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Article: Synthesis, attempted kinetic resolution and evaluation of [123I]-MK-447 analogues as inflammation radiopharmaceuticals

TitleSynthesis, attempted kinetic resolution and evaluation of [123I]-MK-447 analogues as inflammation radiopharmaceuticals
Authors
Keywords[Mk-447]-Chiral Iron Complexes
Inflammation
Iodine-123
Kinetic Resolution Of Diastereoisomers
Potential Radiopharmaceutical
Issue Date1997
PublisherJohn Wiley & Sons Ltd. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/3209
Citation
Journal Of Labelled Compounds And Radiopharmaceuticals, 1997, v. 39 n. 9, p. 711-729 How to Cite?
AbstractThe non-steroidal anti-inflammatory agent 2-amino-methyl-4-tert-butyl-6-iodophenol hydrochloride (MK-447) and some of its analogues were labelled with 123I and tested in an inflamed rat-paw model. Even though MK-447 has a significant anti-inflammatory activity, and a 2.3 ratio for inflamed site over muscle, its usefullness for scintigraphic detection of inflammation is hindered by its high uptake in the skin. The kinetic resolution of diastereomeric products with chiral dienyl iron complexes was unsuccessful as the signals from the respective 1H and 13C NMR spectra were coincident.
Persistent Identifierhttp://hdl.handle.net/10722/167561
ISSN
2015 Impact Factor: 1.532
2015 SCImago Journal Rankings: 0.468
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorSiu, AFMen_US
dc.contributor.authorLambrecht, RMen_US
dc.contributor.authorShani, Jen_US
dc.contributor.authorPyne, SGen_US
dc.contributor.authorKaneMaguire, LAPen_US
dc.date.accessioned2012-10-08T03:08:31Z-
dc.date.available2012-10-08T03:08:31Z-
dc.date.issued1997en_US
dc.identifier.citationJournal Of Labelled Compounds And Radiopharmaceuticals, 1997, v. 39 n. 9, p. 711-729en_US
dc.identifier.issn0362-4803en_US
dc.identifier.urihttp://hdl.handle.net/10722/167561-
dc.description.abstractThe non-steroidal anti-inflammatory agent 2-amino-methyl-4-tert-butyl-6-iodophenol hydrochloride (MK-447) and some of its analogues were labelled with 123I and tested in an inflamed rat-paw model. Even though MK-447 has a significant anti-inflammatory activity, and a 2.3 ratio for inflamed site over muscle, its usefullness for scintigraphic detection of inflammation is hindered by its high uptake in the skin. The kinetic resolution of diastereomeric products with chiral dienyl iron complexes was unsuccessful as the signals from the respective 1H and 13C NMR spectra were coincident.en_US
dc.languageengen_US
dc.publisherJohn Wiley & Sons Ltd. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/3209en_US
dc.relation.ispartofJournal of Labelled Compounds and Radiopharmaceuticalsen_US
dc.subject[Mk-447]-Chiral Iron Complexesen_US
dc.subjectInflammationen_US
dc.subjectIodine-123en_US
dc.subjectKinetic Resolution Of Diastereoisomersen_US
dc.subjectPotential Radiopharmaceuticalen_US
dc.titleSynthesis, attempted kinetic resolution and evaluation of [123I]-MK-447 analogues as inflammation radiopharmaceuticalsen_US
dc.typeArticleen_US
dc.identifier.emailSiu, AFM:fmsiu@hku.hken_US
dc.identifier.authoritySiu, AFM=rp00776en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1002/(SICI)1099-1344(199709)39:9<711::AID-JLCR22>3.0.CO;2-Aen_US
dc.identifier.scopuseid_2-s2.0-0030792003en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0030792003&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume39en_US
dc.identifier.issue9en_US
dc.identifier.spage711en_US
dc.identifier.epage729en_US
dc.identifier.isiWOS:A1997XT70400001-
dc.publisher.placeUnited Kingdomen_US
dc.identifier.scopusauthoridSiu, AFM=6701518489en_US
dc.identifier.scopusauthoridLambrecht, RM=7102246483en_US
dc.identifier.scopusauthoridShani, J=7101776018en_US
dc.identifier.scopusauthoridPyne, SG=35496446700en_US
dc.identifier.scopusauthoridKaneMaguire, LAP=7003777750en_US

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