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Article: Comparison of Humalog Mix 50 with human insulin Mix 30 in type 2 diabetes patients during Ramadan

TitleComparison of Humalog Mix 50 with human insulin Mix 30 in type 2 diabetes patients during Ramadan
Authors
Issue Date2010
PublisherBlackwell Publishing Ltd. The Journal's web site is located at http://www.blackwellpublishing.com/journals/IJCP
Citation
International Journal Of Clinical Practice, 2010, v. 64 n. 8, p. 1095-1099 How to Cite?
AbstractAims: To compare hypoglycaemic events, glycated haemoglobin (HbA1c) and changes in body weight in Muslim patients with Type 2 diabetes receiving Humalog Mix 50 and human Mixtard 30 twice daily during Ramadan fasting. Methods: Data were collected from Muslim patients with Type 2 diabetes attending primary care practices in North-West London, who were on Mixtard 30 insulin twice daily before Ramadan. Group 1 had their evening insulin changed to Humalog Mix 50 (n = 26) 2 weeks before Ramadan, i.e. taking Mixtard 30 at predawn meal and Humalog Mix 50 at the sunset meal during Ramadan. As the major proportion of the daily caloric intake was consumed at the sunset meal, the rationale of switching the evening dose from human Mixtard 30 to Humalog Mix 50 was to provide more rapid-acting insulin that has shorter time of onset and peak time for the large evening meal to improve the postprandial glucose control without increasing the risk of hypoglycaemia. Group 2 continued on Mixtard 30 twice daily (n = 26). All patients received structured education about how to identify and manage hypoglycaemia during Ramadan. Results: Group 1 had a mean HbA1c reduction of 0.48% (p = 0.0001) before and after Ramadan, whereas group 2 had a mean HbA1c increase of 0.28% (p = 0.007). Group 1 was associated with a small reduction of 0.04 (p = 0.81) in the mean number of hypoglycaemic events during Ramadan compared with before Ramadan, whereas group 2 was associated with an increase of 0.15 (p = 0.43), although these differences between the groups were not statistically significant following adjustment for baseline factors [LSM difference between groups = 0.135, p = 0.36, 95% confidence limits (-0.16, 0.43)]. Conclusion: Changing to humalog Mix 50 during Ramadan resulted in improvement in glycaemic control without increasing the incidence of hypoglycaemia. © 2010 Blackwell Publishing Ltd.
Persistent Identifierhttp://hdl.handle.net/10722/167068
ISSN
2015 Impact Factor: 2.226
2015 SCImago Journal Rankings: 0.759
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorHui, Een_US
dc.contributor.authorBravis, Ven_US
dc.contributor.authorSalih, Sen_US
dc.contributor.authorHassanein, Men_US
dc.contributor.authorDevendra, Den_US
dc.date.accessioned2012-09-28T04:02:42Z-
dc.date.available2012-09-28T04:02:42Z-
dc.date.issued2010en_US
dc.identifier.citationInternational Journal Of Clinical Practice, 2010, v. 64 n. 8, p. 1095-1099en_US
dc.identifier.issn1368-5031en_US
dc.identifier.urihttp://hdl.handle.net/10722/167068-
dc.description.abstractAims: To compare hypoglycaemic events, glycated haemoglobin (HbA1c) and changes in body weight in Muslim patients with Type 2 diabetes receiving Humalog Mix 50 and human Mixtard 30 twice daily during Ramadan fasting. Methods: Data were collected from Muslim patients with Type 2 diabetes attending primary care practices in North-West London, who were on Mixtard 30 insulin twice daily before Ramadan. Group 1 had their evening insulin changed to Humalog Mix 50 (n = 26) 2 weeks before Ramadan, i.e. taking Mixtard 30 at predawn meal and Humalog Mix 50 at the sunset meal during Ramadan. As the major proportion of the daily caloric intake was consumed at the sunset meal, the rationale of switching the evening dose from human Mixtard 30 to Humalog Mix 50 was to provide more rapid-acting insulin that has shorter time of onset and peak time for the large evening meal to improve the postprandial glucose control without increasing the risk of hypoglycaemia. Group 2 continued on Mixtard 30 twice daily (n = 26). All patients received structured education about how to identify and manage hypoglycaemia during Ramadan. Results: Group 1 had a mean HbA1c reduction of 0.48% (p = 0.0001) before and after Ramadan, whereas group 2 had a mean HbA1c increase of 0.28% (p = 0.007). Group 1 was associated with a small reduction of 0.04 (p = 0.81) in the mean number of hypoglycaemic events during Ramadan compared with before Ramadan, whereas group 2 was associated with an increase of 0.15 (p = 0.43), although these differences between the groups were not statistically significant following adjustment for baseline factors [LSM difference between groups = 0.135, p = 0.36, 95% confidence limits (-0.16, 0.43)]. Conclusion: Changing to humalog Mix 50 during Ramadan resulted in improvement in glycaemic control without increasing the incidence of hypoglycaemia. © 2010 Blackwell Publishing Ltd.en_US
dc.languageengen_US
dc.publisherBlackwell Publishing Ltd. The Journal's web site is located at http://www.blackwellpublishing.com/journals/IJCPen_US
dc.relation.ispartofInternational Journal of Clinical Practiceen_US
dc.subject.meshAgeden_US
dc.subject.meshBiphasic Insulinsen_US
dc.subject.meshBody Weighten_US
dc.subject.meshDiabetes Mellitus, Type 2 - Drug Therapyen_US
dc.subject.meshDrug Administration Scheduleen_US
dc.subject.meshFasting - Blooden_US
dc.subject.meshFemaleen_US
dc.subject.meshHemoglobin A, Glycosylated - Metabolismen_US
dc.subject.meshHumansen_US
dc.subject.meshHypoglycemia - Chemically Induceden_US
dc.subject.meshHypoglycemic Agents - Administration & Dosageen_US
dc.subject.meshInsulin - Administration & Dosage - Analogs & Derivativesen_US
dc.subject.meshInsulin Lisproen_US
dc.subject.meshInsulin, Isophaneen_US
dc.subject.meshInsulin, Long-Acting - Administration & Dosageen_US
dc.subject.meshIslamen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshRisk Factorsen_US
dc.subject.meshYoung Adulten_US
dc.titleComparison of Humalog Mix 50 with human insulin Mix 30 in type 2 diabetes patients during Ramadanen_US
dc.typeArticleen_US
dc.identifier.emailHui, E: eylhui@hku.hken_US
dc.identifier.authorityHui, E=rp01660en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1111/j.1742-1241.2010.02347.xen_US
dc.identifier.pmid20337752-
dc.identifier.scopuseid_2-s2.0-77953840767en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-77953840767&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume64en_US
dc.identifier.issue8en_US
dc.identifier.spage1095en_US
dc.identifier.epage1099en_US
dc.identifier.isiWOS:000278920800020-
dc.publisher.placeUnited Kingdomen_US
dc.identifier.scopusauthoridHui, E=25651582800en_US
dc.identifier.scopusauthoridBravis, V=25651274000en_US
dc.identifier.scopusauthoridSalih, S=35263298800en_US
dc.identifier.scopusauthoridHassanein, M=7004441683en_US
dc.identifier.scopusauthoridDevendra, D=6701796681en_US
dc.identifier.citeulike7405898-

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