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Article: Synthesis of 9Z, 11E-octadecadienoic and 10E, 12Z-octadecadienoic acids, the major components of conjugated linoleic acid

TitleSynthesis of 9Z, 11E-octadecadienoic and 10E, 12Z-octadecadienoic acids, the major components of conjugated linoleic acid
Authors
Issue Date1999
PublisherAOCS Press. The Journal's web site is located at http://www.aocs.org/press/lipids.htm
Citation
Lipids, 1999, v. 34 n. 8, p. 879-884 How to Cite?
AbstractLinoleic acid was efficiently converted into the two major components of conjugated linoleic acid, 9Z, 11 E-octadecadienoic (1a) and 10E, 12Z- octadecadienoic acid (1b) using either the superbase (n- butyllithium/potassium tert-butoxide) or by simply refluxing with KOH in 1- butanol. In turn, 1a and 1b were separated from each other using the lipase from Aspergillus niger via stereoselective esterification in 1-butanol. This enzyme has a preference for the 9Z, 11E isomer, 1a, and has excellent selectivity. This method has allowed the ready preparation of gram quantities of 1a and 1b in their highly purified forms, which are not readily accessible by current methods.
Persistent Identifierhttp://hdl.handle.net/10722/167613
ISSN
2015 Impact Factor: 1.892
2015 SCImago Journal Rankings: 0.795
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorChen, CAen_US
dc.contributor.authorLu, Wen_US
dc.contributor.authorSih, CJen_US
dc.date.accessioned2012-10-08T03:09:04Z-
dc.date.available2012-10-08T03:09:04Z-
dc.date.issued1999en_US
dc.identifier.citationLipids, 1999, v. 34 n. 8, p. 879-884en_US
dc.identifier.issn0024-4201en_US
dc.identifier.urihttp://hdl.handle.net/10722/167613-
dc.description.abstractLinoleic acid was efficiently converted into the two major components of conjugated linoleic acid, 9Z, 11 E-octadecadienoic (1a) and 10E, 12Z- octadecadienoic acid (1b) using either the superbase (n- butyllithium/potassium tert-butoxide) or by simply refluxing with KOH in 1- butanol. In turn, 1a and 1b were separated from each other using the lipase from Aspergillus niger via stereoselective esterification in 1-butanol. This enzyme has a preference for the 9Z, 11E isomer, 1a, and has excellent selectivity. This method has allowed the ready preparation of gram quantities of 1a and 1b in their highly purified forms, which are not readily accessible by current methods.en_US
dc.languageengen_US
dc.publisherAOCS Press. The Journal's web site is located at http://www.aocs.org/press/lipids.htmen_US
dc.relation.ispartofLipidsen_US
dc.subject.meshAnimalsen_US
dc.subject.meshCattleen_US
dc.subject.meshChromatography, High Pressure Liquiden_US
dc.subject.meshFatty Acids, Unsaturated - Chemical Synthesis - Isolation & Purificationen_US
dc.subject.meshLinoleic Acids - Chemistryen_US
dc.subject.meshLipaseen_US
dc.subject.meshMeat - Analysisen_US
dc.subject.meshMethodsen_US
dc.subject.meshStereoisomerismen_US
dc.titleSynthesis of 9Z, 11E-octadecadienoic and 10E, 12Z-octadecadienoic acids, the major components of conjugated linoleic aciden_US
dc.typeArticleen_US
dc.identifier.emailLu, W:luwei@hku.hken_US
dc.identifier.authorityLu, W=rp00754en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1007/s11745-999-0436-yen_US
dc.identifier.pmid10529100-
dc.identifier.scopuseid_2-s2.0-0032846440en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0032846440&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume34en_US
dc.identifier.issue8en_US
dc.identifier.spage879en_US
dc.identifier.epage884en_US
dc.identifier.isiWOS:000082583500014-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridChen, CA=7501962155en_US
dc.identifier.scopusauthoridLu, W=27868087600en_US
dc.identifier.scopusauthoridSih, CJ=7006959021en_US

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