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Article: Tumor necrosis factor-α-induced protein 1 and immunity to hepatitis B virus

TitleTumor necrosis factor-α-induced protein 1 and immunity to hepatitis B virus
Authors
Issue Date2005
PublisherBaishideng Publishing Group. The Journal's web site is located at http://www.wjgnet.com/1007-9327/index.htm
Citation
World Journal Of Gastroenterology, 2005, v. 11 n. 48, p. 7564-7568 How to Cite?
AbstractAim: To compare the gene expression profile in a pair of HBV-infected twins. Methods: The gene expression profile was compared in a pair of H BV-infected twins. Results: The twins displayed different disease outco mes. One acquired natural immunity against HBV, whereas the other became a chronic HBV carrier. Eighty-eight and forty-six genes were found to be up- or downregulated in their PBMCs, respectively. Tumor necrosis factor-alpha-induced protein 1 (TNF-αIP1) that expressed at a higher level in the HBV-immune twins was identified and four pairs of siblings with HBV immunity by RT-PCR. However, upon HBV core antigen stimulation, TNF-αIP1 was downregulated in PBMCs from subjects with immunity, whereas it was slightly upregulated in HBV carriers. Bioinformatics analysis revealed a K+ channel tetramerization domain in TNF-αIP1 that shares a significant homology with some human, mouse, and C elegan proteins. Conclusion: TNF-αIP1 may play a role in the innate immunity against HBV. © 2005 The WJG Press and Elsevier Inc. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/167999
ISSN
2015 Impact Factor: 2.787
2015 SCImago Journal Rankings: 1.076
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorLin, MCen_US
dc.contributor.authorLee, NPen_US
dc.contributor.authorZheng, Nen_US
dc.contributor.authorYang, PHen_US
dc.contributor.authorWong, OGen_US
dc.contributor.authorKung, HFen_US
dc.contributor.authorHui, CKen_US
dc.contributor.authorLuk, JMen_US
dc.contributor.authorLau, GKKen_US
dc.date.accessioned2012-10-08T03:13:57Z-
dc.date.available2012-10-08T03:13:57Z-
dc.date.issued2005en_US
dc.identifier.citationWorld Journal Of Gastroenterology, 2005, v. 11 n. 48, p. 7564-7568en_US
dc.identifier.issn1007-9327en_US
dc.identifier.urihttp://hdl.handle.net/10722/167999-
dc.description.abstractAim: To compare the gene expression profile in a pair of HBV-infected twins. Methods: The gene expression profile was compared in a pair of H BV-infected twins. Results: The twins displayed different disease outco mes. One acquired natural immunity against HBV, whereas the other became a chronic HBV carrier. Eighty-eight and forty-six genes were found to be up- or downregulated in their PBMCs, respectively. Tumor necrosis factor-alpha-induced protein 1 (TNF-αIP1) that expressed at a higher level in the HBV-immune twins was identified and four pairs of siblings with HBV immunity by RT-PCR. However, upon HBV core antigen stimulation, TNF-αIP1 was downregulated in PBMCs from subjects with immunity, whereas it was slightly upregulated in HBV carriers. Bioinformatics analysis revealed a K+ channel tetramerization domain in TNF-αIP1 that shares a significant homology with some human, mouse, and C elegan proteins. Conclusion: TNF-αIP1 may play a role in the innate immunity against HBV. © 2005 The WJG Press and Elsevier Inc. All rights reserved.en_US
dc.languageengen_US
dc.publisherBaishideng Publishing Group. The Journal's web site is located at http://www.wjgnet.com/1007-9327/index.htmen_US
dc.relation.ispartofWorld Journal of Gastroenterologyen_US
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.subject.meshAmino Acid Sequenceen_US
dc.subject.meshDiseases In Twinsen_US
dc.subject.meshGene Expression Profilingen_US
dc.subject.meshGene Expression Regulationen_US
dc.subject.meshHepatitis B Virus - Immunologyen_US
dc.subject.meshHumansen_US
dc.subject.meshImmunity, Innateen_US
dc.subject.meshInterleukin-18 Receptor Alpha Subuniten_US
dc.subject.meshMolecular Sequence Dataen_US
dc.subject.meshProteins - Genetics - Physiologyen_US
dc.subject.meshReceptors, Interleukin - Geneticsen_US
dc.subject.meshReceptors, Interleukin-18en_US
dc.titleTumor necrosis factor-α-induced protein 1 and immunity to hepatitis B virusen_US
dc.typeArticleen_US
dc.identifier.emailLin, MC:mcllin@hkucc.hku.hken_US
dc.identifier.emailLee, NP:nikkilee@hku.hken_US
dc.identifier.emailLuk, JM:jmluk@hkucc.hku.hken_US
dc.identifier.authorityLin, MC=rp00746en_US
dc.identifier.authorityLee, NP=rp00263en_US
dc.identifier.authorityLuk, JM=rp00349en_US
dc.description.naturepublished_or_final_versionen_US
dc.identifier.doi10.3748/wjg.v11.i48.7564-
dc.identifier.pmid16437679-
dc.identifier.scopuseid_2-s2.0-31644438942en_US
dc.identifier.hkuros115689-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-31644438942&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume11en_US
dc.identifier.issue48en_US
dc.identifier.spage7564en_US
dc.identifier.epage7568en_US
dc.identifier.isiWOS:000208157800003-
dc.publisher.placeChinaen_US
dc.identifier.scopusauthoridLin, MC=7404816359en_US
dc.identifier.scopusauthoridLee, NP=7402722690en_US
dc.identifier.scopusauthoridZheng, N=36724059100en_US
dc.identifier.scopusauthoridYang, PH=24340289000en_US
dc.identifier.scopusauthoridWong, OG=7004813981en_US
dc.identifier.scopusauthoridKung, HF=7402514190en_US
dc.identifier.scopusauthoridHui, CK=7202876933en_US
dc.identifier.scopusauthoridLuk, JM=7006777791en_US
dc.identifier.scopusauthoridLau, GKK=7102301257en_US

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