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Article: Synergistic angiogenesis promoting effects of extracellular matrix scaffolds and adipose-derived stem cells during wound repair

TitleSynergistic angiogenesis promoting effects of extracellular matrix scaffolds and adipose-derived stem cells during wound repair
Authors
Issue Date2011
PublisherMary Ann Liebert, Inc. Publishers. The Journal's web site is located at http://www.liebertpub.com/publication.aspx?pub_id=263
Citation
Tissue Engineering - Part A, 2011, v. 17 n. 5-6, p. 725-739 How to Cite?
AbstractSlow vascularization rate is considered one of the main drawbacks of scaffolds used in wound healing. Several efforts, including cellular and acellular technologies, have been made to induce vascular growth in scaffolds. However, thus far, there is no established technology for inducing vascular growth. The aim of this study was to promote the vascularization capacities of scaffolds by seeding adipose-derived stem cells (ADSCs) on them and to compare the vascularization capacities of different scaffolds seeded with ADSCs. Two kinds of extracellular matrix scaffolds (small intestinal submucosa [SIS] and acellular dermal matrix [ADM]) and a kind of composite scaffold (collagen-chondroitin sulfate-hyaluronic acid [Co-CS-HA]) were selected. Subcutaneous implantation analysis showed that the vascularization capacity of SIS and ADM was greater than that of Co-CS-HA. ADSCs seeded in SIS and ADM secreted greater amounts of vascular endothelial growth factor than those seeded in Co-CS-HA. In a murine skin injury model, ADSC-seeded scaffolds enhanced the angiogenesis and wound healing rate compared with the nonseeded scaffolds. Moreover, ADSC-SIS and ADSC-ADM had greater vascularization capacity than that of ADSC-Co-CS-HA. Taken together, these results suggest that ADSCs could be used as a cell source to promote the vascularization capacities of scaffolds. The vascularization capacities of ADSC-seeded scaffolds were influenced by both the vascularization capacities of the scaffolds themselves and their effects on the angiogenic potential of ADSCs; the combination of extracellular matrix scaffolds and ADSCs exhibited synergistic angiogenesis promoting effects. © Mary Ann Liebert, Inc. 2011.
Persistent Identifierhttp://hdl.handle.net/10722/168512
ISSN
2015 SCImago Journal Rankings: 1.500
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorLiu, Sen_US
dc.contributor.authorZhang, Hen_US
dc.contributor.authorZhang, Xen_US
dc.contributor.authorLu, Wen_US
dc.contributor.authorHuang, Xen_US
dc.contributor.authorXie, Hen_US
dc.contributor.authorZhou, Jen_US
dc.contributor.authorWang, Wen_US
dc.contributor.authorZhang, Yen_US
dc.contributor.authorLiu, Yen_US
dc.contributor.authorDeng, Zen_US
dc.contributor.authorJin, Yen_US
dc.date.accessioned2012-10-08T03:19:51Z-
dc.date.available2012-10-08T03:19:51Z-
dc.date.issued2011en_US
dc.identifier.citationTissue Engineering - Part A, 2011, v. 17 n. 5-6, p. 725-739en_US
dc.identifier.issn1937-3341en_US
dc.identifier.urihttp://hdl.handle.net/10722/168512-
dc.description.abstractSlow vascularization rate is considered one of the main drawbacks of scaffolds used in wound healing. Several efforts, including cellular and acellular technologies, have been made to induce vascular growth in scaffolds. However, thus far, there is no established technology for inducing vascular growth. The aim of this study was to promote the vascularization capacities of scaffolds by seeding adipose-derived stem cells (ADSCs) on them and to compare the vascularization capacities of different scaffolds seeded with ADSCs. Two kinds of extracellular matrix scaffolds (small intestinal submucosa [SIS] and acellular dermal matrix [ADM]) and a kind of composite scaffold (collagen-chondroitin sulfate-hyaluronic acid [Co-CS-HA]) were selected. Subcutaneous implantation analysis showed that the vascularization capacity of SIS and ADM was greater than that of Co-CS-HA. ADSCs seeded in SIS and ADM secreted greater amounts of vascular endothelial growth factor than those seeded in Co-CS-HA. In a murine skin injury model, ADSC-seeded scaffolds enhanced the angiogenesis and wound healing rate compared with the nonseeded scaffolds. Moreover, ADSC-SIS and ADSC-ADM had greater vascularization capacity than that of ADSC-Co-CS-HA. Taken together, these results suggest that ADSCs could be used as a cell source to promote the vascularization capacities of scaffolds. The vascularization capacities of ADSC-seeded scaffolds were influenced by both the vascularization capacities of the scaffolds themselves and their effects on the angiogenic potential of ADSCs; the combination of extracellular matrix scaffolds and ADSCs exhibited synergistic angiogenesis promoting effects. © Mary Ann Liebert, Inc. 2011.en_US
dc.languageengen_US
dc.publisherMary Ann Liebert, Inc. Publishers. The Journal's web site is located at http://www.liebertpub.com/publication.aspx?pub_id=263en_US
dc.relation.ispartofTissue Engineering - Part Aen_US
dc.titleSynergistic angiogenesis promoting effects of extracellular matrix scaffolds and adipose-derived stem cells during wound repairen_US
dc.typeArticleen_US
dc.identifier.emailLu, W:luwei@hku.hken_US
dc.identifier.authorityLu, W=rp00754en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1089/ten.tea.2010.0331en_US
dc.identifier.pmid20929282-
dc.identifier.scopuseid_2-s2.0-79952172635en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-79952172635&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume17en_US
dc.identifier.issue5-6en_US
dc.identifier.spage725en_US
dc.identifier.epage739en_US
dc.identifier.isiWOS:000287801600013-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridLiu, S=37034522500en_US
dc.identifier.scopusauthoridZhang, H=36672274500en_US
dc.identifier.scopusauthoridZhang, X=36193441500en_US
dc.identifier.scopusauthoridLu, W=27868087600en_US
dc.identifier.scopusauthoridHuang, X=36179646600en_US
dc.identifier.scopusauthoridXie, H=37073654300en_US
dc.identifier.scopusauthoridZhou, J=35486332100en_US
dc.identifier.scopusauthoridWang, W=36193301800en_US
dc.identifier.scopusauthoridZhang, Y=35735685000en_US
dc.identifier.scopusauthoridLiu, Y=36071323100en_US
dc.identifier.scopusauthoridDeng, Z=15119136700en_US
dc.identifier.scopusauthoridJin, Y=26643271200en_US

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