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Article: The role of the Golgi apparatus in oxidative stress: Is this organelle less significant than mitochondria?

TitleThe role of the Golgi apparatus in oxidative stress: Is this organelle less significant than mitochondria?
Authors
Issue Date2011
PublisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/freeradbiomed
Citation
Free Radical Biology And Medicine, 2011, v. 50 n. 8, p. 907-917 How to Cite?
Abstract
Reactive oxygen species (ROS)/reactive nitrogen species (RNS) and ROS/RNS-mediated oxidative stress have well-established roles in many physiological and pathological processes and are associated with the pathogenesis of many diseases, such as hypertension, ischemia/reperfusion injury, diabetes mellitus, atherosclerosis, stroke, cancer, and neurodegenerative disorders. It is generally accepted that mitochondria play an essential role in oxidative stress because they are responsible for the primary generation of superoxide radicals. Little attention, however, has been paid to the importance of the Golgi apparatus (GA) in this process. The GA is a pivotal organelle in cell metabolism and participates in modifying, sorting, and packaging macromolecules for cell secretion or use within the cell. It is inevitably involved in the process of oxidative stress, which can cause modification and damage of lipids, proteins, DNA, and other structural constituents. Here we discuss the connections between the GA and oxidative stress and highlight the role of the GA in oxidative stress-related Ca 2+/Mn 2+ homeostasis, cell apoptosis, sphingolipid metabolism, signal transduction, and antioxidation. We also provide a novel perspective on the subcellular significance of oxidative stress and its pathological implications and present "GA stress" as a new concept to explain the GA-specific stress response. © 2011 Elsevier Inc. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/168514
ISSN
2013 Impact Factor: 5.710
2013 SCImago Journal Rankings: 2.220
ISI Accession Number ID
References

 

Author Affiliations
  1. Second Xiangya Hospital of Central-South University
DC FieldValueLanguage
dc.contributor.authorJiang, Zen_US
dc.contributor.authorHu, Zen_US
dc.contributor.authorZeng, Len_US
dc.contributor.authorLu, Wen_US
dc.contributor.authorZhang, Hen_US
dc.contributor.authorLi, Ten_US
dc.contributor.authorXiao, Hen_US
dc.date.accessioned2012-10-08T03:19:52Z-
dc.date.available2012-10-08T03:19:52Z-
dc.date.issued2011en_US
dc.identifier.citationFree Radical Biology And Medicine, 2011, v. 50 n. 8, p. 907-917en_US
dc.identifier.issn0891-5849en_US
dc.identifier.urihttp://hdl.handle.net/10722/168514-
dc.description.abstractReactive oxygen species (ROS)/reactive nitrogen species (RNS) and ROS/RNS-mediated oxidative stress have well-established roles in many physiological and pathological processes and are associated with the pathogenesis of many diseases, such as hypertension, ischemia/reperfusion injury, diabetes mellitus, atherosclerosis, stroke, cancer, and neurodegenerative disorders. It is generally accepted that mitochondria play an essential role in oxidative stress because they are responsible for the primary generation of superoxide radicals. Little attention, however, has been paid to the importance of the Golgi apparatus (GA) in this process. The GA is a pivotal organelle in cell metabolism and participates in modifying, sorting, and packaging macromolecules for cell secretion or use within the cell. It is inevitably involved in the process of oxidative stress, which can cause modification and damage of lipids, proteins, DNA, and other structural constituents. Here we discuss the connections between the GA and oxidative stress and highlight the role of the GA in oxidative stress-related Ca 2+/Mn 2+ homeostasis, cell apoptosis, sphingolipid metabolism, signal transduction, and antioxidation. We also provide a novel perspective on the subcellular significance of oxidative stress and its pathological implications and present "GA stress" as a new concept to explain the GA-specific stress response. © 2011 Elsevier Inc. All rights reserved.en_US
dc.languageengen_US
dc.publisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/freeradbiomeden_US
dc.relation.ispartofFree Radical Biology and Medicineen_US
dc.subject.meshAnimalsen_US
dc.subject.meshGolgi Apparatus - Physiologyen_US
dc.subject.meshHumansen_US
dc.subject.meshMitochondria - Metabolismen_US
dc.subject.meshOxidative Stressen_US
dc.subject.meshRatsen_US
dc.subject.meshSpecies Specificityen_US
dc.titleThe role of the Golgi apparatus in oxidative stress: Is this organelle less significant than mitochondria?en_US
dc.typeArticleen_US
dc.identifier.emailLu, W:luwei@hku.hken_US
dc.identifier.authorityLu, W=rp00754en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/j.freeradbiomed.2011.01.011en_US
dc.identifier.pmid21241794en_US
dc.identifier.scopuseid_2-s2.0-79952444868en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-79952444868&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume50en_US
dc.identifier.issue8en_US
dc.identifier.spage907en_US
dc.identifier.epage917en_US
dc.identifier.isiWOS:000288818100001-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridJiang, Z=41861691600en_US
dc.identifier.scopusauthoridHu, Z=7404210124en_US
dc.identifier.scopusauthoridZeng, L=16647753300en_US
dc.identifier.scopusauthoridLu, W=27868087600en_US
dc.identifier.scopusauthoridZhang, H=35867714100en_US
dc.identifier.scopusauthoridLi, T=36096818400en_US
dc.identifier.scopusauthoridXiao, H=41862644200en_US
dc.identifier.citeulike8643362-

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