Article: The role of the Golgi apparatus in oxidative stress: Is this organelle less significant than mitochondria?

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TitleThe role of the Golgi apparatus in oxidative stress: Is this organelle less significant than mitochondria?
AuthorsJiang, Z1
Hu, Z1
Zeng, L1
Lu, W1
Zhang, H1
Li, T1
Xiao, H1
Issue Date2011
PublisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/freeradbiomed
CitationFree Radical Biology And Medicine, 2011, v. 50 n. 8, p. 907-917 [How to Cite?]
DOI: http://dx.doi.org/10.1016/j.freeradbiomed.2011.01.011
AbstractReactive oxygen species (ROS)/reactive nitrogen species (RNS) and ROS/RNS-mediated oxidative stress have well-established roles in many physiological and pathological processes and are associated with the pathogenesis of many diseases, such as hypertension, ischemia/reperfusion injury, diabetes mellitus, atherosclerosis, stroke, cancer, and neurodegenerative disorders. It is generally accepted that mitochondria play an essential role in oxidative stress because they are responsible for the primary generation of superoxide radicals. Little attention, however, has been paid to the importance of the Golgi apparatus (GA) in this process. The GA is a pivotal organelle in cell metabolism and participates in modifying, sorting, and packaging macromolecules for cell secretion or use within the cell. It is inevitably involved in the process of oxidative stress, which can cause modification and damage of lipids, proteins, DNA, and other structural constituents. Here we discuss the connections between the GA and oxidative stress and highlight the role of the GA in oxidative stress-related Ca 2+/Mn 2+ homeostasis, cell apoptosis, sphingolipid metabolism, signal transduction, and antioxidation. We also provide a novel perspective on the subcellular significance of oxidative stress and its pathological implications and present "GA stress" as a new concept to explain the GA-specific stress response. © 2011 Elsevier Inc. All rights reserved.
ISSN0891-5849
2011 Impact Factor: 5.423
2011 SCImago Journal Rankings: 0.484
DOIhttp://dx.doi.org/10.1016/j.freeradbiomed.2011.01.011
ReferencesReferences in Scopus
DC Field
Value
dc.contributor.authorJiang, Z
dc.contributor.authorHu, Z
dc.contributor.authorZeng, L
dc.contributor.authorLu, W
dc.contributor.authorZhang, H
dc.contributor.authorLi, T
dc.contributor.authorXiao, H
dc.date.accessioned2012-10-08T03:19:52Z
dc.date.available2012-10-08T03:19:52Z
dc.date.issued2011
dc.description.abstractReactive oxygen species (ROS)/reactive nitrogen species (RNS) and ROS/RNS-mediated oxidative stress have well-established roles in many physiological and pathological processes and are associated with the pathogenesis of many diseases, such as hypertension, ischemia/reperfusion injury, diabetes mellitus, atherosclerosis, stroke, cancer, and neurodegenerative disorders. It is generally accepted that mitochondria play an essential role in oxidative stress because they are responsible for the primary generation of superoxide radicals. Little attention, however, has been paid to the importance of the Golgi apparatus (GA) in this process. The GA is a pivotal organelle in cell metabolism and participates in modifying, sorting, and packaging macromolecules for cell secretion or use within the cell. It is inevitably involved in the process of oxidative stress, which can cause modification and damage of lipids, proteins, DNA, and other structural constituents. Here we discuss the connections between the GA and oxidative stress and highlight the role of the GA in oxidative stress-related Ca 2+/Mn 2+ homeostasis, cell apoptosis, sphingolipid metabolism, signal transduction, and antioxidation. We also provide a novel perspective on the subcellular significance of oxidative stress and its pathological implications and present "GA stress" as a new concept to explain the GA-specific stress response. © 2011 Elsevier Inc. All rights reserved.
dc.description.natureLink_to_subscribed_fulltext
dc.identifier.citationFree Radical Biology And Medicine, 2011, v. 50 n. 8, p. 907-917 [How to Cite?]
DOI: http://dx.doi.org/10.1016/j.freeradbiomed.2011.01.011
dc.identifier.citeulike8643362
dc.identifier.doihttp://dx.doi.org/10.1016/j.freeradbiomed.2011.01.011
dc.identifier.epage917
dc.identifier.issn0891-5849
2011 Impact Factor: 5.423
2011 SCImago Journal Rankings: 0.484
dc.identifier.issue8
dc.identifier.pmid21241794
dc.identifier.scopuseid_2-s2.0-79952444868
dc.identifier.spage907
dc.identifier.urihttp://hdl.handle.net/10722/168514
dc.identifier.volume50
dc.languageeng
dc.publisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/freeradbiomed
dc.publisher.placeUnited States
dc.relation.ispartofFree Radical Biology and Medicine
dc.relation.referencesReferences in Scopus
dc.subject.meshAnimals
dc.subject.meshGolgi Apparatus - Physiology
dc.subject.meshHumans
dc.subject.meshMitochondria - Metabolism
dc.subject.meshOxidative Stress
dc.subject.meshRats
dc.subject.meshSpecies Specificity
dc.titleThe role of the Golgi apparatus in oxidative stress: Is this organelle less significant than mitochondria?
dc.typeArticle
Author Affiliations
  1. Second Xiangya Hospital of Central-South University