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Article: New ruthenium(II) complexes functionalized with coumarin derivatives: Synthesis, energy-transfer-based sensing of esterase, cytotoxicity, and imaging studies

TitleNew ruthenium(II) complexes functionalized with coumarin derivatives: Synthesis, energy-transfer-based sensing of esterase, cytotoxicity, and imaging studies
Authors
KeywordsCoumarins
Energy Transfer
Luminescence
Ruthenium
Issue Date2012
PublisherWiley - V C H Verlag GmbH & Co KGaA. The Journal's web site is located at http://www.wiley-vch.de/home/chemistry
Citation
Chemistry - A European Journal, 2012, v. 18 n. 28, p. 8724-8730 How to Cite?
AbstractTwo new bichromophoric ruthenium(II) complexes, [Ru(bpy) 2(bpy-CM)](PF 6) 2 and [Ru(bpy) 2(bpy-CM343)](PF 6) 2 (bpy=2,2'-bipyridine, CM=coumarin) with appended coumarin ligands have been designed and synthesized. The energy-transfer-based sensing of esterase by the complexes has been studied by using UV/Vis and luminescence spectroscopic methods. The cytotoxicity and the cellular uptake of one of the complexes have also been investigated. Woodruff-not only tasty! Two new bichromophoric ruthenium(II) complexes with appended coumarin ligands have been synthesized. The energy-transfer-based sensing of esterase by the complexes was studied by using UV/Vis and luminescence spectroscopy. The Ru II complex containing a coumarin 343 derivative was found to exhibit only a slight cytotoxicity towards HepG2 cells, and it was easily taken up in the living cells to show evident response to the esterase (see figure). Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Persistent Identifierhttp://hdl.handle.net/10722/168651
ISSN
2015 Impact Factor: 5.771
2015 SCImago Journal Rankings: 2.323
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorLi, MJen_US
dc.contributor.authorWong, KMCen_US
dc.contributor.authorYi, Cen_US
dc.contributor.authorYam, VWWen_US
dc.date.accessioned2012-10-08T03:24:00Z-
dc.date.available2012-10-08T03:24:00Z-
dc.date.issued2012en_US
dc.identifier.citationChemistry - A European Journal, 2012, v. 18 n. 28, p. 8724-8730en_US
dc.identifier.issn0947-6539en_US
dc.identifier.urihttp://hdl.handle.net/10722/168651-
dc.description.abstractTwo new bichromophoric ruthenium(II) complexes, [Ru(bpy) 2(bpy-CM)](PF 6) 2 and [Ru(bpy) 2(bpy-CM343)](PF 6) 2 (bpy=2,2'-bipyridine, CM=coumarin) with appended coumarin ligands have been designed and synthesized. The energy-transfer-based sensing of esterase by the complexes has been studied by using UV/Vis and luminescence spectroscopic methods. The cytotoxicity and the cellular uptake of one of the complexes have also been investigated. Woodruff-not only tasty! Two new bichromophoric ruthenium(II) complexes with appended coumarin ligands have been synthesized. The energy-transfer-based sensing of esterase by the complexes was studied by using UV/Vis and luminescence spectroscopy. The Ru II complex containing a coumarin 343 derivative was found to exhibit only a slight cytotoxicity towards HepG2 cells, and it was easily taken up in the living cells to show evident response to the esterase (see figure). Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.en_US
dc.languageengen_US
dc.publisherWiley - V C H Verlag GmbH & Co KGaA. The Journal's web site is located at http://www.wiley-vch.de/home/chemistryen_US
dc.relation.ispartofChemistry - A European Journalen_US
dc.subjectCoumarinsen_US
dc.subjectEnergy Transferen_US
dc.subjectLuminescenceen_US
dc.subjectRutheniumen_US
dc.titleNew ruthenium(II) complexes functionalized with coumarin derivatives: Synthesis, energy-transfer-based sensing of esterase, cytotoxicity, and imaging studiesen_US
dc.typeArticleen_US
dc.identifier.emailWong, KMC:wongmc@hku.hken_US
dc.identifier.emailYam, VWW:wwyam@hku.hken_US
dc.identifier.authorityWong, KMC=rp00809en_US
dc.identifier.authorityYam, VWW=rp00822en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1002/chem.201103025en_US
dc.identifier.pmid22693144-
dc.identifier.scopuseid_2-s2.0-84863481505en_US
dc.identifier.hkuros219074-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-84863481505&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume18en_US
dc.identifier.issue28en_US
dc.identifier.spage8724en_US
dc.identifier.epage8730en_US
dc.identifier.isiWOS:000305942400024-
dc.publisher.placeGermanyen_US
dc.identifier.scopusauthoridLi, MJ=13105838700en_US
dc.identifier.scopusauthoridWong, KMC=8061067200en_US
dc.identifier.scopusauthoridYi, C=55260280300en_US
dc.identifier.scopusauthoridYam, VWW=18539304700en_US

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