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Article: The hepatic adenylate cyclase system. II. Substrate binding and utilization and the effects of magnesium ion and pH

TitleThe hepatic adenylate cyclase system. II. Substrate binding and utilization and the effects of magnesium ion and pH
Authors
Issue Date1975
PublisherAmerican Society for Biochemistry and Molecular Biology, Inc. The Journal's web site is located at http://www.jbc.org/
Citation
Journal Of Biological Chemistry, 1975, v. 250 n. 11, p. 4246-4252 How to Cite?
AbstractThe kinetic characteristics of substrate utilization by hepatic adenylate cyclase were investigated under a variety of incubation conditions, including variations in pH, [substrate], [Mg 2+], and in the absence or presence of glucagon. Activities were compared with ATP and 5' adenylylimidodiphosphate [App(NH)p] as substrates. The K(m) for both substrates was about 50 μM; V(max) given with App(NH)p was about 40% lower than obtained with ATP as substrate.
Persistent Identifierhttp://hdl.handle.net/10722/167435
ISSN
2015 Impact Factor: 4.258
2015 SCImago Journal Rankings: 3.151
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorLin, MCen_US
dc.contributor.authorSalomon, Yen_US
dc.contributor.authorRendell, Men_US
dc.contributor.authorRodbell, Men_US
dc.date.accessioned2012-10-08T03:06:57Z-
dc.date.available2012-10-08T03:06:57Z-
dc.date.issued1975en_US
dc.identifier.citationJournal Of Biological Chemistry, 1975, v. 250 n. 11, p. 4246-4252en_US
dc.identifier.issn0021-9258en_US
dc.identifier.urihttp://hdl.handle.net/10722/167435-
dc.description.abstractThe kinetic characteristics of substrate utilization by hepatic adenylate cyclase were investigated under a variety of incubation conditions, including variations in pH, [substrate], [Mg 2+], and in the absence or presence of glucagon. Activities were compared with ATP and 5' adenylylimidodiphosphate [App(NH)p] as substrates. The K(m) for both substrates was about 50 μM; V(max) given with App(NH)p was about 40% lower than obtained with ATP as substrate.en_US
dc.languageengen_US
dc.publisherAmerican Society for Biochemistry and Molecular Biology, Inc. The Journal's web site is located at http://www.jbc.org/en_US
dc.relation.ispartofJournal of Biological Chemistryen_US
dc.subject.meshAdenine Nucleotides - Pharmacologyen_US
dc.subject.meshAdenosine Triphosphate - Pharmacologyen_US
dc.subject.meshAdenylate Cyclase - Metabolismen_US
dc.subject.meshAnimalsen_US
dc.subject.meshBinding Sitesen_US
dc.subject.meshCell Membrane - Drug Effects - Enzymologyen_US
dc.subject.meshGlucagon - Pharmacologyen_US
dc.subject.meshHydrogen-Ion Concentrationen_US
dc.subject.meshImides - Pharmacologyen_US
dc.subject.meshKineticsen_US
dc.subject.meshLiver - Drug Effects - Enzymologyen_US
dc.subject.meshMagnesium - Pharmacologyen_US
dc.subject.meshProtein Bindingen_US
dc.subject.meshRatsen_US
dc.titleThe hepatic adenylate cyclase system. II. Substrate binding and utilization and the effects of magnesium ion and pHen_US
dc.typeArticleen_US
dc.identifier.emailLin, MC:mcllin@hkucc.hku.hken_US
dc.identifier.authorityLin, MC=rp00746en_US
dc.description.naturelink_to_OA_fulltexten_US
dc.identifier.pmid236315-
dc.identifier.scopuseid_2-s2.0-0016745119en_US
dc.identifier.volume250en_US
dc.identifier.issue11en_US
dc.identifier.spage4246en_US
dc.identifier.epage4252en_US
dc.identifier.isiWOS:A1975AE57800030-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridLin, MC=7404816359en_US
dc.identifier.scopusauthoridSalomon, Y=7006956498en_US
dc.identifier.scopusauthoridRendell, M=7006683060en_US
dc.identifier.scopusauthoridRodbell, M=7006658086en_US

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