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Article: Indices of language outcome 11 years after intrathecal chemotherapy for acute lymphoblastic leukemia: A sibling case-control study

TitleIndices of language outcome 11 years after intrathecal chemotherapy for acute lymphoblastic leukemia: A sibling case-control study
Authors
KeywordsAll
Late Effects
Neuro-Oncology
Quality Of Life/Psychosocial
Issue Date2012
PublisherInforma Healthcare. The Journal's web site is located at http://www.tandf.co.uk/journals/titles/08880018.asp
Citation
Pediatric Hematology And Oncology, 2012, v. 29 n. 2, p. 176-190 How to Cite?
AbstractStudies are emerging that suggest that major language indices do not differentiate children treated for acute lymphoblastic leukemia (ALL) with risk-adapted intrathecal chemotherapy (ITC) from control children matched on age, gender, and educational level. No study to date has controlled for cognitive environment, an important variable influencing language achievement and outcome. This case-control study applies the deconfounding principle by using a sibling as a control to investigate language outcomes in a male child 11 years after administration of ITC for ALL at the age of 2 years 3 months. A comprehensive behavioral language test battery failed to differentiate the siblings on current language performance when descriptively compared, but neurophysiological assessment revealed that the ITC-treated child required more time and elicited a smaller N400 component compared to his sibling during picture-word matching. The findings suggest that in the absence of pretreatment performance indices, comparison with sibling achievement may supplement what is known on posttreatment language skill development drawn from comparative studies using children matched on age, sex, and educational level drawn from the community. The study's findings offer pilot data of language outcomes following ITC beyond the early stage of survivorship. The benefits and limitations of using siblings in research where the cognitive environment is known to make an important contribution to skill development are discussed. © 2012 Informa Healthcare USA, Inc.
Persistent Identifierhttp://hdl.handle.net/10722/167084
ISSN
2015 Impact Factor: 1.09
2015 SCImago Journal Rankings: 0.473
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorLewis, FMen_US
dc.contributor.authorSu, IFen_US
dc.contributor.authorMurdoch, BEen_US
dc.date.accessioned2012-09-28T04:03:11Z-
dc.date.available2012-09-28T04:03:11Z-
dc.date.issued2012en_US
dc.identifier.citationPediatric Hematology And Oncology, 2012, v. 29 n. 2, p. 176-190en_US
dc.identifier.issn0888-0018en_US
dc.identifier.urihttp://hdl.handle.net/10722/167084-
dc.description.abstractStudies are emerging that suggest that major language indices do not differentiate children treated for acute lymphoblastic leukemia (ALL) with risk-adapted intrathecal chemotherapy (ITC) from control children matched on age, gender, and educational level. No study to date has controlled for cognitive environment, an important variable influencing language achievement and outcome. This case-control study applies the deconfounding principle by using a sibling as a control to investigate language outcomes in a male child 11 years after administration of ITC for ALL at the age of 2 years 3 months. A comprehensive behavioral language test battery failed to differentiate the siblings on current language performance when descriptively compared, but neurophysiological assessment revealed that the ITC-treated child required more time and elicited a smaller N400 component compared to his sibling during picture-word matching. The findings suggest that in the absence of pretreatment performance indices, comparison with sibling achievement may supplement what is known on posttreatment language skill development drawn from comparative studies using children matched on age, sex, and educational level drawn from the community. The study's findings offer pilot data of language outcomes following ITC beyond the early stage of survivorship. The benefits and limitations of using siblings in research where the cognitive environment is known to make an important contribution to skill development are discussed. © 2012 Informa Healthcare USA, Inc.en_US
dc.languageengen_US
dc.publisherInforma Healthcare. The Journal's web site is located at http://www.tandf.co.uk/journals/titles/08880018.aspen_US
dc.relation.ispartofPediatric Hematology and Oncologyen_US
dc.subjectAllen_US
dc.subjectLate Effectsen_US
dc.subjectNeuro-Oncologyen_US
dc.subjectQuality Of Life/Psychosocialen_US
dc.titleIndices of language outcome 11 years after intrathecal chemotherapy for acute lymphoblastic leukemia: A sibling case-control studyen_US
dc.typeArticleen_US
dc.identifier.emailSu, IF: ifansu@hku.hken_US
dc.identifier.authoritySu, IF=rp01650en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.3109/08880018.2011.627417en_US
dc.identifier.pmid22303906-
dc.identifier.scopuseid_2-s2.0-84857879338en_US
dc.identifier.hkuros204440-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-84857879338&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume29en_US
dc.identifier.issue2en_US
dc.identifier.spage176en_US
dc.identifier.epage190en_US
dc.identifier.isiWOS:000300873800011-
dc.publisher.placeUnited Kingdomen_US
dc.identifier.scopusauthoridLewis, FM=7202262526en_US
dc.identifier.scopusauthoridSu, IF=55060380500en_US
dc.identifier.scopusauthoridMurdoch, BE=7005161745en_US

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