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Article: Single-stranded nucleic acid-induced helical self-assembly of alkynylplatinum(II) terpyridyl complexes

TitleSingle-stranded nucleic acid-induced helical self-assembly of alkynylplatinum(II) terpyridyl complexes
Authors
Issue Date2006
PublisherNational Academy of Sciences. The Journal's web site is located at http://www.pnas.org
Citation
Proceedings Of The National Academy Of Sciences Of The United States Of America, 2006, v. 103 n. 52, p. 19652-19657 How to Cite?
AbstractSingle-stranded nucleic acids, which carry multiple negative charges in an aqueous medium at near neutral pH, are found to induce the aggregation and self-assembly of the positively charged alkynylplatinum(II) terpyridyl complexes via electrostatic binding of the platinum complexes to the single-stranded nucleic acids, as revealed by the appearance of new UV-vis absorption and emission bands upon addition of single-stranded nucleic acids to a buffer solution of the complex. Changes in the intensity and pattern of circular dichroism (CD) spectroscopy are also observed, many of which are consistent with the assembly of the platinum complexes into helical structures, via metal⋯metal and π⋯π stacking interactions. The induced spectroscopic property changes are found to depend on the structural properties of the nucleic acids. © 2006 by The National Academy of Sciences of the USA.
Persistent Identifierhttp://hdl.handle.net/10722/168088
ISSN
2015 Impact Factor: 9.423
2015 SCImago Journal Rankings: 6.883
PubMed Central ID
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorYu, Cen_US
dc.contributor.authorChan, KHYen_US
dc.contributor.authorWong, KMCen_US
dc.contributor.authorYam, VWWen_US
dc.date.accessioned2012-10-08T03:14:55Z-
dc.date.available2012-10-08T03:14:55Z-
dc.date.issued2006en_US
dc.identifier.citationProceedings Of The National Academy Of Sciences Of The United States Of America, 2006, v. 103 n. 52, p. 19652-19657en_US
dc.identifier.issn0027-8424en_US
dc.identifier.urihttp://hdl.handle.net/10722/168088-
dc.description.abstractSingle-stranded nucleic acids, which carry multiple negative charges in an aqueous medium at near neutral pH, are found to induce the aggregation and self-assembly of the positively charged alkynylplatinum(II) terpyridyl complexes via electrostatic binding of the platinum complexes to the single-stranded nucleic acids, as revealed by the appearance of new UV-vis absorption and emission bands upon addition of single-stranded nucleic acids to a buffer solution of the complex. Changes in the intensity and pattern of circular dichroism (CD) spectroscopy are also observed, many of which are consistent with the assembly of the platinum complexes into helical structures, via metal⋯metal and π⋯π stacking interactions. The induced spectroscopic property changes are found to depend on the structural properties of the nucleic acids. © 2006 by The National Academy of Sciences of the USA.en_US
dc.languageengen_US
dc.publisherNational Academy of Sciences. The Journal's web site is located at http://www.pnas.orgen_US
dc.relation.ispartofProceedings of the National Academy of Sciences of the United States of Americaen_US
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.subject.meshNucleic Acid Conformationen_US
dc.subject.meshNucleic Acids - Chemistryen_US
dc.subject.meshOrganoplatinum Compounds - Chemistryen_US
dc.subject.meshSpectrum Analysisen_US
dc.titleSingle-stranded nucleic acid-induced helical self-assembly of alkynylplatinum(II) terpyridyl complexesen_US
dc.typeArticleen_US
dc.identifier.emailWong, KMC:wongmc@hku.hken_US
dc.identifier.emailYam, VWW:wwyam@hku.hken_US
dc.identifier.authorityWong, KMC=rp00809en_US
dc.identifier.authorityYam, VWW=rp00822en_US
dc.description.naturepublished_or_final_versionen_US
dc.identifier.doi10.1073/pnas.0604998104en_US
dc.identifier.pmid17179048-
dc.identifier.pmcidPMC1750871-
dc.identifier.scopuseid_2-s2.0-33845963902en_US
dc.identifier.hkuros136479-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-33845963902&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume103en_US
dc.identifier.issue52en_US
dc.identifier.spage19652en_US
dc.identifier.epage19657en_US
dc.identifier.isiWOS:000243285500010-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridYu, C=35486097900en_US
dc.identifier.scopusauthoridChan, KHY=7406035175en_US
dc.identifier.scopusauthoridWong, KMC=8061067200en_US
dc.identifier.scopusauthoridYam, VWW=18539304700en_US
dc.identifier.citeulike2157389-

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