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Article: D-mannose as a preservative of glucose in blood samples

TitleD-mannose as a preservative of glucose in blood samples
Authors
Issue Date1992
PublisherAmerican Association for Clinical Chemistry, Inc. The Journal's web site is located at http://www.clinchem.org
Citation
Clinical Chemistry, 1992, v. 38 n. 3, p. 411-413 How to Cite?
AbstractWe studied the changes in blood glucose concentration in blood samples collected in heparinized specimen tubes containing no other preservative, or containing NaF, D-mannose, or a combination of NaF and D-mannose. Blood concentration in samples taken into NaF decreased by 0.40 mmol/L in the first 2 h; thereafter, there was no change. In samples collected into mannose there was a small but significant decrease in blood glucose concentration with time. When samples containing mannose were analyzed immediately after collection, the concentration of glucose was higher than in later analyses, probably because of an exchange of intracellular glucose for extracellular mannose. When a combination of NaF and mannose was used, the blood glucose concentration was relatively stable but slightly higher than nonpreserved samples for the next 24 h. However, samples containing mannose were unsuitable for electrolyte analysis. We conclude that a combination of D- mannose and NaF may be a better preservative for blood glucose than either compound alone.
Persistent Identifierhttp://hdl.handle.net/10722/168910
ISSN
2015 Impact Factor: 7.457
2015 SCImago Journal Rankings: 2.472
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorChan, AYWen_US
dc.contributor.authorHo, CSen_US
dc.contributor.authorChan, TYKen_US
dc.contributor.authorSwaminathan, Ren_US
dc.date.accessioned2012-10-08T03:39:35Z-
dc.date.available2012-10-08T03:39:35Z-
dc.date.issued1992en_US
dc.identifier.citationClinical Chemistry, 1992, v. 38 n. 3, p. 411-413en_US
dc.identifier.issn0009-9147en_US
dc.identifier.urihttp://hdl.handle.net/10722/168910-
dc.description.abstractWe studied the changes in blood glucose concentration in blood samples collected in heparinized specimen tubes containing no other preservative, or containing NaF, D-mannose, or a combination of NaF and D-mannose. Blood concentration in samples taken into NaF decreased by 0.40 mmol/L in the first 2 h; thereafter, there was no change. In samples collected into mannose there was a small but significant decrease in blood glucose concentration with time. When samples containing mannose were analyzed immediately after collection, the concentration of glucose was higher than in later analyses, probably because of an exchange of intracellular glucose for extracellular mannose. When a combination of NaF and mannose was used, the blood glucose concentration was relatively stable but slightly higher than nonpreserved samples for the next 24 h. However, samples containing mannose were unsuitable for electrolyte analysis. We conclude that a combination of D- mannose and NaF may be a better preservative for blood glucose than either compound alone.en_US
dc.languageengen_US
dc.publisherAmerican Association for Clinical Chemistry, Inc. The Journal's web site is located at http://www.clinchem.orgen_US
dc.relation.ispartofClinical Chemistryen_US
dc.subject.meshAdulten_US
dc.subject.meshBlood Glucose - Metabolismen_US
dc.subject.meshDrug Stabilityen_US
dc.subject.meshGlycolysis - Drug Effectsen_US
dc.subject.meshHumansen_US
dc.subject.meshKineticsen_US
dc.subject.meshMannose - Pharmacologyen_US
dc.subject.meshPotassium - Blooden_US
dc.subject.meshSodium - Blooden_US
dc.subject.meshSodium Fluoride - Pharmacologyen_US
dc.titleD-mannose as a preservative of glucose in blood samplesen_US
dc.typeArticleen_US
dc.identifier.emailHo, CS:shhoc@hkucc.hku.hken_US
dc.identifier.authorityHo, CS=rp00631en_US
dc.description.naturelink_to_OA_fulltexten_US
dc.identifier.pmid1547561-
dc.identifier.scopuseid_2-s2.0-0026576971en_US
dc.identifier.volume38en_US
dc.identifier.issue3en_US
dc.identifier.spage411en_US
dc.identifier.epage413en_US
dc.identifier.isiWOS:A1992HJ87000018-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridChan, AYW=7403167940en_US
dc.identifier.scopusauthoridHo, CS=35095289900en_US
dc.identifier.scopusauthoridChan, TYK=7402687410en_US
dc.identifier.scopusauthoridSwaminathan, R=15038300900en_US

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