File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Neuropeptide Y potentiates beta-adrenergic stimulation of lipolysis in 3T3-L1 adipocytes

TitleNeuropeptide Y potentiates beta-adrenergic stimulation of lipolysis in 3T3-L1 adipocytes
Authors
KeywordsAdipocyte
Beta-Adrenergic Receptor Signaling
Lipogenesis
Lipolysis
Npy
Issue Date2012
PublisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/regpep
Citation
Regulatory Peptides, 2012, v. 178 n. 1-3, p. 16-20 How to Cite?
AbstractRecently, we have shown that neuropeptide Y (NPY) is produced and upregulated in visceral adipose tissue of an early-life programmed rat model of central obesity. Moreover, we have demonstrated that NPY promotes proliferation of adipocyte precursor cells and contributes to the pathogenesis of obesity. However, the role of NPY in regulating adipocyte metabolism is poorly understood. The present study was designed to examine the effects of NPY on adipocyte metabolic function using 3T3-L1 adipocytes as an in vitro cell model system. We found that although it did not affect basal lipolysis, NPY potentiated isoproterenol (a β-adrenergic receptor agonist) stimulated lipolysis. Furthermore, this potentiation occurred upstream of adenylyl cyclase, since NPY did not enhance forskolin (an activator of adenylyl cyclase) stimulated lipolysis. In addition, NPY also augmented isoproterenol-stimulated phosphorylation of hormone sensitive lipase. In contrast, NPY did not alter the expression of several key lipolytic and lipogenic enzymes/proteins. Taken together, our results revealed a novel cross talk between the NPY and β-adrenergic signaling pathways in regulating lipolysis. Thus, the present findings add a new dimension to the dynamic role NPY plays in regulating energy balance. © 2012 Elsevier B.V.
Persistent Identifierhttp://hdl.handle.net/10722/167097
ISSN
2015 Impact Factor: 1.813
2015 SCImago Journal Rankings: 0.915
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorLi, Ren_US
dc.contributor.authorGuan, Hen_US
dc.contributor.authorYang, Ken_US
dc.date.accessioned2012-09-28T04:03:40Z-
dc.date.available2012-09-28T04:03:40Z-
dc.date.issued2012en_US
dc.identifier.citationRegulatory Peptides, 2012, v. 178 n. 1-3, p. 16-20en_US
dc.identifier.issn0167-0115en_US
dc.identifier.urihttp://hdl.handle.net/10722/167097-
dc.description.abstractRecently, we have shown that neuropeptide Y (NPY) is produced and upregulated in visceral adipose tissue of an early-life programmed rat model of central obesity. Moreover, we have demonstrated that NPY promotes proliferation of adipocyte precursor cells and contributes to the pathogenesis of obesity. However, the role of NPY in regulating adipocyte metabolism is poorly understood. The present study was designed to examine the effects of NPY on adipocyte metabolic function using 3T3-L1 adipocytes as an in vitro cell model system. We found that although it did not affect basal lipolysis, NPY potentiated isoproterenol (a β-adrenergic receptor agonist) stimulated lipolysis. Furthermore, this potentiation occurred upstream of adenylyl cyclase, since NPY did not enhance forskolin (an activator of adenylyl cyclase) stimulated lipolysis. In addition, NPY also augmented isoproterenol-stimulated phosphorylation of hormone sensitive lipase. In contrast, NPY did not alter the expression of several key lipolytic and lipogenic enzymes/proteins. Taken together, our results revealed a novel cross talk between the NPY and β-adrenergic signaling pathways in regulating lipolysis. Thus, the present findings add a new dimension to the dynamic role NPY plays in regulating energy balance. © 2012 Elsevier B.V.en_US
dc.languageengen_US
dc.publisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/regpepen_US
dc.relation.ispartofRegulatory Peptidesen_US
dc.subjectAdipocyteen_US
dc.subjectBeta-Adrenergic Receptor Signalingen_US
dc.subjectLipogenesisen_US
dc.subjectLipolysisen_US
dc.subjectNpyen_US
dc.titleNeuropeptide Y potentiates beta-adrenergic stimulation of lipolysis in 3T3-L1 adipocytesen_US
dc.typeArticleen_US
dc.identifier.emailLi, R: raymondli@hku.hken_US
dc.identifier.authorityLi, R=rp01649en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/j.regpep.2012.06.002en_US
dc.identifier.pmid22750277-
dc.identifier.scopuseid_2-s2.0-84865354342en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-84865354342&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume178en_US
dc.identifier.issue1-3en_US
dc.identifier.spage16en_US
dc.identifier.epage20en_US
dc.identifier.isiWOS:000309379800004-
dc.publisher.placeNetherlandsen_US
dc.identifier.scopusauthoridLi, R=7404724295en_US
dc.identifier.scopusauthoridGuan, H=55314121600en_US
dc.identifier.scopusauthoridYang, K=7404292099en_US
dc.identifier.citeulike11810848-

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats