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Article: Facile generation of tripeptide radical cations in vacuo via intramolecular electron transfer in Cu II tripeptide complexes containing sterically encumbered terpyridine ligands

TitleFacile generation of tripeptide radical cations in vacuo via intramolecular electron transfer in Cu II tripeptide complexes containing sterically encumbered terpyridine ligands
Authors
Issue Date2005
PublisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/jasms
Citation
Journal Of The American Society For Mass Spectrometry, 2005, v. 16 n. 5, p. 763-771 How to Cite?
AbstractMolecular radical cations of tripeptides of the form glycylglycyl(residue X) (GGX •+) are produced by the collision-induced, intramolecular one-electron transfer of [Cu(II)(L)GGX] •2+ complexes (L = triamine ligand). We demonstrate, for the first time, the formation of molecular radical cations of all of the aliphatic, basic, aromatic, acidic, and some heteroatom-bearing GGX tripeptides, albeit inefficiently in some cases, by altering the structure of the auxiliary polyamine ligand bound to the copper atom. The design of the ligand allows exquisite control over the nature of the dissociation pathway. Steric hindrance of bulky groups in the ligand affects the binding of the peptide to the copper ion; this interaction is an important factor in determining whether the electron transfer pathway predominates. © 2005 American Society for Mass Spectrometry.
Persistent Identifierhttp://hdl.handle.net/10722/167915
ISSN
2015 Impact Factor: 3.031
2015 SCImago Journal Rankings: 1.322
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorChu, IKen_US
dc.contributor.authorLam, CNWen_US
dc.contributor.authorSiu, SOen_US
dc.date.accessioned2012-10-08T03:12:54Z-
dc.date.available2012-10-08T03:12:54Z-
dc.date.issued2005en_US
dc.identifier.citationJournal Of The American Society For Mass Spectrometry, 2005, v. 16 n. 5, p. 763-771en_US
dc.identifier.issn1044-0305en_US
dc.identifier.urihttp://hdl.handle.net/10722/167915-
dc.description.abstractMolecular radical cations of tripeptides of the form glycylglycyl(residue X) (GGX •+) are produced by the collision-induced, intramolecular one-electron transfer of [Cu(II)(L)GGX] •2+ complexes (L = triamine ligand). We demonstrate, for the first time, the formation of molecular radical cations of all of the aliphatic, basic, aromatic, acidic, and some heteroatom-bearing GGX tripeptides, albeit inefficiently in some cases, by altering the structure of the auxiliary polyamine ligand bound to the copper atom. The design of the ligand allows exquisite control over the nature of the dissociation pathway. Steric hindrance of bulky groups in the ligand affects the binding of the peptide to the copper ion; this interaction is an important factor in determining whether the electron transfer pathway predominates. © 2005 American Society for Mass Spectrometry.en_US
dc.languageengen_US
dc.publisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/jasmsen_US
dc.relation.ispartofJournal of the American Society for Mass Spectrometryen_US
dc.subject.meshCationsen_US
dc.subject.meshCopper - Analysis - Chemistryen_US
dc.subject.meshElectron Transporten_US
dc.subject.meshLigandsen_US
dc.subject.meshPeptides - Analysis - Chemistryen_US
dc.subject.meshProtein Bindingen_US
dc.subject.meshPyridines - Analysis - Chemistryen_US
dc.subject.meshSpectrometry, Mass, Electrospray Ionization - Methodsen_US
dc.subject.meshStereoisomerismen_US
dc.titleFacile generation of tripeptide radical cations in vacuo via intramolecular electron transfer in Cu II tripeptide complexes containing sterically encumbered terpyridine ligandsen_US
dc.typeArticleen_US
dc.identifier.emailChu, IK:ivankchu@hku.hken_US
dc.identifier.authorityChu, IK=rp00683en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/j.jasms.2005.01.026en_US
dc.identifier.pmid15862777-
dc.identifier.scopuseid_2-s2.0-18044382705en_US
dc.identifier.hkuros98452-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-18044382705&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume16en_US
dc.identifier.issue5en_US
dc.identifier.spage763en_US
dc.identifier.epage771en_US
dc.identifier.isiWOS:000228875000015-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridChu, IK=7103327484en_US
dc.identifier.scopusauthoridLam, CNW=7402990888en_US
dc.identifier.scopusauthoridSiu, SO=8603087200en_US

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