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Article: MicroRNA-15b regulates cell cycle progression by targeting cyclins in glioma cells

TitleMicroRNA-15b regulates cell cycle progression by targeting cyclins in glioma cells
Authors
KeywordsCCNE1
Cell cycle
Glioblastoma
MicroRNA
MiR-15b
Issue Date2009
PublisherAcademic Press. The Journal's web site is located at http://www.elsevier.com/wps/find/journaldescription.cws_home/622790/description
Citation
Biochemical And Biophysical Research Communications, 2009, v. 380 n. 2, p. 205-210 How to Cite?
AbstractMicroRNAs (miRNAs) are non-protein-coding RNAs that function as post-transcriptional gene regulators. Recent evidence has shown that miRNA plays a pivotal role in the development of many cancers including glioma, a lethal brain cancer. We have recently compared the miRNA expression profiles between normal brain and glioma tissues from Chinese patients by miRNA microarray and identified a panel of differentially expressed miRNAs. Here, we studied the function of one miRNA, miR-15b, in glioma carcinogenesis and elucidated its downstream targets. Over-expression of miR-15b resulted in cell cycle arrest at G0/G1 phase while suppression of miR-15b expression resulted in a decrease of cell populations in G0/G1 and a corresponding increase of cell populations in S phase. We further showed that CCNE1 (encoding cyclin E1) is one of the downstream targets of miR-15b. Taken together, our findings indicate that miR-15b regulates cell cycle progression in glioma cells by targeting cell cycle-related molecules. © 2009 Elsevier Inc. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/168360
ISSN
2015 Impact Factor: 2.371
2015 SCImago Journal Rankings: 1.152
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorXia, Hen_HK
dc.contributor.authorQi, Yen_HK
dc.contributor.authorNg, SSen_HK
dc.contributor.authorChen, Xen_HK
dc.contributor.authorChen, Sen_HK
dc.contributor.authorFang, Men_HK
dc.contributor.authorLi, Den_HK
dc.contributor.authorZhao, Yen_HK
dc.contributor.authorGe, Ren_HK
dc.contributor.authorLi, Gen_HK
dc.contributor.authorChen, Yen_HK
dc.contributor.authorHe, MLen_HK
dc.contributor.authorKung, Hfen_HK
dc.contributor.authorLai, Len_HK
dc.contributor.authorLin, MCen_HK
dc.date.accessioned2012-10-08T03:17:59Z-
dc.date.available2012-10-08T03:17:59Z-
dc.date.issued2009en_HK
dc.identifier.citationBiochemical And Biophysical Research Communications, 2009, v. 380 n. 2, p. 205-210en_HK
dc.identifier.issn0006-291Xen_HK
dc.identifier.urihttp://hdl.handle.net/10722/168360-
dc.description.abstractMicroRNAs (miRNAs) are non-protein-coding RNAs that function as post-transcriptional gene regulators. Recent evidence has shown that miRNA plays a pivotal role in the development of many cancers including glioma, a lethal brain cancer. We have recently compared the miRNA expression profiles between normal brain and glioma tissues from Chinese patients by miRNA microarray and identified a panel of differentially expressed miRNAs. Here, we studied the function of one miRNA, miR-15b, in glioma carcinogenesis and elucidated its downstream targets. Over-expression of miR-15b resulted in cell cycle arrest at G0/G1 phase while suppression of miR-15b expression resulted in a decrease of cell populations in G0/G1 and a corresponding increase of cell populations in S phase. We further showed that CCNE1 (encoding cyclin E1) is one of the downstream targets of miR-15b. Taken together, our findings indicate that miR-15b regulates cell cycle progression in glioma cells by targeting cell cycle-related molecules. © 2009 Elsevier Inc. All rights reserved.en_HK
dc.languageengen_US
dc.publisherAcademic Press. The Journal's web site is located at http://www.elsevier.com/wps/find/journaldescription.cws_home/622790/descriptionen_HK
dc.relation.ispartofBiochemical and Biophysical Research Communicationsen_HK
dc.subjectCCNE1en_HK
dc.subjectCell cycleen_HK
dc.subjectGlioblastomaen_HK
dc.subjectMicroRNAen_HK
dc.subjectMiR-15ben_HK
dc.subject.meshBrain - Metabolism - Pathologyen_US
dc.subject.meshBrain Neoplasms - Genetics - Pathologyen_US
dc.subject.meshCell Cycle - Geneticsen_US
dc.subject.meshCell Line, Tumoren_US
dc.subject.meshCell Transformation, Neoplastic - Genetics - Pathologyen_US
dc.subject.meshCyclins - Geneticsen_US
dc.subject.meshGene Expression Regulation, Neoplasticen_US
dc.subject.meshGlioma - Genetics - Pathologyen_US
dc.subject.meshHumansen_US
dc.subject.meshMicrornas - Genetics - Metabolismen_US
dc.titleMicroRNA-15b regulates cell cycle progression by targeting cyclins in glioma cellsen_HK
dc.typeArticleen_HK
dc.identifier.emailNg, SS: ssmng@hku.hken_HK
dc.identifier.emailLin, MC: mcllin@hkucc.hku.hken_HK
dc.identifier.authorityNg, SS=rp00767en_HK
dc.identifier.authorityLin, MC=rp00746en_HK
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/j.bbrc.2008.12.169en_HK
dc.identifier.pmid19135980-
dc.identifier.scopuseid_2-s2.0-60349094358en_HK
dc.identifier.hkuros154237-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-60349094358&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume380en_HK
dc.identifier.issue2en_HK
dc.identifier.spage205en_HK
dc.identifier.epage210en_HK
dc.identifier.isiWOS:000263742200001-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridXia, H=12545165300en_HK
dc.identifier.scopusauthoridQi, Y=24171887800en_HK
dc.identifier.scopusauthoridNg, SS=7403358718en_HK
dc.identifier.scopusauthoridChen, X=24170717900en_HK
dc.identifier.scopusauthoridChen, S=15757054600en_HK
dc.identifier.scopusauthoridFang, M=8664493500en_HK
dc.identifier.scopusauthoridLi, D=26324923700en_HK
dc.identifier.scopusauthoridZhao, Y=7406634118en_HK
dc.identifier.scopusauthoridGe, R=7005525090en_HK
dc.identifier.scopusauthoridLi, G=7407055832en_HK
dc.identifier.scopusauthoridChen, Y=24075600300en_HK
dc.identifier.scopusauthoridHe, ML=35080389700en_HK
dc.identifier.scopusauthoridKung, Hf=7402514190en_HK
dc.identifier.scopusauthoridLai, L=12445800200en_HK
dc.identifier.scopusauthoridLin, MC=7404816359en_HK
dc.identifier.citeulike3886186-

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