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- Publisher Website: 10.1002/(SICI)1099-1344(199709)39:9<711::AID-JLCR22>3.0.CO;2-A
- Scopus: eid_2-s2.0-0030792003
- WOS: WOS:A1997XT70400001
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Article: Synthesis, attempted kinetic resolution and evaluation of [123I]-MK-447 analogues as inflammation radiopharmaceuticals
Title | Synthesis, attempted kinetic resolution and evaluation of [123I]-MK-447 analogues as inflammation radiopharmaceuticals |
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Authors | |
Keywords | [Mk-447]-Chiral Iron Complexes Inflammation Iodine-123 Kinetic Resolution Of Diastereoisomers Potential Radiopharmaceutical |
Issue Date | 1997 |
Publisher | John Wiley & Sons Ltd. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/3209 |
Citation | Journal Of Labelled Compounds And Radiopharmaceuticals, 1997, v. 39 n. 9, p. 711-729 How to Cite? |
Abstract | The non-steroidal anti-inflammatory agent 2-amino-methyl-4-tert-butyl-6-iodophenol hydrochloride (MK-447) and some of its analogues were labelled with 123I and tested in an inflamed rat-paw model. Even though MK-447 has a significant anti-inflammatory activity, and a 2.3 ratio for inflamed site over muscle, its usefullness for scintigraphic detection of inflammation is hindered by its high uptake in the skin. The kinetic resolution of diastereomeric products with chiral dienyl iron complexes was unsuccessful as the signals from the respective 1H and 13C NMR spectra were coincident. |
Persistent Identifier | http://hdl.handle.net/10722/167561 |
ISSN | 2023 Impact Factor: 0.9 2023 SCImago Journal Rankings: 0.326 |
ISI Accession Number ID | |
References |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Siu, AFM | en_US |
dc.contributor.author | Lambrecht, RM | en_US |
dc.contributor.author | Shani, J | en_US |
dc.contributor.author | Pyne, SG | en_US |
dc.contributor.author | KaneMaguire, LAP | en_US |
dc.date.accessioned | 2012-10-08T03:08:31Z | - |
dc.date.available | 2012-10-08T03:08:31Z | - |
dc.date.issued | 1997 | en_US |
dc.identifier.citation | Journal Of Labelled Compounds And Radiopharmaceuticals, 1997, v. 39 n. 9, p. 711-729 | en_US |
dc.identifier.issn | 0362-4803 | en_US |
dc.identifier.uri | http://hdl.handle.net/10722/167561 | - |
dc.description.abstract | The non-steroidal anti-inflammatory agent 2-amino-methyl-4-tert-butyl-6-iodophenol hydrochloride (MK-447) and some of its analogues were labelled with 123I and tested in an inflamed rat-paw model. Even though MK-447 has a significant anti-inflammatory activity, and a 2.3 ratio for inflamed site over muscle, its usefullness for scintigraphic detection of inflammation is hindered by its high uptake in the skin. The kinetic resolution of diastereomeric products with chiral dienyl iron complexes was unsuccessful as the signals from the respective 1H and 13C NMR spectra were coincident. | en_US |
dc.language | eng | en_US |
dc.publisher | John Wiley & Sons Ltd. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/3209 | en_US |
dc.relation.ispartof | Journal of Labelled Compounds and Radiopharmaceuticals | en_US |
dc.subject | [Mk-447]-Chiral Iron Complexes | en_US |
dc.subject | Inflammation | en_US |
dc.subject | Iodine-123 | en_US |
dc.subject | Kinetic Resolution Of Diastereoisomers | en_US |
dc.subject | Potential Radiopharmaceutical | en_US |
dc.title | Synthesis, attempted kinetic resolution and evaluation of [123I]-MK-447 analogues as inflammation radiopharmaceuticals | en_US |
dc.type | Article | en_US |
dc.identifier.email | Siu, AFM:fmsiu@hku.hk | en_US |
dc.identifier.authority | Siu, AFM=rp00776 | en_US |
dc.description.nature | link_to_subscribed_fulltext | en_US |
dc.identifier.doi | 10.1002/(SICI)1099-1344(199709)39:9<711::AID-JLCR22>3.0.CO;2-A | en_US |
dc.identifier.scopus | eid_2-s2.0-0030792003 | en_US |
dc.relation.references | http://www.scopus.com/mlt/select.url?eid=2-s2.0-0030792003&selection=ref&src=s&origin=recordpage | en_US |
dc.identifier.volume | 39 | en_US |
dc.identifier.issue | 9 | en_US |
dc.identifier.spage | 711 | en_US |
dc.identifier.epage | 729 | en_US |
dc.identifier.isi | WOS:A1997XT70400001 | - |
dc.publisher.place | United Kingdom | en_US |
dc.identifier.scopusauthorid | Siu, AFM=6701518489 | en_US |
dc.identifier.scopusauthorid | Lambrecht, RM=7102246483 | en_US |
dc.identifier.scopusauthorid | Shani, J=7101776018 | en_US |
dc.identifier.scopusauthorid | Pyne, SG=35496446700 | en_US |
dc.identifier.scopusauthorid | KaneMaguire, LAP=7003777750 | en_US |
dc.identifier.issnl | 0362-4803 | - |