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Article: Induction of Hormone Receptors and Responsiveness during Cellular Differentiation

TitleInduction of Hormone Receptors and Responsiveness during Cellular Differentiation
Authors
Issue Date1983
Citation
Current Topics In Membranes And Transport, 1983, v. 18 C, p. 287-315 How to Cite?
AbstractThe chapter focuses primarily on the hormone-sensitive adenylate cyclase system as one indication of the state of cellular differentiation. During the process of differentiation, cells acquire various specialized functions, and the responsiveness of cells to hormones is often associated with a more differentiated state. Differentiation is a complex process. Even when studying a single function, such as hormone sensitivity, numerous other factors must be considered. Therefore, by using cultured cells, the cellular environment can be brought under better control, thus reducing the number of variables within the experimentation. Due to adaptation to artificial growth conditions, established cell cultures often become partially dedifferentiated and, in many cases, no longer retain the initial cellular characteristics. Certain chemical compounds induce differentiated functions in several established cell lines. Friend erythroleukemic cells (a line of erythroblasts transformed with Friend leukemia virus) and HeLa cells derived from a human cervical carcinoma, are well characterized in this regard. Various model systems such as 3T3-LI adipocyte, liver cells, granulosa cells, and Madin-Darby Canine kidney (MDCK) cells are discussed.
Persistent Identifierhttp://hdl.handle.net/10722/168479
ISSN

 

DC FieldValueLanguage
dc.contributor.authorLin, MCen_US
dc.contributor.authorBeckner, SKen_US
dc.date.accessioned2012-10-08T03:19:26Z-
dc.date.available2012-10-08T03:19:26Z-
dc.date.issued1983en_US
dc.identifier.citationCurrent Topics In Membranes And Transport, 1983, v. 18 C, p. 287-315en_US
dc.identifier.issn0070-2161en_US
dc.identifier.urihttp://hdl.handle.net/10722/168479-
dc.description.abstractThe chapter focuses primarily on the hormone-sensitive adenylate cyclase system as one indication of the state of cellular differentiation. During the process of differentiation, cells acquire various specialized functions, and the responsiveness of cells to hormones is often associated with a more differentiated state. Differentiation is a complex process. Even when studying a single function, such as hormone sensitivity, numerous other factors must be considered. Therefore, by using cultured cells, the cellular environment can be brought under better control, thus reducing the number of variables within the experimentation. Due to adaptation to artificial growth conditions, established cell cultures often become partially dedifferentiated and, in many cases, no longer retain the initial cellular characteristics. Certain chemical compounds induce differentiated functions in several established cell lines. Friend erythroleukemic cells (a line of erythroblasts transformed with Friend leukemia virus) and HeLa cells derived from a human cervical carcinoma, are well characterized in this regard. Various model systems such as 3T3-LI adipocyte, liver cells, granulosa cells, and Madin-Darby Canine kidney (MDCK) cells are discussed.-
dc.languageengen_US
dc.relation.ispartofCurrent Topics in Membranes and Transporten_US
dc.titleInduction of Hormone Receptors and Responsiveness during Cellular Differentiationen_US
dc.typeArticleen_US
dc.identifier.emailLin, MC:mcllin@hkucc.hku.hken_US
dc.identifier.authorityLin, MC=rp00746en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/S0070-2161(08)60534-1en_US
dc.identifier.scopuseid_2-s2.0-77957800900en_US
dc.identifier.volume18en_US
dc.identifier.issueCen_US
dc.identifier.spage287en_US
dc.identifier.epage315en_US
dc.identifier.scopusauthoridLin, MC=7404816359en_US
dc.identifier.scopusauthoridBeckner, SK=7004064238en_US

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