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Conference Paper: In vivo validation of 2D myocardial elastography at variable levels of ischemia

TitleIn vivo validation of 2D myocardial elastography at variable levels of ischemia
Authors
KeywordsAngle-Independent
Circumferential
Cross-Correlation
Elastography
Ischemia
Myocardial
Occlusion
Radial
Radiofrequency
Recorrelation
Strain
Issue Date2008
Citation
Proceedings - Ieee Ultrasonics Symposium, 2008, p. 962-965 How to Cite?
AbstractThe objective of this study is to validate twodimensional (2D) myocardial elastography estimates in canine hearts in vivo against direct sonomicrometry measurements at variable levels of myocardial ischemia induced by the occlusion of the left anterior descending (LAD) coronary artery. Twodimensional myocardial elastography comprised transmural: 1) 2D (lateral and axial) displacements using 1D cross-correlation in a 2D search and recorrelation (3.5 mm window size; 80% overlap); 2) 2D Lagrangian strain estimation using a leastsquared strain estimator; and 3) polar (radial and circumferential) strains through coordinate transformation. An Ultrasonix RP system with a 3.3 MHz phased array and 128 beams was used to acquire RF frames in a 2D short-axis view at the frame rate of 211 fps using an automatic composite technique previously developed by our group. A non-survival canine ischemic model was performed by inducing an occlusion of the LAD coronary artery, from 0% to 100% at a 20% increment. Two separate sets of four piezoelectric crystals (1 in the subepicardium; 1 in the sub-endocardium; 2 at the epicardium) in a tetrahedral configuration were placed in the ischemic (i.e., anterior) and normal (i.e., posterior) regions. Polar strains were calculated from the coordinates of the crystals. Reduced radial thickening or radial thinning at the occlusion level larger than 40% were observed based on strain estimates from both 2D myocardial elastography and sonomicrometry. Good agreement in radial strain between the two methods was found from the Bland-Altman analysis. These findings demonstrate that 2D myocardial elastography could serve as a powerful diagnostic tool to non-invasively detect, localize and identify the ischemic region at its very early stages, i.e., at 40% coronary artery occlusion. © 2008 IEEE.
Persistent Identifierhttp://hdl.handle.net/10722/167111
ISSN
References

 

DC FieldValueLanguage
dc.contributor.authorLee, WNen_US
dc.contributor.authorProvost, Jen_US
dc.contributor.authorWang, Sen_US
dc.contributor.authorFujikura, Ken_US
dc.contributor.authorWang, Jen_US
dc.contributor.authorKonofagou, EEen_US
dc.date.accessioned2012-09-28T04:04:14Z-
dc.date.available2012-09-28T04:04:14Z-
dc.date.issued2008en_US
dc.identifier.citationProceedings - Ieee Ultrasonics Symposium, 2008, p. 962-965en_US
dc.identifier.issn1051-0117en_US
dc.identifier.urihttp://hdl.handle.net/10722/167111-
dc.description.abstractThe objective of this study is to validate twodimensional (2D) myocardial elastography estimates in canine hearts in vivo against direct sonomicrometry measurements at variable levels of myocardial ischemia induced by the occlusion of the left anterior descending (LAD) coronary artery. Twodimensional myocardial elastography comprised transmural: 1) 2D (lateral and axial) displacements using 1D cross-correlation in a 2D search and recorrelation (3.5 mm window size; 80% overlap); 2) 2D Lagrangian strain estimation using a leastsquared strain estimator; and 3) polar (radial and circumferential) strains through coordinate transformation. An Ultrasonix RP system with a 3.3 MHz phased array and 128 beams was used to acquire RF frames in a 2D short-axis view at the frame rate of 211 fps using an automatic composite technique previously developed by our group. A non-survival canine ischemic model was performed by inducing an occlusion of the LAD coronary artery, from 0% to 100% at a 20% increment. Two separate sets of four piezoelectric crystals (1 in the subepicardium; 1 in the sub-endocardium; 2 at the epicardium) in a tetrahedral configuration were placed in the ischemic (i.e., anterior) and normal (i.e., posterior) regions. Polar strains were calculated from the coordinates of the crystals. Reduced radial thickening or radial thinning at the occlusion level larger than 40% were observed based on strain estimates from both 2D myocardial elastography and sonomicrometry. Good agreement in radial strain between the two methods was found from the Bland-Altman analysis. These findings demonstrate that 2D myocardial elastography could serve as a powerful diagnostic tool to non-invasively detect, localize and identify the ischemic region at its very early stages, i.e., at 40% coronary artery occlusion. © 2008 IEEE.en_US
dc.languageengen_US
dc.relation.ispartofProceedings - IEEE Ultrasonics Symposiumen_US
dc.subjectAngle-Independenten_US
dc.subjectCircumferentialen_US
dc.subjectCross-Correlationen_US
dc.subjectElastographyen_US
dc.subjectIschemiaen_US
dc.subjectMyocardialen_US
dc.subjectOcclusionen_US
dc.subjectRadialen_US
dc.subjectRadiofrequencyen_US
dc.subjectRecorrelationen_US
dc.subjectStrainen_US
dc.titleIn vivo validation of 2D myocardial elastography at variable levels of ischemiaen_US
dc.typeConference_Paperen_US
dc.identifier.emailLee, WN: wnlee@hku.hken_US
dc.identifier.authorityLee, WN=rp01663en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1109/ULTSYM.2008.0232en_US
dc.identifier.scopuseid_2-s2.0-67649337303en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-67649337303&selection=ref&src=s&origin=recordpageen_US
dc.identifier.spage962en_US
dc.identifier.epage965en_US
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridLee, WN=22634980600en_US
dc.identifier.scopusauthoridProvost, J=7103236841en_US
dc.identifier.scopusauthoridWang, S=7410338987en_US
dc.identifier.scopusauthoridFujikura, K=7004375160en_US
dc.identifier.scopusauthoridWang, J=8061150000en_US
dc.identifier.scopusauthoridKonofagou, EE=7005877325en_US

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