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Conference Paper: Angle-independent myocardial elastography - Theoretical analysis and clinical validation

TitleAngle-independent myocardial elastography - Theoretical analysis and clinical validation
Authors
KeywordsAngle-Independent
Echocardiography
Elastography
Ischemia
Left Ventricle
Myocardial
Strain
Issue Date2007
PublisherS P I E - International Society for Optical Engineering. The Journal's web site is located at http://www.spie.org/app/Publications/index.cfm?fuseaction=proceedings
Citation
Progress In Biomedical Optics And Imaging - Proceedings Of Spie, 2007, v. 6513 How to Cite?
AbstractSeveral methods have been introduced in the past few years to quantify left-ventricular strain in order to detect myocardial ischemia and infarction. Myocardial Elastography is one of these methods, which is based on ultrasound Radio-Frequency (RF) signal processing at high frame rates for the highest precision and resolution of strain estimation. Myocardial elastography estimates displacement and strain during the natural contraction of the myocardium using cross-correlation techniques. We have previously shown that imaging of the myocardial strain at high precision allows the correct assessment of the contractility of the cardiac muscle and thus measurement of the extent of ischemia or infarct. In this paper, for the first time in echocardiography, we show how angle-independent techniques can be used to estimate and image the mechanics of normal and pathological myocardia, both in simulations and in vivo. First, the fundamental limits of 2D normal and principal strain component estimation are determined using an ultrasound image formation model and a 2D short-axis view of a 3D left-ventricular, finite-element model, in normal and ischemic configurations. Two-dimensional (i.e., lateral and axial) cumulative displacement and strain components were iteratively estimated and imaged using ID cross-correlation and recorrelation techniques in a 2D search. Validation of these elastographic findings in one normal human subject was performed. Principal strains were also imaged for the characterization of normal myocardium. In conclusion, the feasibility of angle-independent, 2D myocardial elastography technique was shown through the calculation of the in-plane principal strains, which was proven essential in the reliable depiction of strains independent of the beam-tissue angle or the type of sonographic view used.
Persistent Identifierhttp://hdl.handle.net/10722/167103
ISSN
References

 

DC FieldValueLanguage
dc.contributor.authorKonofagou, EEen_US
dc.contributor.authorLee, WNen_US
dc.contributor.authorFungKeeFung, SDen_US
dc.date.accessioned2012-09-28T04:04:11Z-
dc.date.available2012-09-28T04:04:11Z-
dc.date.issued2007en_US
dc.identifier.citationProgress In Biomedical Optics And Imaging - Proceedings Of Spie, 2007, v. 6513en_US
dc.identifier.issn1605-7422en_US
dc.identifier.urihttp://hdl.handle.net/10722/167103-
dc.description.abstractSeveral methods have been introduced in the past few years to quantify left-ventricular strain in order to detect myocardial ischemia and infarction. Myocardial Elastography is one of these methods, which is based on ultrasound Radio-Frequency (RF) signal processing at high frame rates for the highest precision and resolution of strain estimation. Myocardial elastography estimates displacement and strain during the natural contraction of the myocardium using cross-correlation techniques. We have previously shown that imaging of the myocardial strain at high precision allows the correct assessment of the contractility of the cardiac muscle and thus measurement of the extent of ischemia or infarct. In this paper, for the first time in echocardiography, we show how angle-independent techniques can be used to estimate and image the mechanics of normal and pathological myocardia, both in simulations and in vivo. First, the fundamental limits of 2D normal and principal strain component estimation are determined using an ultrasound image formation model and a 2D short-axis view of a 3D left-ventricular, finite-element model, in normal and ischemic configurations. Two-dimensional (i.e., lateral and axial) cumulative displacement and strain components were iteratively estimated and imaged using ID cross-correlation and recorrelation techniques in a 2D search. Validation of these elastographic findings in one normal human subject was performed. Principal strains were also imaged for the characterization of normal myocardium. In conclusion, the feasibility of angle-independent, 2D myocardial elastography technique was shown through the calculation of the in-plane principal strains, which was proven essential in the reliable depiction of strains independent of the beam-tissue angle or the type of sonographic view used.en_US
dc.languageengen_US
dc.publisherS P I E - International Society for Optical Engineering. The Journal's web site is located at http://www.spie.org/app/Publications/index.cfm?fuseaction=proceedingsen_US
dc.relation.ispartofProgress in Biomedical Optics and Imaging - Proceedings of SPIEen_US
dc.subjectAngle-Independenten_US
dc.subjectEchocardiographyen_US
dc.subjectElastographyen_US
dc.subjectIschemiaen_US
dc.subjectLeft Ventricleen_US
dc.subjectMyocardialen_US
dc.subjectStrainen_US
dc.titleAngle-independent myocardial elastography - Theoretical analysis and clinical validationen_US
dc.typeConference_Paperen_US
dc.identifier.emailLee, WN: wnlee@hku.hken_US
dc.identifier.authorityLee, WN=rp01663en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1117/12.710110en_US
dc.identifier.scopuseid_2-s2.0-35148876622en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-35148876622&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume6513en_US
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridKonofagou, EE=7005877325en_US
dc.identifier.scopusauthoridLee, WN=22634980600en_US
dc.identifier.scopusauthoridFungkeeFung, SD=14919178600en_US

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