dx.doi.org/10.1016/j.neulet.2007.04.078
 
dc.identifier.epage208
 
dc.identifier.issn0304-3940
2012 Impact Factor: 2.026
2012 SCImago Journal Rankings: 0.815
 
dc.identifier.issue3
 
dc.identifier.pmid17574746
 
dc.identifier.scopuseid_2-s2.0-34250616704
 
dc.identifier.spage203
 
dc.identifier.urihttp://hdl.handle.net/10722/169026
 
dc.identifier.volume421
 
dc.languageeng
 
dc.publisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/neulet
 
dc.publisher.placeIreland
 
dc.relation.ispartofNeuroscience Letters
 
dc.relation.referencesReferences in Scopus
 
dc.subject.meshAcupuncture - Methods
 
dc.subject.meshAdult
 
dc.subject.meshHeroin Dependence - Pathology - Therapy
 
dc.subject.meshHumans
 
dc.subject.meshHydrocortisone - Blood
 
dc.subject.meshHypothalamus - Blood Supply - Physiopathology
 
dc.subject.meshImage Processing, Computer-Assisted - Methods
 
dc.subject.meshMagnetic Resonance Imaging - Methods
 
dc.subject.meshMale
 
dc.subject.meshOxygen - Blood
 
dc.subject.meshPsychophysics
 
dc.titleActivation of the hypothalamus characterizes the response to acupuncture stimulation in heroin addicts
 
dc.typeArticle
 
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<contributor.author>Lee, T</contributor.author>
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Author Affiliations
  1. Shanghai University of Traditional Chinese Medicine
  2. Ningbo First Hospital
  3. Ningbo Addiction Research and Treatment Center
  4. The University of Hong Kong
  5. Institute of Psychology Chinese Academy of Sciences