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Article: Loss and restoration of glucagon receptors and responsiveness in a transformed kidney cell line

TitleLoss and restoration of glucagon receptors and responsiveness in a transformed kidney cell line
Authors
Issue Date1982
PublisherAcademic Press. The Journal's web site is located at http://www.elsevier.com/locate/yexcr
Citation
Experimental Cell Research, 1982, v. 142 n. 1, p. 181-189 How to Cite?
AbstractA kidney cell line (MDCK) retains an adenylate cyclase system sensitive to glucagon, vasopressin, isoproterenol and prostaglandin E1. The stimulatory effect of glucagon on cAMP production was selectively lost in a cloned line derived from MDCK cells transformed by Harvey murine sarcoma virus. Sensitivity to glucagon was largely restored by treatment of the transformed cells with prostaglandin E1 or butyrate. Loss and reappearance of glucagon receptors seemed to be responsible for the observation. The parental MDCK line produced prostaglandins and in the transformed line, this function was abolished. These observations suggest that synthesis of glucagon receptors is controlled by endogenously produced prostaglandin in MDCK cells and that loss of glucagon receptors and their responsiveness in the transformed cells occurs as a consequence of the inability of these cells to synthesize this prostaglandin.
Persistent Identifierhttp://hdl.handle.net/10722/167455
ISSN
2015 Impact Factor: 3.378
2015 SCImago Journal Rankings: 1.900
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorLin, MCen_US
dc.contributor.authorKoh, SWMen_US
dc.contributor.authorDykman, DDen_US
dc.date.accessioned2012-10-08T03:07:13Z-
dc.date.available2012-10-08T03:07:13Z-
dc.date.issued1982en_US
dc.identifier.citationExperimental Cell Research, 1982, v. 142 n. 1, p. 181-189en_US
dc.identifier.issn0014-4827en_US
dc.identifier.urihttp://hdl.handle.net/10722/167455-
dc.description.abstractA kidney cell line (MDCK) retains an adenylate cyclase system sensitive to glucagon, vasopressin, isoproterenol and prostaglandin E1. The stimulatory effect of glucagon on cAMP production was selectively lost in a cloned line derived from MDCK cells transformed by Harvey murine sarcoma virus. Sensitivity to glucagon was largely restored by treatment of the transformed cells with prostaglandin E1 or butyrate. Loss and reappearance of glucagon receptors seemed to be responsible for the observation. The parental MDCK line produced prostaglandins and in the transformed line, this function was abolished. These observations suggest that synthesis of glucagon receptors is controlled by endogenously produced prostaglandin in MDCK cells and that loss of glucagon receptors and their responsiveness in the transformed cells occurs as a consequence of the inability of these cells to synthesize this prostaglandin.-
dc.languageengen_US
dc.publisherAcademic Press. The Journal's web site is located at http://www.elsevier.com/locate/yexcren_US
dc.relation.ispartofExperimental Cell Researchen_US
dc.subject.meshAnimalsen_US
dc.subject.meshButyric Acids - Pharmacologyen_US
dc.subject.meshCell Lineen_US
dc.subject.meshCell Membrane - Metabolismen_US
dc.subject.meshCell Transformation, Viralen_US
dc.subject.meshCyclic Amp - Biosynthesisen_US
dc.subject.meshDogsen_US
dc.subject.meshKidneyen_US
dc.subject.meshProstaglandins E - Metabolism - Pharmacologyen_US
dc.subject.meshProstaglandins F - Metabolismen_US
dc.subject.meshReceptors, Cell Surface - Metabolismen_US
dc.subject.meshReceptors, Glucagonen_US
dc.subject.meshSarcoma Viruses, Murineen_US
dc.titleLoss and restoration of glucagon receptors and responsiveness in a transformed kidney cell lineen_US
dc.typeArticleen_US
dc.identifier.emailLin, MC:mcllin@hkucc.hku.hken_US
dc.identifier.authorityLin, MC=rp00746en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/0014-4827(82)90421-9-
dc.identifier.pmid6291963-
dc.identifier.scopuseid_2-s2.0-0020446420en_US
dc.identifier.volume142en_US
dc.identifier.issue1en_US
dc.identifier.spage181en_US
dc.identifier.epage189en_US
dc.identifier.isiWOS:A1982PS24800020-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridLin, MC=7404816359en_US
dc.identifier.scopusauthoridKoh, SWM=7202062547en_US
dc.identifier.scopusauthoridDykman, DD=55300521600en_US

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