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Article: Discovery of a drug-like G-quadruplex binding ligand by high-throughput docking

TitleDiscovery of a drug-like G-quadruplex binding ligand by high-throughput docking
Authors
KeywordsDna
G-Quadruplexes
High-Throughput Docking
Ligands
Selectivity
Issue Date2008
PublisherWiley - V C H Verlag GmbH & Co KGaA. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/110485305
Citation
Chemmedchem, 2008, v. 3 n. 6, p. 881-884 How to Cite?
Abstract(Figure Presented) A new G-quadruplex binding ligand, namely 1H-pyrazole-3-carboxy-4-methyl-5-phenyl-(1H-indol-3-ylmethylene)hydrazide, was identified from a database of 100 000 drug-like compounds by in silico high-throughput docking. This compound was demonstrated experimentally to be an effective stabilizer of G-quadruplex DNA; it exhibits high selectivity for G-quadruplex over duplex DNA. © 2008 Wiley-VCH Verlag GmbH & Co. KGaA.
Persistent Identifierhttp://hdl.handle.net/10722/168314
ISSN
2014 Impact Factor: 2.968
2014 SCImago Journal Rankings: 0.988
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorMa, DLen_US
dc.contributor.authorLai, TSen_US
dc.contributor.authorChan, FYen_US
dc.contributor.authorChung, WHen_US
dc.contributor.authorAbagyan, Ren_US
dc.contributor.authorLeung, YCen_US
dc.contributor.authorWong, KYen_US
dc.date.accessioned2012-10-08T03:17:25Z-
dc.date.available2012-10-08T03:17:25Z-
dc.date.issued2008en_US
dc.identifier.citationChemmedchem, 2008, v. 3 n. 6, p. 881-884en_US
dc.identifier.issn1860-7179en_US
dc.identifier.urihttp://hdl.handle.net/10722/168314-
dc.description.abstract(Figure Presented) A new G-quadruplex binding ligand, namely 1H-pyrazole-3-carboxy-4-methyl-5-phenyl-(1H-indol-3-ylmethylene)hydrazide, was identified from a database of 100 000 drug-like compounds by in silico high-throughput docking. This compound was demonstrated experimentally to be an effective stabilizer of G-quadruplex DNA; it exhibits high selectivity for G-quadruplex over duplex DNA. © 2008 Wiley-VCH Verlag GmbH & Co. KGaA.en_US
dc.languageengen_US
dc.publisherWiley - V C H Verlag GmbH & Co KGaA. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/110485305en_US
dc.relation.ispartofChemMedChemen_US
dc.subjectDnaen_US
dc.subjectG-Quadruplexesen_US
dc.subjectHigh-Throughput Dockingen_US
dc.subjectLigandsen_US
dc.subjectSelectivityen_US
dc.titleDiscovery of a drug-like G-quadruplex binding ligand by high-throughput dockingen_US
dc.typeArticleen_US
dc.identifier.emailMa, DL:edmondma@hku.hken_US
dc.identifier.authorityMa, DL=rp00760en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1002/cmdc.200700342en_US
dc.identifier.pmid18383062-
dc.identifier.scopuseid_2-s2.0-48149094964en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-48149094964&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume3en_US
dc.identifier.issue6en_US
dc.identifier.spage881en_US
dc.identifier.epage884en_US
dc.identifier.isiWOS:000256975900004-
dc.publisher.placeGermanyen_US
dc.identifier.scopusauthoridMa, DL=7402075538en_US
dc.identifier.scopusauthoridLai, TS=7202203490en_US
dc.identifier.scopusauthoridChan, FY=36719313500en_US
dc.identifier.scopusauthoridChung, WH=8722115800en_US
dc.identifier.scopusauthoridAbagyan, R=7006710879en_US
dc.identifier.scopusauthoridLeung, YC=35074432700en_US
dc.identifier.scopusauthoridWong, KY=7404760030en_US

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