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Article: L-Cysteine-capped CdTe quantum dots as a fluorescence probe for determination of cardiolipin

TitleL-Cysteine-capped CdTe quantum dots as a fluorescence probe for determination of cardiolipin
Authors
Issue Date2010
PublisherJapan Society for Analytical Chemistry. The Journal's web site is located at http://wwwsoc.nii.ac.jp/jsac/analsci.html
Citation
Analytical Sciences, 2010, v. 26 n. 8, p. 879-884 How to Cite?
AbstractThis paper described the investigation of surface-modified quantum dots (QDs) as a fluorescence probe for the detection of cardiolipin. A single-step method for preparation of non-toxic and photo-stable cadmium telluride (CdTe) QDs capped by L-cysteine in aqueous solution was developed. The prepared QDs were characterized by high-resolution transmission electron microscopy, X-ray diffraction spectrometry, Fourier transform infrared spectrometry and spectrofluorometry. These functional QDs were used as a fluorescence probe for cardiolipin determination based on the fluorescence quenching. The optimum fluorescence intensity was found to be at pH 7.4 with QDs concentration of 4 × 10 -5 mol L -1. The effect of other phospholipids on the intensity of CdTe QDs showed a low interference response. Under optimized conditions, the quenched fluorescence intensity was linear with the concentration of cardiolipin in the range of 1.33 × 10 -7 - 10.4 × 10 -7 mol L -1 (r = 0.9976) and a detection limit (S/N = 3) of 18.5 nmol L -1. The proposed method was applied to the determination of cardiolipin content of HepG2 cell samples before and after oxidative stress with satisfactory results. 2010 © The Japan Society for Analytical Chemistry.
Persistent Identifierhttp://hdl.handle.net/10722/168472
ISSN
2015 Impact Factor: 1.174
2015 SCImago Journal Rankings: 0.427
References

 

DC FieldValueLanguage
dc.contributor.authorZhao, Wen_US
dc.contributor.authorFung, Yen_US
dc.contributor.authorO, Wen_US
dc.contributor.authorCheung, MPLen_US
dc.date.accessioned2012-10-08T03:19:22Z-
dc.date.available2012-10-08T03:19:22Z-
dc.date.issued2010en_US
dc.identifier.citationAnalytical Sciences, 2010, v. 26 n. 8, p. 879-884en_US
dc.identifier.issn0910-6340en_US
dc.identifier.urihttp://hdl.handle.net/10722/168472-
dc.description.abstractThis paper described the investigation of surface-modified quantum dots (QDs) as a fluorescence probe for the detection of cardiolipin. A single-step method for preparation of non-toxic and photo-stable cadmium telluride (CdTe) QDs capped by L-cysteine in aqueous solution was developed. The prepared QDs were characterized by high-resolution transmission electron microscopy, X-ray diffraction spectrometry, Fourier transform infrared spectrometry and spectrofluorometry. These functional QDs were used as a fluorescence probe for cardiolipin determination based on the fluorescence quenching. The optimum fluorescence intensity was found to be at pH 7.4 with QDs concentration of 4 × 10 -5 mol L -1. The effect of other phospholipids on the intensity of CdTe QDs showed a low interference response. Under optimized conditions, the quenched fluorescence intensity was linear with the concentration of cardiolipin in the range of 1.33 × 10 -7 - 10.4 × 10 -7 mol L -1 (r = 0.9976) and a detection limit (S/N = 3) of 18.5 nmol L -1. The proposed method was applied to the determination of cardiolipin content of HepG2 cell samples before and after oxidative stress with satisfactory results. 2010 © The Japan Society for Analytical Chemistry.en_US
dc.languageengen_US
dc.publisherJapan Society for Analytical Chemistry. The Journal's web site is located at http://wwwsoc.nii.ac.jp/jsac/analsci.htmlen_US
dc.relation.ispartofAnalytical Sciencesen_US
dc.subject.meshCadmium Compounds - Chemistryen_US
dc.subject.meshCardiolipins - Analysisen_US
dc.subject.meshCysteine - Chemistryen_US
dc.subject.meshHep G2 Cellsen_US
dc.subject.meshHumansen_US
dc.subject.meshLimit Of Detectionen_US
dc.subject.meshMicroscopy, Electron, Transmissionen_US
dc.subject.meshOxidative Stressen_US
dc.subject.meshQuantum Dotsen_US
dc.subject.meshSpectrometry, Fluorescence - Methodsen_US
dc.subject.meshSpectroscopy, Fourier Transform Infrareden_US
dc.subject.meshTellurium - Chemistryen_US
dc.subject.meshX-Ray Diffractionen_US
dc.titleL-Cysteine-capped CdTe quantum dots as a fluorescence probe for determination of cardiolipinen_US
dc.typeArticleen_US
dc.identifier.emailFUNG, Y:ysfung@hku.hken_US
dc.identifier.authorityFUNG, Y=rp00697en_US
dc.identifier.authorityO, W=rp00315-
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.2116/analsci.26.879en_US
dc.identifier.pmid20702942-
dc.identifier.scopuseid_2-s2.0-77955757215en_US
dc.identifier.hkuros181346-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-77955757215&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume26en_US
dc.identifier.issue8en_US
dc.identifier.spage879en_US
dc.identifier.epage884en_US
dc.publisher.placeJapanen_US
dc.identifier.scopusauthoridZhao, W=34871080300en_US
dc.identifier.scopusauthoridFUNG, Y=13309754700en_US
dc.identifier.scopusauthoridO, W=37027584100en_US
dc.identifier.scopusauthoridCheung, MPL=16749051200en_US

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