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Article: Bis-intercalative dinuclear platinum(II) 6-phenyl-2,2′-bipyridine complexes exhibit enhanced DNA affinity but similar cytotoxicity compared to the mononuclear unit

TitleBis-intercalative dinuclear platinum(II) 6-phenyl-2,2′-bipyridine complexes exhibit enhanced DNA affinity but similar cytotoxicity compared to the mononuclear unit
Authors
Issue Date2003
PublisherSpringer Verlag. The Journal's web site is located at http://link.springer.de/link/service/journals/00775/index.htm
Citation
Journal Of Biological Inorganic Chemistry, 2003, v. 8 n. 7, p. 761-769 How to Cite?
AbstractThe interactions between a series of platinum complexes, including (pyridyl)(6-phenyl-2,2′-bipyridine) platinum(II) hexafluorophosphate (1), three dinuclear bis[(6-phenyl-2,2′-bipyridine)platinum(II)] complexes (2-4), and (4-aminopyridine)(4,6-diphenyl-2,2′-bipyridine)platinum(II) perchlorate (5) with DNA have been investigated. All Pt(II) complexes, except 5, were demonstrated to be DNA intercalators, based on viscosity measurements. Absorption and fluorescence titration results indicated that the addition of a phenyl ring to the 6-phenyl-2,2′-bipyridine ligand dramatically reduced the DNA binding of the Pt(II) complex 5. The dinuclear complexes 2-4 exhibited multiple binding modes of mono/bisintercalation and groove binding, as revealed by viscosity and fluorescence titration measurements. While complexes 2-4 bound to DNA with significantly enhanced affinities as compared to 1, compounds 1 and 2-4 showed similar IC50 values against a panel of cancer cell lines. In addition, these complexes showed similar cellular uptakes. The results indicated that the cytotoxicity of these (6-phenyl-2,2′ -bipyridine)platinum compounds may not be mediated through DNA binding but may involve interacting mechanisms with cellular components other than DNA.
Persistent Identifierhttp://hdl.handle.net/10722/167833
ISSN
2015 Impact Factor: 2.495
2015 SCImago Journal Rankings: 0.882
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorChan, HLen_US
dc.contributor.authorMa, DLen_US
dc.contributor.authorYang, Men_US
dc.contributor.authorChe, CMen_US
dc.date.accessioned2012-10-08T03:12:02Z-
dc.date.available2012-10-08T03:12:02Z-
dc.date.issued2003en_US
dc.identifier.citationJournal Of Biological Inorganic Chemistry, 2003, v. 8 n. 7, p. 761-769en_US
dc.identifier.issn0949-8257en_US
dc.identifier.urihttp://hdl.handle.net/10722/167833-
dc.description.abstractThe interactions between a series of platinum complexes, including (pyridyl)(6-phenyl-2,2′-bipyridine) platinum(II) hexafluorophosphate (1), three dinuclear bis[(6-phenyl-2,2′-bipyridine)platinum(II)] complexes (2-4), and (4-aminopyridine)(4,6-diphenyl-2,2′-bipyridine)platinum(II) perchlorate (5) with DNA have been investigated. All Pt(II) complexes, except 5, were demonstrated to be DNA intercalators, based on viscosity measurements. Absorption and fluorescence titration results indicated that the addition of a phenyl ring to the 6-phenyl-2,2′-bipyridine ligand dramatically reduced the DNA binding of the Pt(II) complex 5. The dinuclear complexes 2-4 exhibited multiple binding modes of mono/bisintercalation and groove binding, as revealed by viscosity and fluorescence titration measurements. While complexes 2-4 bound to DNA with significantly enhanced affinities as compared to 1, compounds 1 and 2-4 showed similar IC50 values against a panel of cancer cell lines. In addition, these complexes showed similar cellular uptakes. The results indicated that the cytotoxicity of these (6-phenyl-2,2′ -bipyridine)platinum compounds may not be mediated through DNA binding but may involve interacting mechanisms with cellular components other than DNA.en_US
dc.languageengen_US
dc.publisherSpringer Verlag. The Journal's web site is located at http://link.springer.de/link/service/journals/00775/index.htmen_US
dc.relation.ispartofJournal of Biological Inorganic Chemistryen_US
dc.subject.meshAntineoplastic Agents - Chemical Synthesis - Pharmacologyen_US
dc.subject.meshCell Line, Tumoren_US
dc.subject.meshDna - Chemistry - Metabolismen_US
dc.subject.meshDrug Screening Assays, Antitumoren_US
dc.subject.meshHumansen_US
dc.subject.meshIntercalating Agents - Chemical Synthesis - Pharmacologyen_US
dc.subject.meshNucleic Acid Conformation - Drug Effectsen_US
dc.subject.meshOrganoplatinum Compounds - Chemical Synthesis - Pharmacologyen_US
dc.subject.meshPyridines - Chemical Synthesis - Pharmacologyen_US
dc.subject.meshSpectrum Analysisen_US
dc.subject.meshStructure-Activity Relationshipen_US
dc.titleBis-intercalative dinuclear platinum(II) 6-phenyl-2,2′-bipyridine complexes exhibit enhanced DNA affinity but similar cytotoxicity compared to the mononuclear uniten_US
dc.typeArticleen_US
dc.identifier.emailMa, DL:edmondma@hku.hken_US
dc.identifier.emailChe, CM:cmche@hku.hken_US
dc.identifier.authorityMa, DL=rp00760en_US
dc.identifier.authorityChe, CM=rp00670en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1007/s00775-003-0477-0en_US
dc.identifier.pmid12884091-
dc.identifier.scopuseid_2-s2.0-0141567650en_US
dc.identifier.hkuros94122-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0141567650&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume8en_US
dc.identifier.issue7en_US
dc.identifier.spage761en_US
dc.identifier.epage769en_US
dc.identifier.isiWOS:000185413100010-
dc.publisher.placeGermanyen_US
dc.identifier.scopusauthoridChan, HL=7403402315en_US
dc.identifier.scopusauthoridMa, DL=7402075538en_US
dc.identifier.scopusauthoridYang, M=35204210300en_US
dc.identifier.scopusauthoridChe, CM=7102442791en_US

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