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Conference Paper: Non-invasive localization and quantification of graded ischemia using electromechanical wave imaging in vivo

TitleNon-invasive localization and quantification of graded ischemia using electromechanical wave imaging in vivo
Authors
KeywordsElectrical Mapping
Electromechanical Wave Imaging High Frame-Rate Echocardiography
Ischemia
Radio-Frequency Cross-Correlation
Issue Date2009
Citation
Proceedings - Ieee Ultrasonics Symposium, 2009 How to Cite?
AbstractElectromechanical Wave Imaging (EWI) has recently been introduced as a non-invasive, ultrasound-based imaging modality, which could map the electrical activation of the heart in various echocardiographic planes in mice, dogs and humans in vivo. By acquiring radio-frequency (RF) frames at very high frame rates (390-520Hz), the onset of small, localized, transient deformations resulting from the electrical activation of the heart, i.e., generating the electromechanical wave (EMW), can be mapped. The correlation between the EMW and the electrical activation speed and pacing scheme has previously been reported. In this study, we pursue the development of EWI and analysis of the EMW properties in dogs in vivo for early detection of ischemia. EWI was performed in normal and ischemic open-chested dogs during sinus rhythm. Ischemia of increasing severity was obtained by gradually occluding the left-anterior descending (LAD) coronary artery. EWI was shown to be sensitive to the presence of intermediate ischemia. EWI localized the ischemic region when the LAD was occluded at 60% and beyond and was capable of mapping the increase of the ischemic region size as the LAD occlusion level increased. Those results indicate that EWI could be used to assess electrical conduction properties of the myocardium, and detect ischemic onset and disease progression entirely non-invasively. ©2009 IEEE.
Persistent Identifierhttp://hdl.handle.net/10722/167113
ISSN
References

 

DC FieldValueLanguage
dc.contributor.authorProvost, Jen_US
dc.contributor.authorLee, WNen_US
dc.contributor.authorFujikura, Ken_US
dc.contributor.authorKonofagou, EEen_US
dc.date.accessioned2012-09-28T04:04:15Z-
dc.date.available2012-09-28T04:04:15Z-
dc.date.issued2009en_US
dc.identifier.citationProceedings - Ieee Ultrasonics Symposium, 2009en_US
dc.identifier.issn1051-0117en_US
dc.identifier.urihttp://hdl.handle.net/10722/167113-
dc.description.abstractElectromechanical Wave Imaging (EWI) has recently been introduced as a non-invasive, ultrasound-based imaging modality, which could map the electrical activation of the heart in various echocardiographic planes in mice, dogs and humans in vivo. By acquiring radio-frequency (RF) frames at very high frame rates (390-520Hz), the onset of small, localized, transient deformations resulting from the electrical activation of the heart, i.e., generating the electromechanical wave (EMW), can be mapped. The correlation between the EMW and the electrical activation speed and pacing scheme has previously been reported. In this study, we pursue the development of EWI and analysis of the EMW properties in dogs in vivo for early detection of ischemia. EWI was performed in normal and ischemic open-chested dogs during sinus rhythm. Ischemia of increasing severity was obtained by gradually occluding the left-anterior descending (LAD) coronary artery. EWI was shown to be sensitive to the presence of intermediate ischemia. EWI localized the ischemic region when the LAD was occluded at 60% and beyond and was capable of mapping the increase of the ischemic region size as the LAD occlusion level increased. Those results indicate that EWI could be used to assess electrical conduction properties of the myocardium, and detect ischemic onset and disease progression entirely non-invasively. ©2009 IEEE.en_US
dc.languageengen_US
dc.relation.ispartofProceedings - IEEE Ultrasonics Symposiumen_US
dc.subjectElectrical Mappingen_US
dc.subjectElectromechanical Wave Imaging High Frame-Rate Echocardiographyen_US
dc.subjectIschemiaen_US
dc.subjectRadio-Frequency Cross-Correlationen_US
dc.titleNon-invasive localization and quantification of graded ischemia using electromechanical wave imaging in vivoen_US
dc.typeConference_Paperen_US
dc.identifier.emailLee, WN: wnlee@hku.hken_US
dc.identifier.authorityLee, WN=rp01663en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1109/ULTSYM.2009.5441811en_US
dc.identifier.scopuseid_2-s2.0-77952803915en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-77952803915&selection=ref&src=s&origin=recordpageen_US
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridProvost, J=7103236841en_US
dc.identifier.scopusauthoridLee, WN=22634980600en_US
dc.identifier.scopusauthoridFujikura, K=7004375160en_US
dc.identifier.scopusauthoridKonofagou, EE=7005877325en_US

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