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- Scopus: eid_2-s2.0-0016745119
- PMID: 236315
- WOS: WOS:A1975AE57800030
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Article: The hepatic adenylate cyclase system. II. Substrate binding and utilization and the effects of magnesium ion and pH
Title | The hepatic adenylate cyclase system. II. Substrate binding and utilization and the effects of magnesium ion and pH |
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Authors | |
Issue Date | 1975 |
Publisher | American Society for Biochemistry and Molecular Biology, Inc. The Journal's web site is located at http://www.jbc.org/ |
Citation | Journal Of Biological Chemistry, 1975, v. 250 n. 11, p. 4246-4252 How to Cite? |
Abstract | The kinetic characteristics of substrate utilization by hepatic adenylate cyclase were investigated under a variety of incubation conditions, including variations in pH, [substrate], [Mg 2+], and in the absence or presence of glucagon. Activities were compared with ATP and 5' adenylylimidodiphosphate [App(NH)p] as substrates. The K(m) for both substrates was about 50 μM; V(max) given with App(NH)p was about 40% lower than obtained with ATP as substrate. |
Persistent Identifier | http://hdl.handle.net/10722/167435 |
ISSN | 2020 Impact Factor: 5.157 2023 SCImago Journal Rankings: 1.766 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Lin, MC | en_US |
dc.contributor.author | Salomon, Y | en_US |
dc.contributor.author | Rendell, M | en_US |
dc.contributor.author | Rodbell, M | en_US |
dc.date.accessioned | 2012-10-08T03:06:57Z | - |
dc.date.available | 2012-10-08T03:06:57Z | - |
dc.date.issued | 1975 | en_US |
dc.identifier.citation | Journal Of Biological Chemistry, 1975, v. 250 n. 11, p. 4246-4252 | en_US |
dc.identifier.issn | 0021-9258 | en_US |
dc.identifier.uri | http://hdl.handle.net/10722/167435 | - |
dc.description.abstract | The kinetic characteristics of substrate utilization by hepatic adenylate cyclase were investigated under a variety of incubation conditions, including variations in pH, [substrate], [Mg 2+], and in the absence or presence of glucagon. Activities were compared with ATP and 5' adenylylimidodiphosphate [App(NH)p] as substrates. The K(m) for both substrates was about 50 μM; V(max) given with App(NH)p was about 40% lower than obtained with ATP as substrate. | en_US |
dc.language | eng | en_US |
dc.publisher | American Society for Biochemistry and Molecular Biology, Inc. The Journal's web site is located at http://www.jbc.org/ | en_US |
dc.relation.ispartof | Journal of Biological Chemistry | en_US |
dc.subject.mesh | Adenine Nucleotides - Pharmacology | en_US |
dc.subject.mesh | Adenosine Triphosphate - Pharmacology | en_US |
dc.subject.mesh | Adenylate Cyclase - Metabolism | en_US |
dc.subject.mesh | Animals | en_US |
dc.subject.mesh | Binding Sites | en_US |
dc.subject.mesh | Cell Membrane - Drug Effects - Enzymology | en_US |
dc.subject.mesh | Glucagon - Pharmacology | en_US |
dc.subject.mesh | Hydrogen-Ion Concentration | en_US |
dc.subject.mesh | Imides - Pharmacology | en_US |
dc.subject.mesh | Kinetics | en_US |
dc.subject.mesh | Liver - Drug Effects - Enzymology | en_US |
dc.subject.mesh | Magnesium - Pharmacology | en_US |
dc.subject.mesh | Protein Binding | en_US |
dc.subject.mesh | Rats | en_US |
dc.title | The hepatic adenylate cyclase system. II. Substrate binding and utilization and the effects of magnesium ion and pH | en_US |
dc.type | Article | en_US |
dc.identifier.email | Lin, MC:mcllin@hkucc.hku.hk | en_US |
dc.identifier.authority | Lin, MC=rp00746 | en_US |
dc.description.nature | link_to_OA_fulltext | en_US |
dc.identifier.pmid | 236315 | - |
dc.identifier.scopus | eid_2-s2.0-0016745119 | en_US |
dc.identifier.volume | 250 | en_US |
dc.identifier.issue | 11 | en_US |
dc.identifier.spage | 4246 | en_US |
dc.identifier.epage | 4252 | en_US |
dc.identifier.isi | WOS:A1975AE57800030 | - |
dc.publisher.place | United States | en_US |
dc.identifier.scopusauthorid | Lin, MC=7404816359 | en_US |
dc.identifier.scopusauthorid | Salomon, Y=7006956498 | en_US |
dc.identifier.scopusauthorid | Rendell, M=7006683060 | en_US |
dc.identifier.scopusauthorid | Rodbell, M=7006658086 | en_US |
dc.identifier.issnl | 0021-9258 | - |