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Article: Synthetic chloride channel regulates cell membrane potentials and voltage-gated calcium channels

TitleSynthetic chloride channel regulates cell membrane potentials and voltage-gated calcium channels
Authors
Issue Date2009
PublisherAmerican Chemical Society. The Journal's web site is located at http://pubs.acs.org/journals/jacsat/index.html
Citation
Journal Of The American Chemical Society, 2009, v. 131 n. 38, p. 13676-13680 How to Cite?
AbstractSynthetic ion channels are of great interest in mimicking the biological functions of natural ion channels. Although many synthetic ion channels could selectively mediate ion transport across lipid bilayer membranes, the biological roles played by these synthetic channels in living systems remain essentially obscure. In this study, we report the application of a synthetic chloride (Cl -) channel as a powerful tool to perturb and regulate a series of biological processes related or coupled to the changes of cell membrane potentials. This is the first example in which an artificial ion channel can regulate natural voltage-gated calcium channels, intracellular calcium concentrations, and the contraction of smooth muscle cells via modulating cell membrane potentials in living cells and tissues. The present study on the ability of the synthetic chloride channel to perturb functions of natural ion channels may open new perspectives for the applications of other synthetic ion channels in biological systems. © 2009 American Chemical Society.
Persistent Identifierhttp://hdl.handle.net/10722/168405
ISSN
2015 Impact Factor: 13.038
2015 SCImago Journal Rankings: 7.123
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorLi, Xen_US
dc.contributor.authorShen, Ben_US
dc.contributor.authorYao, XQen_US
dc.contributor.authorYang, Den_US
dc.date.accessioned2012-10-08T03:18:33Z-
dc.date.available2012-10-08T03:18:33Z-
dc.date.issued2009en_US
dc.identifier.citationJournal Of The American Chemical Society, 2009, v. 131 n. 38, p. 13676-13680en_US
dc.identifier.issn0002-7863en_US
dc.identifier.urihttp://hdl.handle.net/10722/168405-
dc.description.abstractSynthetic ion channels are of great interest in mimicking the biological functions of natural ion channels. Although many synthetic ion channels could selectively mediate ion transport across lipid bilayer membranes, the biological roles played by these synthetic channels in living systems remain essentially obscure. In this study, we report the application of a synthetic chloride (Cl -) channel as a powerful tool to perturb and regulate a series of biological processes related or coupled to the changes of cell membrane potentials. This is the first example in which an artificial ion channel can regulate natural voltage-gated calcium channels, intracellular calcium concentrations, and the contraction of smooth muscle cells via modulating cell membrane potentials in living cells and tissues. The present study on the ability of the synthetic chloride channel to perturb functions of natural ion channels may open new perspectives for the applications of other synthetic ion channels in biological systems. © 2009 American Chemical Society.en_US
dc.languageengen_US
dc.publisherAmerican Chemical Society. The Journal's web site is located at http://pubs.acs.org/journals/jacsat/index.htmlen_US
dc.relation.ispartofJournal of the American Chemical Societyen_US
dc.subject.meshCalcium Channels, L-Type - Drug Effectsen_US
dc.subject.meshCell Membrane - Drug Effectsen_US
dc.subject.meshChloride Channels - Chemical Synthesis - Chemistry - Pharmacologyen_US
dc.subject.meshIon Channel Gating - Drug Effectsen_US
dc.subject.meshMembrane Potentials - Drug Effectsen_US
dc.subject.meshMolecular Mimicryen_US
dc.subject.meshPhthalic Acids - Chemical Synthesis - Chemistry - Pharmacologyen_US
dc.titleSynthetic chloride channel regulates cell membrane potentials and voltage-gated calcium channelsen_US
dc.typeArticleen_US
dc.identifier.emailYang, D:yangdan@hku.hken_US
dc.identifier.authorityYang, D=rp00825en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1021/ja902352gen_US
dc.identifier.pmid19772362-
dc.identifier.scopuseid_2-s2.0-70349739273en_US
dc.identifier.hkuros180939-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-70349739273&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume131en_US
dc.identifier.issue38en_US
dc.identifier.spage13676en_US
dc.identifier.epage13680en_US
dc.identifier.eissn1520-5126-
dc.identifier.isiWOS:000270186600037-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridLi, X=25932179600en_US
dc.identifier.scopusauthoridShen, B=8958686600en_US
dc.identifier.scopusauthoridYao, XQ=7402529434en_US
dc.identifier.scopusauthoridYang, D=7404800756en_US
dc.identifier.citeulike5841474-

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