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- Publisher Website: 10.1016/j.metabol.2011.03.002
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- PMID: 21550088
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Article: Vitamin D deficiency is common and associated with metabolic risk factors in patients with polycystic ovary syndrome
Title | Vitamin D deficiency is common and associated with metabolic risk factors in patients with polycystic ovary syndrome |
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Authors | |
Issue Date | 2011 |
Publisher | WB Saunders Co. The Journal's web site is located at http://www.elsevier.com/locate/metabol |
Citation | Metabolism: Clinical And Experimental, 2011, v. 60 n. 10, p. 1475-1481 How to Cite? |
Abstract | Both vitamin D deficiency and polycystic ovary syndrome (PCOS) are associated with aspects of metabolic syndrome, but it is unclear whether vitamin D deficiency contributes to the metabolic disturbances commonly found in women with PCOS. This study sought to investigate (1) the prevalence of vitamin D deficiency in PCOS women in Scotland and (2) the relationship between vitamin D status and metabolic risk factors. This was an observational study on 52 women (25 in PCOS group and 27 in control group). Serum 25-hydroxyvitamin D concentrations less than 25 nmol/L were classified as severe vitamin D deficiency and were found in 44.0% and 11.2% of subjects in the PCOS and control groups, respectively (P =.047). Among the PCOS subjects, 25-hydroxyvitamin D concentrations were negatively correlated with body mass index (P =.033), C-reactive protein (P =.027), and free androgen index (P =.025) and positively correlated with quantitative insulin sensitivity check index (P =.035), high-density lipoprotein cholesterol (HDL-C) (P =.033), and sex hormone binding globulin (P =.038). Associations of vitamin D deficiency with quantitative insulin sensitivity check index and HDL-C were independent of body mass index and waist-to-hip ratio. Vitamin D deficiency is highly prevalent in PCOS women in Scotland, and a larger proportion of PCOS patients than control women were found to be vitamin D deficient. We also demonstrate correlations of vitamin D status with insulin sensitivity, HDL-C, and C-reactive protein in PCOS patients, which support the increasing evidence that vitamin D deficiency is associated with multiple metabolic risk factors in PCOS women. © 2011 Elsevier Inc. |
Persistent Identifier | http://hdl.handle.net/10722/167094 |
ISSN | 2023 Impact Factor: 10.8 2023 SCImago Journal Rankings: 2.792 |
ISI Accession Number ID | |
References |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Li, HWR | en_US |
dc.contributor.author | Brereton, RE | en_US |
dc.contributor.author | Anderson, RA | en_US |
dc.contributor.author | Wallace, AM | en_US |
dc.contributor.author | Ho, CKM | en_US |
dc.date.accessioned | 2012-09-28T04:03:39Z | - |
dc.date.available | 2012-09-28T04:03:39Z | - |
dc.date.issued | 2011 | en_US |
dc.identifier.citation | Metabolism: Clinical And Experimental, 2011, v. 60 n. 10, p. 1475-1481 | en_US |
dc.identifier.issn | 0026-0495 | en_US |
dc.identifier.uri | http://hdl.handle.net/10722/167094 | - |
dc.description.abstract | Both vitamin D deficiency and polycystic ovary syndrome (PCOS) are associated with aspects of metabolic syndrome, but it is unclear whether vitamin D deficiency contributes to the metabolic disturbances commonly found in women with PCOS. This study sought to investigate (1) the prevalence of vitamin D deficiency in PCOS women in Scotland and (2) the relationship between vitamin D status and metabolic risk factors. This was an observational study on 52 women (25 in PCOS group and 27 in control group). Serum 25-hydroxyvitamin D concentrations less than 25 nmol/L were classified as severe vitamin D deficiency and were found in 44.0% and 11.2% of subjects in the PCOS and control groups, respectively (P =.047). Among the PCOS subjects, 25-hydroxyvitamin D concentrations were negatively correlated with body mass index (P =.033), C-reactive protein (P =.027), and free androgen index (P =.025) and positively correlated with quantitative insulin sensitivity check index (P =.035), high-density lipoprotein cholesterol (HDL-C) (P =.033), and sex hormone binding globulin (P =.038). Associations of vitamin D deficiency with quantitative insulin sensitivity check index and HDL-C were independent of body mass index and waist-to-hip ratio. Vitamin D deficiency is highly prevalent in PCOS women in Scotland, and a larger proportion of PCOS patients than control women were found to be vitamin D deficient. We also demonstrate correlations of vitamin D status with insulin sensitivity, HDL-C, and C-reactive protein in PCOS patients, which support the increasing evidence that vitamin D deficiency is associated with multiple metabolic risk factors in PCOS women. © 2011 Elsevier Inc. | en_US |
dc.language | eng | en_US |
dc.publisher | WB Saunders Co. The Journal's web site is located at http://www.elsevier.com/locate/metabol | en_US |
dc.relation.ispartof | Metabolism: Clinical and Experimental | en_US |
dc.subject.mesh | Adolescent | en_US |
dc.subject.mesh | Adult | en_US |
dc.subject.mesh | Case-Control Studies | en_US |
dc.subject.mesh | Female | en_US |
dc.subject.mesh | Humans | en_US |
dc.subject.mesh | Hyperandrogenism - Blood - Complications - Epidemiology | en_US |
dc.subject.mesh | Metabolic Syndrome X - Blood - Epidemiology - Etiology | en_US |
dc.subject.mesh | Obesity - Blood - Complications - Epidemiology | en_US |
dc.subject.mesh | Pilot Projects | en_US |
dc.subject.mesh | Polycystic Ovary Syndrome - Blood - Complications - Epidemiology | en_US |
dc.subject.mesh | Prevalence | en_US |
dc.subject.mesh | Risk Factors | en_US |
dc.subject.mesh | Scotland - Epidemiology | en_US |
dc.subject.mesh | Vitamin D - Analogs & Derivatives - Blood | en_US |
dc.subject.mesh | Vitamin D Deficiency - Blood - Complications - Epidemiology | en_US |
dc.subject.mesh | Young Adult | en_US |
dc.title | Vitamin D deficiency is common and associated with metabolic risk factors in patients with polycystic ovary syndrome | en_US |
dc.type | Article | en_US |
dc.identifier.email | Li, HWR: raymondli@hku.hk | en_US |
dc.identifier.authority | Li, HWR=rp01649 | en_US |
dc.description.nature | link_to_subscribed_fulltext | en_US |
dc.identifier.doi | 10.1016/j.metabol.2011.03.002 | en_US |
dc.identifier.pmid | 21550088 | - |
dc.identifier.scopus | eid_2-s2.0-80052969896 | en_US |
dc.identifier.hkuros | 222178 | - |
dc.relation.references | http://www.scopus.com/mlt/select.url?eid=2-s2.0-80052969896&selection=ref&src=s&origin=recordpage | en_US |
dc.identifier.volume | 60 | en_US |
dc.identifier.issue | 10 | en_US |
dc.identifier.spage | 1475 | en_US |
dc.identifier.epage | 1481 | en_US |
dc.identifier.isi | WOS:000295347900017 | - |
dc.publisher.place | United States | en_US |
dc.identifier.scopusauthorid | Li, HWR=8554164300 | en_US |
dc.identifier.scopusauthorid | Brereton, RE=53163299800 | en_US |
dc.identifier.scopusauthorid | Anderson, RA=35408622600 | en_US |
dc.identifier.scopusauthorid | Wallace, AM=7201513465 | en_US |
dc.identifier.scopusauthorid | Ho, CKM=7404652809 | en_US |
dc.identifier.citeulike | 9302292 | - |
dc.identifier.issnl | 0026-0495 | - |