File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Biodegradable polylactide/poly(ethylene glycol)/polylactide triblock copolymer micelles as anticancer drug carriers

TitleBiodegradable polylactide/poly(ethylene glycol)/polylactide triblock copolymer micelles as anticancer drug carriers
Authors
KeywordsBiodegradable
Drug Delivery
Micelles
Poly(Ethylene Glycol)
Polylactide
Issue Date2001
PublisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www.interscience.wiley.com/jpages/0021-8995/
Citation
Journal Of Applied Polymer Science, 2001, v. 80 n. 11, p. 1976-1982 How to Cite?
AbstractAdriamycin (ADR) was selected as a model drug to evaluate the potential applications of polylactide/poly(ethylene glycol)/polylactide (PLA/PEG/PLA) micelles as drug carriers in parenteral delivery systems. The PLA/PEG/PLA triblock copolymer micelles were characterized by dynamic light scattering and transmission electron microscopy. It was found that the micelle size increased with the increasing of the PLA chain length. The average size of ADR-loaded micelles was 143.2 nm. The histogram analysis showed that the ADR-loaded micelles possessed a narrow unimodal size distribution. The ADR loading contents of the micelles and ADR entrapment efficiency were dependent on the PLA chain length and PEG chain length in the copolymer. They increased with the increase of the PLA chain length, but the PEG chain length was identical and decreased with the increase of the PEG chain length; the length of the PLA block was similar. The initial amount of ADR also influenced the drug contents and entrapment efficiency (i.e., the more the initial amount added, the more the drug contents and the higher encapsulation efficiency). The drug release experiments indicated that the ADR-loaded micelles possessed sustained release characteristics. © 2001 John Wiley & Sons, Inc.
Persistent Identifierhttp://hdl.handle.net/10722/167706
ISSN
2015 Impact Factor: 1.866
2015 SCImago Journal Rankings: 0.578
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorLiu, Len_US
dc.contributor.authorLi, Cen_US
dc.contributor.authorLi, Xen_US
dc.contributor.authorYuan, Zen_US
dc.contributor.authorAn, Yen_US
dc.contributor.authorHe, Ben_US
dc.date.accessioned2012-10-08T03:10:16Z-
dc.date.available2012-10-08T03:10:16Z-
dc.date.issued2001en_US
dc.identifier.citationJournal Of Applied Polymer Science, 2001, v. 80 n. 11, p. 1976-1982en_US
dc.identifier.issn0021-8995en_US
dc.identifier.urihttp://hdl.handle.net/10722/167706-
dc.description.abstractAdriamycin (ADR) was selected as a model drug to evaluate the potential applications of polylactide/poly(ethylene glycol)/polylactide (PLA/PEG/PLA) micelles as drug carriers in parenteral delivery systems. The PLA/PEG/PLA triblock copolymer micelles were characterized by dynamic light scattering and transmission electron microscopy. It was found that the micelle size increased with the increasing of the PLA chain length. The average size of ADR-loaded micelles was 143.2 nm. The histogram analysis showed that the ADR-loaded micelles possessed a narrow unimodal size distribution. The ADR loading contents of the micelles and ADR entrapment efficiency were dependent on the PLA chain length and PEG chain length in the copolymer. They increased with the increase of the PLA chain length, but the PEG chain length was identical and decreased with the increase of the PEG chain length; the length of the PLA block was similar. The initial amount of ADR also influenced the drug contents and entrapment efficiency (i.e., the more the initial amount added, the more the drug contents and the higher encapsulation efficiency). The drug release experiments indicated that the ADR-loaded micelles possessed sustained release characteristics. © 2001 John Wiley & Sons, Inc.en_US
dc.languageengen_US
dc.publisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www.interscience.wiley.com/jpages/0021-8995/en_US
dc.relation.ispartofJournal of Applied Polymer Scienceen_US
dc.subjectBiodegradableen_US
dc.subjectDrug Deliveryen_US
dc.subjectMicellesen_US
dc.subjectPoly(Ethylene Glycol)en_US
dc.subjectPolylactideen_US
dc.titleBiodegradable polylactide/poly(ethylene glycol)/polylactide triblock copolymer micelles as anticancer drug carriersen_US
dc.typeArticleen_US
dc.identifier.emailLi, X:xuechenl@hku.hken_US
dc.identifier.authorityLi, X=rp00742en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1002/app.1295en_US
dc.identifier.scopuseid_2-s2.0-0035854139en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0035854139&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume80en_US
dc.identifier.issue11en_US
dc.identifier.spage1976en_US
dc.identifier.epage1982en_US
dc.identifier.isiWOS:000167791800013-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridLiu, L=36068379000en_US
dc.identifier.scopusauthoridLi, C=8931261400en_US
dc.identifier.scopusauthoridLi, X=24168958800en_US
dc.identifier.scopusauthoridYuan, Z=7401477133en_US
dc.identifier.scopusauthoridAn, Y=7102051164en_US
dc.identifier.scopusauthoridHe, B=7402047951en_US

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats