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Article: DNA-Binding Small Molecules as Inhibitors of Transcription Factors

TitleDNA-Binding Small Molecules as Inhibitors of Transcription Factors
Authors
KeywordsGroove Binding
Inhibitor
Intercalation
Small Molecule
Transcription Factor
Issue Date2013
PublisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/34185
Citation
Medicinal Research Reviews, 2013, v. 33 n. 4, p. 823-846 How to Cite?
AbstractAccumulating evidence implicating the role of aberrant transcription factor signaling in the pathogenesis of various human diseases such as cancer and inflammation has stimulated the development of small molecule ligands capable of targeting transcription factor activity and modulating gene expression. The use of DNA-binding small molecules to selectively inhibit transcription factor-DNA interactions represents one possible approach toward this goal. In this review, we summarize the development of DNA-binding small molecule inhibitors of transcription factors from 2004 to 2011, and their binding mode and therapeutic potential will be discussed. © 2012 Wiley Periodicals, Inc.
Persistent Identifierhttp://hdl.handle.net/10722/168624
ISSN
2015 Impact Factor: 9.135
2015 SCImago Journal Rankings: 3.087
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorLeung, CHen_US
dc.contributor.authorChan, DSHen_US
dc.contributor.authorMa, VPYen_US
dc.contributor.authorMa, DLen_US
dc.date.accessioned2012-10-08T03:21:44Z-
dc.date.available2012-10-08T03:21:44Z-
dc.date.issued2013en_US
dc.identifier.citationMedicinal Research Reviews, 2013, v. 33 n. 4, p. 823-846en_US
dc.identifier.issn0198-6325en_US
dc.identifier.urihttp://hdl.handle.net/10722/168624-
dc.description.abstractAccumulating evidence implicating the role of aberrant transcription factor signaling in the pathogenesis of various human diseases such as cancer and inflammation has stimulated the development of small molecule ligands capable of targeting transcription factor activity and modulating gene expression. The use of DNA-binding small molecules to selectively inhibit transcription factor-DNA interactions represents one possible approach toward this goal. In this review, we summarize the development of DNA-binding small molecule inhibitors of transcription factors from 2004 to 2011, and their binding mode and therapeutic potential will be discussed. © 2012 Wiley Periodicals, Inc.en_US
dc.languageengen_US
dc.publisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/34185en_US
dc.relation.ispartofMedicinal Research Reviewsen_US
dc.subjectGroove Bindingen_US
dc.subjectInhibitoren_US
dc.subjectIntercalationen_US
dc.subjectSmall Moleculeen_US
dc.subjectTranscription Factoren_US
dc.titleDNA-Binding Small Molecules as Inhibitors of Transcription Factorsen_US
dc.typeArticleen_US
dc.identifier.emailLeung, CH:duncanl@hkucc.hku.hken_US
dc.identifier.emailMa, DL:edmondma@hku.hken_US
dc.identifier.authorityLeung, CH=rp00730en_US
dc.identifier.authorityMa, DL=rp00760en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1002/med.21266en_US
dc.identifier.pmid22549740-
dc.identifier.scopuseid_2-s2.0-84878656671en_US
dc.identifier.isiWOS:000319988700004-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridLeung, CH=7402612570en_US
dc.identifier.scopusauthoridChan, DSH=55066624100en_US
dc.identifier.scopusauthoridMa, VPY=53264450900en_US
dc.identifier.scopusauthoridMa, DL=7402075538en_US

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