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Article: Conformational studies on peptides of α-aminoxy acids with functionalized side-chains

TitleConformational studies on peptides of α-aminoxy acids with functionalized side-chains
Authors
KeywordsCircular dichroism
Conformation analysis
Gelical structures
Hydrogen bonds
Peptides
Issue Date2010
PublisherWiley - V C H Verlag GmbH & Co. KGaA. The Journal's web site is located at http://www.wiley-vch.de/publish/en/journals/alphabeticIndex/2451
Citation
Chemistry - An Asian Journal, 2010, v. 5 n. 6, p. 1356-1363 How to Cite?
AbstractPeptides of homochiral α- aminoxy acids of nonpolar side chains can form a 1.88-helix. In this paper, we report the conformational studies of α- aminoxy peptides 1-3, which have functionalized side chains, in both non- polar and polar solvents. 1H NMR, XRD, and FTIR absorption studies confirm the presence of the eight-membered-ring intramolecular hydrogen bonds (the N-O turns) in nonpolar solvents as well as in methanol. CD studies of peptides 1-3 in different solvents indicate that a substantial degree of helical content is retained in methanol and acidic aqueous buffers. The introduction of functionalized side chains in α-aminoxy peptides provides opportunities for designing biologically active peptides.
Persistent Identifierhttp://hdl.handle.net/10722/168460
ISSN
2015 Impact Factor: 4.592
2015 SCImago Journal Rankings: 1.833
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorYang, Den_HK
dc.contributor.authorLiu, GJen_HK
dc.contributor.authorHao, Yen_HK
dc.contributor.authorLi, Wen_HK
dc.contributor.authorDong, ZMen_HK
dc.contributor.authorZhang, DWen_HK
dc.contributor.authorZhu, NYen_HK
dc.date.accessioned2012-10-08T03:19:12Z-
dc.date.available2012-10-08T03:19:12Z-
dc.date.issued2010en_HK
dc.identifier.citationChemistry - An Asian Journal, 2010, v. 5 n. 6, p. 1356-1363en_HK
dc.identifier.issn1861-4728en_HK
dc.identifier.urihttp://hdl.handle.net/10722/168460-
dc.description.abstractPeptides of homochiral α- aminoxy acids of nonpolar side chains can form a 1.88-helix. In this paper, we report the conformational studies of α- aminoxy peptides 1-3, which have functionalized side chains, in both non- polar and polar solvents. 1H NMR, XRD, and FTIR absorption studies confirm the presence of the eight-membered-ring intramolecular hydrogen bonds (the N-O turns) in nonpolar solvents as well as in methanol. CD studies of peptides 1-3 in different solvents indicate that a substantial degree of helical content is retained in methanol and acidic aqueous buffers. The introduction of functionalized side chains in α-aminoxy peptides provides opportunities for designing biologically active peptides.en_HK
dc.languageengen_US
dc.publisherWiley - V C H Verlag GmbH & Co. KGaA. The Journal's web site is located at http://www.wiley-vch.de/publish/en/journals/alphabeticIndex/2451en_HK
dc.relation.ispartofChemistry - An Asian Journalen_HK
dc.subjectCircular dichroismen_HK
dc.subjectConformation analysisen_HK
dc.subjectGelical structuresen_HK
dc.subjectHydrogen bondsen_HK
dc.subjectPeptidesen_HK
dc.subject.meshAcids - Chemistryen_US
dc.subject.meshAmino Acids - Chemistryen_US
dc.subject.meshCircular Dichroismen_US
dc.subject.meshCrystallography, X-Rayen_US
dc.subject.meshHydrogen Bondingen_US
dc.subject.meshNuclear Magnetic Resonance, Biomolecularen_US
dc.subject.meshOligopeptides - Chemistryen_US
dc.subject.meshProtein Structure, Secondaryen_US
dc.subject.meshSpectroscopy, Fourier Transform Infrareden_US
dc.titleConformational studies on peptides of α-aminoxy acids with functionalized side-chainsen_HK
dc.typeArticleen_HK
dc.identifier.emailYang, D: yangdan@hku.hken_HK
dc.identifier.emailZhu, NY: nzhu@hkucc.hku.hken_HK
dc.identifier.authorityYang, D=rp00825en_HK
dc.identifier.authorityZhu, NY=rp00845en_HK
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1002/asia.200900636en_HK
dc.identifier.pmid20408163-
dc.identifier.scopuseid_2-s2.0-77952909043en_HK
dc.identifier.hkuros180944-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-77952909043&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume5en_HK
dc.identifier.issue6en_HK
dc.identifier.spage1356en_HK
dc.identifier.epage1363en_HK
dc.identifier.isiWOS:000278840200014-
dc.publisher.placeGermanyen_HK
dc.identifier.scopusauthoridYang, D=7404800756en_HK
dc.identifier.scopusauthoridLiu, GJ=25823290000en_HK
dc.identifier.scopusauthoridHao, Y=7201593182en_HK
dc.identifier.scopusauthoridLi, W=36064044700en_HK
dc.identifier.scopusauthoridDong, ZM=7402274471en_HK
dc.identifier.scopusauthoridZhang, DW=35320759400en_HK
dc.identifier.scopusauthoridZhu, NY=7201449530en_HK

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