File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: β2,2-aminoxy acids: A new building block for turns and helices

Titleβ2,2-aminoxy acids: A new building block for turns and helices
Authors
Issue Date2002
PublisherAmerican Chemical Society. The Journal's web site is located at http://pubs.acs.org/journals/jacsat/index.html
Citation
Journal Of The American Chemical Society, 2002, v. 124 n. 34, p. 9966-9967 How to Cite?
AbstractThe conformational properties of peptides 1-4 built from 3-aminoxy-2,2-dimethyl-propionic acid, a β2,2-aminoxy acid, were investigated by NMR spectroscopy and X-ray crystallography. A novel β N-O turn involving a nine-membered-ring intramolecular hydrogen bond between NHi+2 and COi was formed in diamides 1 and 2, which was further stabilized by another six-membered-ring intramolecular hydrogen bond between NHi+2 and NOi+1. Triamides 3 and 4 displayed a well-defined helical structure featuring two consecutive β N-O turns. The X-ray structure of 4 revealed that the amide carbonyl group at position i+2 was twisted +65.9° from that at i position, suggesting a novel 1.79 helix. Therefore, β2,2-aminoxy acid can be used as a new building block for turns and helices. Copyright © 2002 American Chemical Society.
Persistent Identifierhttp://hdl.handle.net/10722/167772
ISSN
2015 Impact Factor: 13.038
2015 SCImago Journal Rankings: 7.123
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorYang, Den_HK
dc.contributor.authorZhang, YHen_HK
dc.contributor.authorZhu, NYen_HK
dc.date.accessioned2012-10-08T03:11:22Z-
dc.date.available2012-10-08T03:11:22Z-
dc.date.issued2002en_HK
dc.identifier.citationJournal Of The American Chemical Society, 2002, v. 124 n. 34, p. 9966-9967en_HK
dc.identifier.issn0002-7863en_HK
dc.identifier.urihttp://hdl.handle.net/10722/167772-
dc.description.abstractThe conformational properties of peptides 1-4 built from 3-aminoxy-2,2-dimethyl-propionic acid, a β2,2-aminoxy acid, were investigated by NMR spectroscopy and X-ray crystallography. A novel β N-O turn involving a nine-membered-ring intramolecular hydrogen bond between NHi+2 and COi was formed in diamides 1 and 2, which was further stabilized by another six-membered-ring intramolecular hydrogen bond between NHi+2 and NOi+1. Triamides 3 and 4 displayed a well-defined helical structure featuring two consecutive β N-O turns. The X-ray structure of 4 revealed that the amide carbonyl group at position i+2 was twisted +65.9° from that at i position, suggesting a novel 1.79 helix. Therefore, β2,2-aminoxy acid can be used as a new building block for turns and helices. Copyright © 2002 American Chemical Society.en_HK
dc.languageengen_US
dc.publisherAmerican Chemical Society. The Journal's web site is located at http://pubs.acs.org/journals/jacsat/index.htmlen_HK
dc.relation.ispartofJournal of the American Chemical Societyen_HK
dc.subject.meshAmides - Chemical Synthesis - Chemistryen_US
dc.subject.meshModels, Molecularen_US
dc.subject.meshNuclear Magnetic Resonance, Biomolecularen_US
dc.subject.meshPeptides - Chemical Synthesis - Chemistryen_US
dc.subject.meshPropionic Acids - Chemistryen_US
dc.subject.meshProtein Structure, Secondaryen_US
dc.titleβ2,2-aminoxy acids: A new building block for turns and helicesen_HK
dc.typeArticleen_HK
dc.identifier.emailYang, D: yangdan@hku.hken_HK
dc.identifier.emailZhu, NY: nzhu@hkucc.hku.hken_HK
dc.identifier.authorityYang, D=rp00825en_HK
dc.identifier.authorityZhu, NY=rp00845en_HK
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1021/ja026966nen_HK
dc.identifier.pmid12188642-
dc.identifier.scopuseid_2-s2.0-0037189888en_HK
dc.identifier.hkuros75913-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0037189888&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume124en_HK
dc.identifier.issue34en_HK
dc.identifier.spage9966en_HK
dc.identifier.epage9967en_HK
dc.identifier.isiWOS:000177576000004-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridYang, D=7404800756en_HK
dc.identifier.scopusauthoridZhang, YH=8379010100en_HK
dc.identifier.scopusauthoridZhu, NY=7201449530en_HK

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats