File Download
  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Reduction of GTP activation of adenylate cyclase system by its coupling to hormone receptor

TitleReduction of GTP activation of adenylate cyclase system by its coupling to hormone receptor
Authors
Issue Date1979
PublisherAmerican Society for Biochemistry and Molecular Biology, Inc. The Journal's web site is located at http://www.jbc.org/
Citation
Journal Of Biological Chemistry, 1979, v. 254 n. 11, p. 4684-4688 How to Cite?
AbstractWe have examined the characteristics of the adenylate cyclase system from control and butyrate-treated cells. Butyrate treatment results in both an increased number of catecholamine receptors and an induction of a response to the hormone, as reported previously (Tallman, J. F. Smith, C. C., and Henneberry, R. C. (1977) Proc. Natl. Acad. Sci. U. S. A. 74, 873-877); in addition, we found that the same treatment reduces the degree of activation of adenylate cyclase by GTP. We have demonstrated in two cell types that this decrease in GTP activation is inversely related to the degree of induction of the hormone response. Furthermore, in plasma membranes isolated from butyrate-treated cells, the hormone receptor is sensitive to GTP; i.e. GTP reduces the affinity of isoproterenol for the receptor. We propose that these changes reflect an interaction between the β-adrenergic receptor and the nucleotide regulatory component and that this interaction represents, at least in part, the process of coupling. Several possible mechanisms which can account for the change in GTP activation are discussed in terms of our current understanding of the regulation of the adenylate cyclase system.
Persistent Identifierhttp://hdl.handle.net/10722/167448
ISSN
2015 Impact Factor: 4.258
2015 SCImago Journal Rankings: 3.151
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorLin, MCen_US
dc.contributor.authorLin, Cen_US
dc.contributor.authorWhitlock Jr, JPen_US
dc.date.accessioned2012-10-08T03:07:08Z-
dc.date.available2012-10-08T03:07:08Z-
dc.date.issued1979en_US
dc.identifier.citationJournal Of Biological Chemistry, 1979, v. 254 n. 11, p. 4684-4688en_US
dc.identifier.issn0021-9258en_US
dc.identifier.urihttp://hdl.handle.net/10722/167448-
dc.description.abstractWe have examined the characteristics of the adenylate cyclase system from control and butyrate-treated cells. Butyrate treatment results in both an increased number of catecholamine receptors and an induction of a response to the hormone, as reported previously (Tallman, J. F. Smith, C. C., and Henneberry, R. C. (1977) Proc. Natl. Acad. Sci. U. S. A. 74, 873-877); in addition, we found that the same treatment reduces the degree of activation of adenylate cyclase by GTP. We have demonstrated in two cell types that this decrease in GTP activation is inversely related to the degree of induction of the hormone response. Furthermore, in plasma membranes isolated from butyrate-treated cells, the hormone receptor is sensitive to GTP; i.e. GTP reduces the affinity of isoproterenol for the receptor. We propose that these changes reflect an interaction between the β-adrenergic receptor and the nucleotide regulatory component and that this interaction represents, at least in part, the process of coupling. Several possible mechanisms which can account for the change in GTP activation are discussed in terms of our current understanding of the regulation of the adenylate cyclase system.en_US
dc.languageengen_US
dc.publisherAmerican Society for Biochemistry and Molecular Biology, Inc. The Journal's web site is located at http://www.jbc.org/en_US
dc.relation.ispartofJournal of Biological Chemistryen_US
dc.subject.mesh1-Methyl-3-Isobutylxanthine - Pharmacologyen_US
dc.subject.meshAdenylate Cyclase - Metabolismen_US
dc.subject.meshButyrates - Pharmacologyen_US
dc.subject.meshCell Membrane - Drug Effects - Metabolismen_US
dc.subject.meshFluorides - Pharmacologyen_US
dc.subject.meshGuanosine Triphosphate - Pharmacologyen_US
dc.subject.meshGuanylyl Imidodiphosphate - Pharmacologyen_US
dc.subject.meshHela Cells - Drug Effects - Metabolismen_US
dc.subject.meshHumansen_US
dc.subject.meshIsoproterenol - Pharmacologyen_US
dc.subject.meshKineticsen_US
dc.subject.meshReceptors, Cyclic Amp - Drug Effects - Metabolismen_US
dc.titleReduction of GTP activation of adenylate cyclase system by its coupling to hormone receptoren_US
dc.typeArticleen_US
dc.identifier.emailLin, MC:mcllin@hkucc.hku.hken_US
dc.identifier.authorityLin, MC=rp00746en_US
dc.description.naturelink_to_OA_fulltexten_US
dc.identifier.pmid86543-
dc.identifier.scopuseid_2-s2.0-0018759456en_US
dc.identifier.volume254en_US
dc.identifier.issue11en_US
dc.identifier.spage4684en_US
dc.identifier.epage4688en_US
dc.identifier.isiWOS:A1979GZ30300064-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridLin, MC=7404816359en_US
dc.identifier.scopusauthoridLin, C=24540146100en_US
dc.identifier.scopusauthoridWhitlock Jr, JP=7102828708en_US

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats