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Article: Reversal of multidrug resistance in cancer cells by Rhizoma Alismatis extract

TitleReversal of multidrug resistance in cancer cells by Rhizoma Alismatis extract
Authors
Issue Date2007
PublisherUrban und Fischer Verlag. The Journal's web site is located at http://www.elsevier.com/locate/phytomed
Citation
Phytomedicine, 2007, v. 14 n. 2-3, p. 160-165 How to Cite?
AbstractProlonged chemotherapy may lead to the selective proliferation of multidrug resistant (MDR) cancer cells. In MDR HepG2-DR and K562-DR cells that over-expressed P-glycoprotein (Pgp), the extract of the rhizomes of Alisma orientalis (Sam) Juzep. showed a synergistic growth inhibitory effect with cancer drugs that are Pgp substrates including actinomycin D, puromycin, paclitaxel, vinblastine and doxorubicin. At the same toxicity levels the herbal extract was more effective than verapamil, a standard Pgp inhibitor, in enhancing cellular doxorubicin accumulation and preventing the efflux of rhodamin-123 from the MDR cells. The extract restored the effect of vinblastine on the induction of G 2/M arrest in MDR cells. Our data suggest that A. orientalis may contain components that are effective inhibitors of Pgp. © 2006 Elsevier GmbH. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/168092
ISSN
2015 Impact Factor: 2.937
2015 SCImago Journal Rankings: 1.013
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorFong, WFen_US
dc.contributor.authorWang, Cen_US
dc.contributor.authorZhu, GYen_US
dc.contributor.authorLeung, CHen_US
dc.contributor.authorYang, MSen_US
dc.contributor.authorCheung, HYen_US
dc.date.accessioned2012-10-08T03:14:58Z-
dc.date.available2012-10-08T03:14:58Z-
dc.date.issued2007en_US
dc.identifier.citationPhytomedicine, 2007, v. 14 n. 2-3, p. 160-165en_US
dc.identifier.issn0944-7113en_US
dc.identifier.urihttp://hdl.handle.net/10722/168092-
dc.description.abstractProlonged chemotherapy may lead to the selective proliferation of multidrug resistant (MDR) cancer cells. In MDR HepG2-DR and K562-DR cells that over-expressed P-glycoprotein (Pgp), the extract of the rhizomes of Alisma orientalis (Sam) Juzep. showed a synergistic growth inhibitory effect with cancer drugs that are Pgp substrates including actinomycin D, puromycin, paclitaxel, vinblastine and doxorubicin. At the same toxicity levels the herbal extract was more effective than verapamil, a standard Pgp inhibitor, in enhancing cellular doxorubicin accumulation and preventing the efflux of rhodamin-123 from the MDR cells. The extract restored the effect of vinblastine on the induction of G 2/M arrest in MDR cells. Our data suggest that A. orientalis may contain components that are effective inhibitors of Pgp. © 2006 Elsevier GmbH. All rights reserved.en_US
dc.languageengen_US
dc.publisherUrban und Fischer Verlag. The Journal's web site is located at http://www.elsevier.com/locate/phytomeden_US
dc.relation.ispartofPhytomedicineen_US
dc.subject.meshAlismaen_US
dc.subject.meshAntineoplastic Agents - Administration & Dosage - Pharmacology - Therapeutic Useen_US
dc.subject.meshCell Line, Tumor - Drug Effects - Metabolismen_US
dc.subject.meshDrug Resistance, Multiple - Drug Effectsen_US
dc.subject.meshDrug Resistance, Neoplasm - Drug Effectsen_US
dc.subject.meshDrug Synergismen_US
dc.subject.meshHumansen_US
dc.subject.meshInhibitory Concentration 50en_US
dc.subject.meshP-Glycoprotein - Metabolismen_US
dc.subject.meshPhytotherapyen_US
dc.subject.meshPlant Extracts - Administration & Dosage - Pharmacology - Therapeutic Useen_US
dc.titleReversal of multidrug resistance in cancer cells by Rhizoma Alismatis extracten_US
dc.typeArticleen_US
dc.identifier.emailLeung, CH:duncanl@hkucc.hku.hken_US
dc.identifier.authorityLeung, CH=rp00730en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/j.phymed.2006.03.004en_US
dc.identifier.pmid16713217-
dc.identifier.scopuseid_2-s2.0-33846397852en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-33846397852&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume14en_US
dc.identifier.issue2-3en_US
dc.identifier.spage160en_US
dc.identifier.epage165en_US
dc.identifier.isiWOS:000244975200012-
dc.publisher.placeGermanyen_US
dc.identifier.scopusauthoridFong, WF=7102816013en_US
dc.identifier.scopusauthoridWang, C=35220849500en_US
dc.identifier.scopusauthoridZhu, GY=7402633140en_US
dc.identifier.scopusauthoridLeung, CH=7402612570en_US
dc.identifier.scopusauthoridYang, MS=7404925734en_US
dc.identifier.scopusauthoridCheung, HY=7201839371en_US

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