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Article: The role of the Golgi apparatus in oxidative stress: Is this organelle less significant than mitochondria?
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TitleThe role of the Golgi apparatus in oxidative stress: Is this organelle less significant than mitochondria?
 
AuthorsJiang, Z1
Hu, Z1
Zeng, L1
Lu, W1
Zhang, H1
Li, T1
Xiao, H1
 
Issue Date2011
 
PublisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/freeradbiomed
 
CitationFree Radical Biology And Medicine, 2011, v. 50 n. 8, p. 907-917 [How to Cite?]
DOI: http://dx.doi.org/10.1016/j.freeradbiomed.2011.01.011
 
AbstractReactive oxygen species (ROS)/reactive nitrogen species (RNS) and ROS/RNS-mediated oxidative stress have well-established roles in many physiological and pathological processes and are associated with the pathogenesis of many diseases, such as hypertension, ischemia/reperfusion injury, diabetes mellitus, atherosclerosis, stroke, cancer, and neurodegenerative disorders. It is generally accepted that mitochondria play an essential role in oxidative stress because they are responsible for the primary generation of superoxide radicals. Little attention, however, has been paid to the importance of the Golgi apparatus (GA) in this process. The GA is a pivotal organelle in cell metabolism and participates in modifying, sorting, and packaging macromolecules for cell secretion or use within the cell. It is inevitably involved in the process of oxidative stress, which can cause modification and damage of lipids, proteins, DNA, and other structural constituents. Here we discuss the connections between the GA and oxidative stress and highlight the role of the GA in oxidative stress-related Ca 2+/Mn 2+ homeostasis, cell apoptosis, sphingolipid metabolism, signal transduction, and antioxidation. We also provide a novel perspective on the subcellular significance of oxidative stress and its pathological implications and present "GA stress" as a new concept to explain the GA-specific stress response. © 2011 Elsevier Inc. All rights reserved.
 
ISSN0891-5849
2013 Impact Factor: 5.710
2013 SCImago Journal Rankings: 2.220
 
DOIhttp://dx.doi.org/10.1016/j.freeradbiomed.2011.01.011
 
ReferencesReferences in Scopus
 
DC FieldValue
dc.contributor.authorJiang, Z
 
dc.contributor.authorHu, Z
 
dc.contributor.authorZeng, L
 
dc.contributor.authorLu, W
 
dc.contributor.authorZhang, H
 
dc.contributor.authorLi, T
 
dc.contributor.authorXiao, H
 
dc.date.accessioned2012-10-08T03:19:52Z
 
dc.date.available2012-10-08T03:19:52Z
 
dc.date.issued2011
 
dc.description.abstractReactive oxygen species (ROS)/reactive nitrogen species (RNS) and ROS/RNS-mediated oxidative stress have well-established roles in many physiological and pathological processes and are associated with the pathogenesis of many diseases, such as hypertension, ischemia/reperfusion injury, diabetes mellitus, atherosclerosis, stroke, cancer, and neurodegenerative disorders. It is generally accepted that mitochondria play an essential role in oxidative stress because they are responsible for the primary generation of superoxide radicals. Little attention, however, has been paid to the importance of the Golgi apparatus (GA) in this process. The GA is a pivotal organelle in cell metabolism and participates in modifying, sorting, and packaging macromolecules for cell secretion or use within the cell. It is inevitably involved in the process of oxidative stress, which can cause modification and damage of lipids, proteins, DNA, and other structural constituents. Here we discuss the connections between the GA and oxidative stress and highlight the role of the GA in oxidative stress-related Ca 2+/Mn 2+ homeostasis, cell apoptosis, sphingolipid metabolism, signal transduction, and antioxidation. We also provide a novel perspective on the subcellular significance of oxidative stress and its pathological implications and present "GA stress" as a new concept to explain the GA-specific stress response. © 2011 Elsevier Inc. All rights reserved.
 
dc.description.natureLink_to_subscribed_fulltext
 
dc.identifier.citationFree Radical Biology And Medicine, 2011, v. 50 n. 8, p. 907-917 [How to Cite?]
DOI: http://dx.doi.org/10.1016/j.freeradbiomed.2011.01.011
 
dc.identifier.citeulike8643362
 
dc.identifier.doihttp://dx.doi.org/10.1016/j.freeradbiomed.2011.01.011
 
dc.identifier.epage917
 
dc.identifier.issn0891-5849
2013 Impact Factor: 5.710
2013 SCImago Journal Rankings: 2.220
 
dc.identifier.issue8
 
dc.identifier.pmid21241794
 
dc.identifier.scopuseid_2-s2.0-79952444868
 
dc.identifier.spage907
 
dc.identifier.urihttp://hdl.handle.net/10722/168514
 
dc.identifier.volume50
 
dc.languageeng
 
dc.publisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/freeradbiomed
 
dc.publisher.placeUnited States
 
dc.relation.ispartofFree Radical Biology and Medicine
 
dc.relation.referencesReferences in Scopus
 
dc.subject.meshAnimals
 
dc.subject.meshGolgi Apparatus - Physiology
 
dc.subject.meshHumans
 
dc.subject.meshMitochondria - Metabolism
 
dc.subject.meshOxidative Stress
 
dc.subject.meshRats
 
dc.subject.meshSpecies Specificity
 
dc.titleThe role of the Golgi apparatus in oxidative stress: Is this organelle less significant than mitochondria?
 
dc.typeArticle
 
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<contributor.author>Zhang, H</contributor.author>
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Author Affiliations
  1. Second Xiangya Hospital of Central-South University