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Article: Metallomics: An integrated biometal science

TitleMetallomics: An integrated biometal science
Authors
KeywordsChemical Speciation
Metallodrug
Metallome
Metallomics
Metalloprotein
Issue Date2009
PublisherScience in China Press. The Journal's web site is located at http://219.238.6.200/journal?code=04
Citation
Science In China, Series B: Chemistry, 2009, v. 52 n. 12, p. 2055-2070 How to Cite?
AbstractMetallomics is an emerging scientific area integrating the research fields related to the understanding of the molecular mechanisms of metal-associated life processes and the entirety of metal and metalloid species within a cell or tissue type. In metallomics, metalloproteins, metalloenzymes and other metal-containing biomolecules in a biological system are referred to as metallomes, similar to genomes and proteomes in genomics and proteomics, respectively. This review discusses the concept of metallomics with a focus on analytical techniques and methods, particularly the so-called hyphenated techniques which combine a high-resolution separation technique (gel electrophoresis/laser ablation, chromatography or capillary electrophoresis) with a highly sensitive detection method such as elemental (inductively coupled plasma, ICP) or molecular (electron spray ionization (ESI) or matrix-assisted laser desorption/ionization (MALDI)) mass spectrometry, or nuclear X-ray fluorescence/absorption spectrometry. The applications of these advanced analytical methods in the identification of metallo-/phospho-/seleno-proteins, probing of relationships between structure and function of metalloproteins, and study of clinically used metallodrugs will be selectively outlined, along with their advantages and limitations. © 2009 Science in China Press and Springer Berlin Heidelberg.
Persistent Identifierhttp://hdl.handle.net/10722/168431
ISSN
2011 Impact Factor: 1.199
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorGe, Ren_US
dc.contributor.authorSun, Hen_US
dc.date.accessioned2012-10-08T03:18:51Z-
dc.date.available2012-10-08T03:18:51Z-
dc.date.issued2009en_US
dc.identifier.citationScience In China, Series B: Chemistry, 2009, v. 52 n. 12, p. 2055-2070en_US
dc.identifier.issn1006-9291en_US
dc.identifier.urihttp://hdl.handle.net/10722/168431-
dc.description.abstractMetallomics is an emerging scientific area integrating the research fields related to the understanding of the molecular mechanisms of metal-associated life processes and the entirety of metal and metalloid species within a cell or tissue type. In metallomics, metalloproteins, metalloenzymes and other metal-containing biomolecules in a biological system are referred to as metallomes, similar to genomes and proteomes in genomics and proteomics, respectively. This review discusses the concept of metallomics with a focus on analytical techniques and methods, particularly the so-called hyphenated techniques which combine a high-resolution separation technique (gel electrophoresis/laser ablation, chromatography or capillary electrophoresis) with a highly sensitive detection method such as elemental (inductively coupled plasma, ICP) or molecular (electron spray ionization (ESI) or matrix-assisted laser desorption/ionization (MALDI)) mass spectrometry, or nuclear X-ray fluorescence/absorption spectrometry. The applications of these advanced analytical methods in the identification of metallo-/phospho-/seleno-proteins, probing of relationships between structure and function of metalloproteins, and study of clinically used metallodrugs will be selectively outlined, along with their advantages and limitations. © 2009 Science in China Press and Springer Berlin Heidelberg.en_US
dc.languageengen_US
dc.publisherScience in China Press. The Journal's web site is located at http://219.238.6.200/journal?code=04en_US
dc.relation.ispartofScience in China, Series B: Chemistryen_US
dc.subjectChemical Speciationen_US
dc.subjectMetallodrugen_US
dc.subjectMetallomeen_US
dc.subjectMetallomicsen_US
dc.subjectMetalloproteinen_US
dc.titleMetallomics: An integrated biometal scienceen_US
dc.typeArticleen_US
dc.identifier.emailSun, H:hsun@hkucc.hku.hken_US
dc.identifier.authoritySun, H=rp00777en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1007/s11426-009-0144-6en_US
dc.identifier.scopuseid_2-s2.0-75749115160en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-75749115160&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume52en_US
dc.identifier.issue12en_US
dc.identifier.spage2055en_US
dc.identifier.epage2070en_US
dc.identifier.isiWOS:000272917200006-
dc.publisher.placeChinaen_US
dc.identifier.scopusauthoridGe, R=7005525090en_US
dc.identifier.scopusauthoridSun, H=7404827446en_US
dc.identifier.citeulike6445196-

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