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- Publisher Website: 10.1021/ja026966n
- Scopus: eid_2-s2.0-0037189888
- PMID: 12188642
- WOS: WOS:000177576000004
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Article: β2,2-aminoxy acids: A new building block for turns and helices
Title | β2,2-aminoxy acids: A new building block for turns and helices |
---|---|
Authors | |
Issue Date | 2002 |
Publisher | American Chemical Society. The Journal's web site is located at http://pubs.acs.org/journals/jacsat/index.html |
Citation | Journal Of The American Chemical Society, 2002, v. 124 n. 34, p. 9966-9967 How to Cite? |
Abstract | The conformational properties of peptides 1-4 built from 3-aminoxy-2,2-dimethyl-propionic acid, a β2,2-aminoxy acid, were investigated by NMR spectroscopy and X-ray crystallography. A novel β N-O turn involving a nine-membered-ring intramolecular hydrogen bond between NHi+2 and COi was formed in diamides 1 and 2, which was further stabilized by another six-membered-ring intramolecular hydrogen bond between NHi+2 and NOi+1. Triamides 3 and 4 displayed a well-defined helical structure featuring two consecutive β N-O turns. The X-ray structure of 4 revealed that the amide carbonyl group at position i+2 was twisted +65.9° from that at i position, suggesting a novel 1.79 helix. Therefore, β2,2-aminoxy acid can be used as a new building block for turns and helices. Copyright © 2002 American Chemical Society. |
Persistent Identifier | http://hdl.handle.net/10722/167772 |
ISSN | 2023 Impact Factor: 14.4 2023 SCImago Journal Rankings: 5.489 |
ISI Accession Number ID | |
References |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Yang, D | en_HK |
dc.contributor.author | Zhang, YH | en_HK |
dc.contributor.author | Zhu, NY | en_HK |
dc.date.accessioned | 2012-10-08T03:11:22Z | - |
dc.date.available | 2012-10-08T03:11:22Z | - |
dc.date.issued | 2002 | en_HK |
dc.identifier.citation | Journal Of The American Chemical Society, 2002, v. 124 n. 34, p. 9966-9967 | en_HK |
dc.identifier.issn | 0002-7863 | en_HK |
dc.identifier.uri | http://hdl.handle.net/10722/167772 | - |
dc.description.abstract | The conformational properties of peptides 1-4 built from 3-aminoxy-2,2-dimethyl-propionic acid, a β2,2-aminoxy acid, were investigated by NMR spectroscopy and X-ray crystallography. A novel β N-O turn involving a nine-membered-ring intramolecular hydrogen bond between NHi+2 and COi was formed in diamides 1 and 2, which was further stabilized by another six-membered-ring intramolecular hydrogen bond between NHi+2 and NOi+1. Triamides 3 and 4 displayed a well-defined helical structure featuring two consecutive β N-O turns. The X-ray structure of 4 revealed that the amide carbonyl group at position i+2 was twisted +65.9° from that at i position, suggesting a novel 1.79 helix. Therefore, β2,2-aminoxy acid can be used as a new building block for turns and helices. Copyright © 2002 American Chemical Society. | en_HK |
dc.language | eng | en_US |
dc.publisher | American Chemical Society. The Journal's web site is located at http://pubs.acs.org/journals/jacsat/index.html | en_HK |
dc.relation.ispartof | Journal of the American Chemical Society | en_HK |
dc.subject.mesh | Amides - Chemical Synthesis - Chemistry | en_US |
dc.subject.mesh | Models, Molecular | en_US |
dc.subject.mesh | Nuclear Magnetic Resonance, Biomolecular | en_US |
dc.subject.mesh | Peptides - Chemical Synthesis - Chemistry | en_US |
dc.subject.mesh | Propionic Acids - Chemistry | en_US |
dc.subject.mesh | Protein Structure, Secondary | en_US |
dc.title | β2,2-aminoxy acids: A new building block for turns and helices | en_HK |
dc.type | Article | en_HK |
dc.identifier.email | Yang, D: yangdan@hku.hk | en_HK |
dc.identifier.email | Zhu, NY: nzhu@hkucc.hku.hk | en_HK |
dc.identifier.authority | Yang, D=rp00825 | en_HK |
dc.identifier.authority | Zhu, NY=rp00845 | en_HK |
dc.description.nature | link_to_subscribed_fulltext | en_US |
dc.identifier.doi | 10.1021/ja026966n | en_HK |
dc.identifier.pmid | 12188642 | - |
dc.identifier.scopus | eid_2-s2.0-0037189888 | en_HK |
dc.identifier.hkuros | 75913 | - |
dc.relation.references | http://www.scopus.com/mlt/select.url?eid=2-s2.0-0037189888&selection=ref&src=s&origin=recordpage | en_HK |
dc.identifier.volume | 124 | en_HK |
dc.identifier.issue | 34 | en_HK |
dc.identifier.spage | 9966 | en_HK |
dc.identifier.epage | 9967 | en_HK |
dc.identifier.isi | WOS:000177576000004 | - |
dc.publisher.place | United States | en_HK |
dc.identifier.scopusauthorid | Yang, D=7404800756 | en_HK |
dc.identifier.scopusauthorid | Zhang, YH=8379010100 | en_HK |
dc.identifier.scopusauthorid | Zhu, NY=7201449530 | en_HK |
dc.identifier.issnl | 0002-7863 | - |