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- Publisher Website: 10.1073/pnas.0604998104
- Scopus: eid_2-s2.0-33845963902
- PMID: 17179048
- WOS: WOS:000243285500010
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Article: Single-stranded nucleic acid-induced helical self-assembly of alkynylplatinum(II) terpyridyl complexes
Title | Single-stranded nucleic acid-induced helical self-assembly of alkynylplatinum(II) terpyridyl complexes |
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Authors | |
Keywords | Helicity Noncovalent interactions Platinum complex |
Issue Date | 2006 |
Publisher | National Academy of Sciences. The Journal's web site is located at http://www.pnas.org |
Citation | Proceedings of the National Academy of Sciences of the United States of America, 2006, v. 103 n. 52, p. 19652-19657 How to Cite? |
Abstract | Single-stranded nucleic acids, which carry multiple negative charges in an aqueous medium at near neutral pH, are found to induce the aggregation and self-assembly of the positively charged alkynylplatinum(II) terpyridyl complexes via electrostatic binding of the platinum complexes to the single-stranded nucleic acids, as revealed by the appearance of new UV-vis absorption and emission bands upon addition of single-stranded nucleic acids to a buffer solution of the complex. Changes in the intensity and pattern of circular dichroism (CD) spectroscopy are also observed, many of which are consistent with the assembly of the platinum complexes into helical structures, via metal⋯metal and π⋯π stacking interactions. The induced spectroscopic property changes are found to depend on the structural properties of the nucleic acids. © 2006 by The National Academy of Sciences of the USA. |
Persistent Identifier | http://hdl.handle.net/10722/168088 |
ISSN | 2023 Impact Factor: 9.4 2023 SCImago Journal Rankings: 3.737 |
PubMed Central ID | |
ISI Accession Number ID | |
References |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Yu, C | en_US |
dc.contributor.author | Chan, KHY | en_US |
dc.contributor.author | Wong, KMC | en_US |
dc.contributor.author | Yam, VWW | en_US |
dc.date.accessioned | 2012-10-08T03:14:55Z | - |
dc.date.available | 2012-10-08T03:14:55Z | - |
dc.date.issued | 2006 | en_US |
dc.identifier.citation | Proceedings of the National Academy of Sciences of the United States of America, 2006, v. 103 n. 52, p. 19652-19657 | en_US |
dc.identifier.issn | 0027-8424 | en_US |
dc.identifier.uri | http://hdl.handle.net/10722/168088 | - |
dc.description.abstract | Single-stranded nucleic acids, which carry multiple negative charges in an aqueous medium at near neutral pH, are found to induce the aggregation and self-assembly of the positively charged alkynylplatinum(II) terpyridyl complexes via electrostatic binding of the platinum complexes to the single-stranded nucleic acids, as revealed by the appearance of new UV-vis absorption and emission bands upon addition of single-stranded nucleic acids to a buffer solution of the complex. Changes in the intensity and pattern of circular dichroism (CD) spectroscopy are also observed, many of which are consistent with the assembly of the platinum complexes into helical structures, via metal⋯metal and π⋯π stacking interactions. The induced spectroscopic property changes are found to depend on the structural properties of the nucleic acids. © 2006 by The National Academy of Sciences of the USA. | en_US |
dc.language | eng | en_US |
dc.publisher | National Academy of Sciences. The Journal's web site is located at http://www.pnas.org | en_US |
dc.relation.ispartof | Proceedings of the National Academy of Sciences of the United States of America | en_US |
dc.subject | Helicity | - |
dc.subject | Noncovalent interactions | - |
dc.subject | Platinum complex | - |
dc.subject.mesh | Nucleic Acid Conformation | en_US |
dc.subject.mesh | Nucleic Acids - Chemistry | en_US |
dc.subject.mesh | Organoplatinum Compounds - Chemistry | en_US |
dc.subject.mesh | Spectrum Analysis | en_US |
dc.title | Single-stranded nucleic acid-induced helical self-assembly of alkynylplatinum(II) terpyridyl complexes | en_US |
dc.type | Article | en_US |
dc.identifier.email | Wong, KMC:wongmc@hku.hk | en_US |
dc.identifier.email | Yam, VWW:wwyam@hku.hk | en_US |
dc.identifier.authority | Wong, KMC=rp00809 | en_US |
dc.identifier.authority | Yam, VWW=rp00822 | en_US |
dc.description.nature | link_to_OA_fulltext | en_US |
dc.identifier.doi | 10.1073/pnas.0604998104 | en_US |
dc.identifier.pmid | 17179048 | - |
dc.identifier.pmcid | PMC1750871 | - |
dc.identifier.scopus | eid_2-s2.0-33845963902 | en_US |
dc.identifier.hkuros | 136479 | - |
dc.relation.references | http://www.scopus.com/mlt/select.url?eid=2-s2.0-33845963902&selection=ref&src=s&origin=recordpage | en_US |
dc.identifier.volume | 103 | en_US |
dc.identifier.issue | 52 | en_US |
dc.identifier.spage | 19652 | en_US |
dc.identifier.epage | 19657 | en_US |
dc.identifier.isi | WOS:000243285500010 | - |
dc.publisher.place | United States | en_US |
dc.identifier.scopusauthorid | Yu, C=35486097900 | en_US |
dc.identifier.scopusauthorid | Chan, KHY=7406035175 | en_US |
dc.identifier.scopusauthorid | Wong, KMC=8061067200 | en_US |
dc.identifier.scopusauthorid | Yam, VWW=18539304700 | en_US |
dc.identifier.citeulike | 2157389 | - |
dc.identifier.issnl | 0027-8424 | - |