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Article: Human Microsomal Triglyceride Transfer Protein large subunit gene structure

TitleHuman Microsomal Triglyceride Transfer Protein large subunit gene structure
Authors
Issue Date1994
PublisherAmerican Chemical Society. The Journal's web site is located at http://pubs.acs.org/biochemistry
Citation
Biochemistry, 1994, v. 33 n. 31, p. 9057-9061 How to Cite?
AbstractMicrosomal triglyceride transfer protein (MTP) is a heterodimer consisting of the multifunctional enzyme protein disulfide isomerase and a unique, large 97-kDa subunit. MTP is required for the assembly and secretion of very low density lipoproteins and chylomicrons by the liver and intestine, respectively. In vitro, MTP catalyzes the transport of triglyceride, cholesteryl ester, and phosphatidylcholine between phospholipid surfaces. We have characterized the gene encoding the large subunit of human MTP. It contains 18 exons and spans approximately 55-60 kb. Fluorescent in situ hybridization localized this gene to band 4q24 of chromosome 4. A (CA)n repeat polymorphic marker, which may be useful for investigating a link between the MTP gene and genetic defects in lipid metabolism, was identified in intron 10. Sequence analysis of the 5′ flanking region of the gene revealed potential sites which may bind transcriptional factors and control MTP expression. © 1994 American Chemical Society.
Persistent Identifierhttp://hdl.handle.net/10722/167516
ISSN
2015 Impact Factor: 2.876
2015 SCImago Journal Rankings: 1.769
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorSharp, Den_US
dc.contributor.authorRicci, Ben_US
dc.contributor.authorKienzle, Ben_US
dc.contributor.authorLin, MCMen_US
dc.contributor.authorWetterau, JRen_US
dc.date.accessioned2012-10-08T03:07:57Z-
dc.date.available2012-10-08T03:07:57Z-
dc.date.issued1994en_US
dc.identifier.citationBiochemistry, 1994, v. 33 n. 31, p. 9057-9061en_US
dc.identifier.issn0006-2960en_US
dc.identifier.urihttp://hdl.handle.net/10722/167516-
dc.description.abstractMicrosomal triglyceride transfer protein (MTP) is a heterodimer consisting of the multifunctional enzyme protein disulfide isomerase and a unique, large 97-kDa subunit. MTP is required for the assembly and secretion of very low density lipoproteins and chylomicrons by the liver and intestine, respectively. In vitro, MTP catalyzes the transport of triglyceride, cholesteryl ester, and phosphatidylcholine between phospholipid surfaces. We have characterized the gene encoding the large subunit of human MTP. It contains 18 exons and spans approximately 55-60 kb. Fluorescent in situ hybridization localized this gene to band 4q24 of chromosome 4. A (CA)n repeat polymorphic marker, which may be useful for investigating a link between the MTP gene and genetic defects in lipid metabolism, was identified in intron 10. Sequence analysis of the 5′ flanking region of the gene revealed potential sites which may bind transcriptional factors and control MTP expression. © 1994 American Chemical Society.en_US
dc.languageengen_US
dc.publisherAmerican Chemical Society. The Journal's web site is located at http://pubs.acs.org/biochemistryen_US
dc.relation.ispartofBiochemistryen_US
dc.subject.meshAllelesen_US
dc.subject.meshAnimalsen_US
dc.subject.meshApolipoproteins - Biosynthesisen_US
dc.subject.meshBase Sequenceen_US
dc.subject.meshCarrier Proteins - Geneticsen_US
dc.subject.meshCattleen_US
dc.subject.meshCholesterol Ester Transfer Proteinsen_US
dc.subject.meshChromosomes, Human, Pair 4en_US
dc.subject.meshDna, Satellite - Geneticsen_US
dc.subject.meshExonsen_US
dc.subject.meshGenetic Variationen_US
dc.subject.meshGenomic Libraryen_US
dc.subject.meshGlycoproteinsen_US
dc.subject.meshHominidae - Geneticsen_US
dc.subject.meshHumansen_US
dc.subject.meshIn Situ Hybridization, Fluorescenceen_US
dc.subject.meshIntronsen_US
dc.subject.meshMacromolecular Substancesen_US
dc.subject.meshMicrosomes - Enzymologyen_US
dc.subject.meshMolecular Sequence Dataen_US
dc.subject.meshPolymorphism, Restriction Fragment Lengthen_US
dc.subject.meshRestriction Mappingen_US
dc.titleHuman Microsomal Triglyceride Transfer Protein large subunit gene structureen_US
dc.typeArticleen_US
dc.identifier.emailLin, MCM:mcllin@hkucc.hku.hken_US
dc.identifier.authorityLin, MCM=rp00746en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1021/bi00197a005-
dc.identifier.pmid7545943-
dc.identifier.scopuseid_2-s2.0-0028022939en_US
dc.identifier.volume33en_US
dc.identifier.issue31en_US
dc.identifier.spage9057en_US
dc.identifier.epage9061en_US
dc.identifier.isiWOS:A1994PB76300005-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridSharp, D=36899656600en_US
dc.identifier.scopusauthoridRicci, B=7005945097en_US
dc.identifier.scopusauthoridKienzle, B=6603360124en_US
dc.identifier.scopusauthoridLin, MCM=7404816359en_US
dc.identifier.scopusauthoridWetterau, JR=7003768777en_US

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